Search Results - "Ramage, Robert"

Determination of ten monohydroxylated polycyclic aromatic hydrocarbons by liquid–liquid extraction and liquid chromatography/tandem mass spectrometry by Fan, Ruifang, Ramage, Robert, Wang, Dongli, Zhou, Junqiang, She, Jianwen

“…► It is the first time to use liquid–liquid extraction and LC/MS/MS for OH-PAHs analysis. ► The limits of detection were lower than or comparable to those from…”
Get full text

Development of HPLC-MS/MS method for the simultaneous determination of environmental phenols in human urine by Gavin, Qi W., Ramage, Robert T., Waldman, Jed M., She, Jianwen

“…We present a sensitive method for simultaneous determination of bisphenol A (BPA), benzophenone-3 (BP-3), 4-tert-octylphenol (t-OP), ortho-phenylphenol (OPP),…”
Get full text

Essential role for proteinase-activated receptor-2 in arthritis by Ferrell, William R, Lockhart, John C, Kelso, Elizabeth B, Dunning, Lynette, Plevin, Robin, Meek, Stephen E, Smith, Andrew J H, Hunter, Gary D, McLean, John S, McGarry, Frances, Ramage, Robert, Jiang, Lu, Kanke, Toru, Kawagoe, Junichi

“…Using physiological, pharmacological, and gene disruption approaches, we demonstrate that proteinase-activated receptor-2 (PAR-2) plays a pivotal role in…”
Get full text

Essential role for proteinase-activated receptor-2 in arthritis by Ferrell, William R., Lockhart, John C., Kelso, Elizabeth B., Dunning, Lynette, Plevin, Robin, Meek, Stephen E., Smith, Andrew J.H., Hunter, Gary D., McLean, John S., McGarry, Frances, Ramage, Robert, Jiang, Lu, Kanke, Toru, Kawagoe, Junichi

“…Using physiological, pharmacological, and gene disruption approaches, we demonstrate that proteinase-activated receptor-2 (PAR-2) plays a pivotal role in…”
Get full text

Inhibition of the Ubiquitin-Proteasome System in Alzheimer's Disease by Lam, Y A, Pickart, C M, Alban, A, Landon, M, Jamieson, C, Ramage, R, Mayer, R J, Layfield, R

“…Alzheimer's disease is the most common cause of dementia in the elderly. Although several genetic defects have been identified in patients with a family…”
Get full text

Synthesis and application of a novel coupling reagent, ethyl 1-hydroxy-1H -1,2,3-triazole-4-carboxylate by Jiang, Lu, Davison, Amanda, Tennant, George, Ramage, Robert

“…An optimal coupling reagent, ethyl 1-hydroxy-1H-1,2,3-triazole-4-carboxylate (HOCt), has been designed and synthesised for application to solid phase peptide…”
Get full text

Fast and Simultaneous Determination of Urinary 8-Hydroxy-2′-deoxyguanosine and Ten Monohydroxylated Polycyclic Aromatic Hydrocarbons by Liquid Chromatography/Tandem Mass Spectrometry by Fan, Ruifang, Wang, Dongli, Ramage, Robert, She, Jianwen

“…8-Hydroxy-2′-deoxyguanosine (8-OHdG), a biomarker of oxidative DNA damage, has been extensively studied to assess human exposure to carcinogenic compounds…”
Get full text

Racemisation studies of a novel coupling reagent for solid phase peptide synthesis by Robertson, Nicola, Jiang, Lu, Ramage, Robert

“…A novel coupling reagent ethyl 1-hydroxy-1H-1,2,3-triazole-4-carboxylate has been developed for use in conjunction with diisopropylcarbodiimide for solid phase…”
Get full text

A solid phase approach to quinolones using the DIVERSOMER ® technology by MacDonald, Alasdair A, DeWitt, Sheila H, Hogan, Eleonora M, Ramage, Robert

“…The first example of a library of the quinolone antibacterial agents prepared by solid phase organic synthesis is described. Results of these studies and the…”
Get full text

Use of tetrabenzo[ a,c,g,i]fluorene as an anchor group for the solid/solution phase synthesis of Ciprofloxacin by Hay, Alastair M., Hobbs-Dewitt, Sheila, MacDonald, Alasdair A., Ramage, Robert

“…The affinity of tetrabenzo[ a,c,g,i]fluorene for charcoal has been applied successfully to provide an alternative to existing solid phase synthesis…”
Get full text

