Search Results - "Ramaekers, F C"

Nuclear Lamins: Laminopathies and Their Role in Premature Ageing by Broers, J. L. V, Ramaekers, F. C. S, Bonne, G, Yaou, R. Ben, Hutchison, C. J

“…Department of Molecular Cell Biology, University of Maastricht, Research Institutes CARIM, GROW, and EURON, Maastricht; Department of Biomechanics and Tissue…”
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Marked differences in survival rate between smokers and nonsmokers with HPV 16‐associated tonsillar carcinomas by Hafkamp, Harriët C., Manni, J.J., Haesevoets, A., Voogd, A.C., Schepers, M., Bot, F.J., Hopman, A.H.N., Ramaekers, F.C.S., Speel, Ernst‐Jan M.

“…Oncogenic human papillomavirus (HPV) is a causative agent in a subgroup of head and neck carcinomas, particularly tonsillar squamous cell carcinomas (TSCC)…”
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Genomic integration of oncogenic HPV and gain of the human telomerase gene TERC at 3q26 are strongly associated events in the progression of uterine cervical dysplasia to invasive cancer by Hopman, AHN, Theelen, W, Hommelberg, PPH, Kamps, MAF, Herrington, CS, Morrison, LE, Speel, E-JM, Smedts, F, Ramaekers, FCS

“…Recently proposed events associated with the progression of cervical intraepithelial neoplasia (CIN) 2/3 to cervical carcinoma include integration of human…”
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The nuclear envelope, a key structure in cellular integrity and gene expression by Verstraeten, V L R M, Broers, J L V, Ramaekers, F C S, van Steensel, M A M

“…The envelope that encapsulates the cell nucleus has recently gained considerable interest, as several clinical syndromes are linked to mutations in its…”
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Cytoplasmic localization of PML particles in laminopathies by Houben, F., De Vos, W. H., Krapels, I. P. C., Coorens, M., Kierkels, G. J. J., Kamps, M. A. F., Verstraeten, V. L. R. M., Marcelis, C. L. M., van den Wijngaard, A., Ramaekers, F. C. S., Broers, J. L. V.

“…There is growing evidence that laminopathies, diseases associated with mutations in the LMNA gene, are caused by a combination of mechanical and gene…”
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Chromosome instability in resection margins predicts recurrence of oral squamous cell carcinoma by Bergshoeff, VE, Hopman, AHN, Zwijnenberg, IR, Ramaekers, FCS, Bot, FJ, Kremer, B, Manni, JJ, Speel, E. JM

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The caspase-9 derived C-terminal fragment of cytokeratin 18 modulates topoisomerase action by SCHUTTE, B, HENFLING, M. E. R, VERHEYEN, F. K. C. P, LI, G, TOLSTONOG, G. V, RAMAEKERS, F. C. S

“…During early apoptosis the 33 amino acid C-terminal cytokeratin 18 (CK18) fragment is released by caspase-9 cleavage at the 393DALD/S site. This basic peptide…”
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DNA copy number status is a powerful predictor of poor survival in endocrine pancreatic tumor patients by Jonkers, Y M H, Claessen, S M H, Perren, A, Schmitt, A M, Hofland, L J, de Herder, W, de Krijger, R R, Verhofstad, A A J, Hermus, A R, Kummer, J A, Skogseid, B, Volante, M, Voogd, A C, Ramaekers, F C S, Speel, E J M

“…The clinical behavior of endocrine pancreatic tumors (EPTs) is difficult to predict in the absence of metastases or invasion to adjacent organs. Several…”
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The garlic-derived organosulfur component ajoene decreases basal cell carcinoma tumor size by inducing apoptosis by TILLI, C. M. L. J, STAVAST-KOOY, A. J. W, VUERSTAEK, J. D. D, THISSEN, M. R. T. M, KREKELS, G. A. M, RAMAEKERS, F. C. S, NEUMANN, H. A. M

“…Although the therapeutic role of ajoene, an organosulfur compound of garlic, in cardiovascular diseases and mycology has been established, its usefulness in…”
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Role of nuclear lamina-cytoskeleton interactions in the maintenance of cellular strength by Houben, F., Ramaekers, F.C.S., Snoeckx, L.H.E.H., Broers, J.L.V.

“…The response of individual cells to cellular stress is vital for cellular functioning. A large network of physically interconnected cellular components,…”
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Investigating the race for the surface and skin integration in clinically retrieved abutments with two-photon microscopy by Kapsokalyvas, D., van Hoof, M., Wigren, S., Chimhanda, T., Kuijpers, H.J., Ramaekers, F.C.S., Stokroos, R.J., van Zandvoort, M.A.M.J.

“…[Display omitted] •Full-length, high resolution imaging of clinically retrieved abutments.•Skin integration and hemidesmosome expression on HA coated abutments…”