Measurements of polybrominated diphenyl ethers and polychlorinated biphenyls in a single drop of blood by Lu, Dasheng, Wang, Dongli, Ip, Ho Sai Simon, Barley, Frank, Ramage, Robert, She, Jianwen

“…► A method was developed and well validated to determine PCBs and PBDEs in a small volume (50μL) of blood samples and in dried blood spots. ► Measurements of…”
Get full text

9-Aminoacridine peptide derivatives as versatile reporter systems for use in fluorescence lifetime assays by Maltman, Beatrice A, Dunsmore, Colin J, Couturier, Sarah C M, Tirnaveanu, Adina E, Delbederi, Zoica, McMordie, R Austin S, Naredo, Gregorio, Ramage, Robert, Cotton, Graham

“…A novel long lifetime fluorescence reporter based on 9-aminoacridine was designed, the lifetime of which can be modulated in a defined manner when in proximity…”
Get more information

The Antimicrobial Antiproteinase Elafin Binds to Lipopolysaccharide and Modulates Macrophage Responses by McMichael, Jonathan W, Roghanian, Ali, Jiang, Lu, Ramage, Robert, Sallenave, Jean-Michel

“…Lipopolysaccharides (LPS) of the outer membrane of Gram-negative bacteria represent a primary target for innate immune responses. We demonstrate here that the…”
Get full text

Synthesis of a novel silicon bearing linker for solid phase synthesis by Ramage, Robert, Andrews, Martin J.I., Raphy, Jenny, Wang, Pu

“…The synthesis of a novel fluoride cleavable linker is described. A novel linker for solid phase synthesis is described, which exhibits rapid cleavage under…”
Get full text

Innate immune system damage in human immunodeficiency virus type 1 infection: Implications for acquired immunity and vaccine design by HOWIE, Sarah, RAMAGE, Robert, HEWSON, T. I. M

“…HIV infection affects the innate as well as the acquired immune systems. Critically, it changes the function of macrophages, which link the innate and acquired…”
Get full text

Solid phase synthesis of peptide C-terminal semicarbazones and aldehydes by Patterson, Jennifer A., Ramage, Robert

“…A new linker based on the dibenzosuberyl system was developed in order to synthesise peptide C-terminal semicarbazones which can be readily converted into…”
Get full text

Mapping the Active Site of Endothelin-Converting Enzyme-1 through Subsite Specificity and Mutagenesis Studies: A Comparison with Neprilysin by Johnson, Gary D., Swenson, Helen R., Ramage, Robert, Ahn, Kyunghye

“…Endothelin-converting enzyme-1 (ECE-1) is a membrane-bound zinc metallopeptidase that is homologous to neprilysin in amino acid sequence. A major in vivo…”
Get full text

Synthesis, Structural and Biological Studies of Ubiquitin Mutants Containing (2S, 4S)-5-Fluoroleucine Residues Strategically Placed in the Hydrophobic Core by Alexeev, Dmitriy, Barlow, Paul N, Bury, Stella M, Charrier, Jean-Damien, Cooper, Alan, Hadfield, David, Jamieson, Craig, Kelly, Sharon M, Layfield, Robert, Mayer, R. John, McSparron, Helen, Price, Nicholas C, Ramage, Robert, Sawyer, Lindsay, Starkmann, Bernard A, Uhrin, Dusan, Wilken, Jill, Young, Douglas W

“…Insider report: A fluoroleucine mutant of ubiquitin (cyan) with two strategically placed fluorine reporter groups in its core was synthesised. 1H NMR,…”
Get full text

Chemically Synthesized Ubiquitin Extension Proteins Detect Distinct Catalytic Capacities of Deubiquitinating Enzymes by Layfield, Robert, Franklin, Kate, Landon, Michael, Walker, Gail, Wang, Pu, Ramage, Robert, Brown, Angus, Love, Steven, Urquhart, Kirstie, Muir, Thomas, Baker, Rohan, Mayer, R.John

“…We have used solid-phase chemistry to synthesize proteins equivalent to a human ubiquitin precursor (ubiquitin–52-amino-acid ribosomal protein fusion;…”
Get full text

The effect of carbide morphology and distribution on the uniaxial deformation of iron-carbon-X alloys by Ramage, Robert Mark

“…Precipitate distribution effects on the uniaxial deformation in ferrite/martensite aggregates have been investigated in four Fe-C-X (X = Mn, Mo, V, W) alloys…”
Get full text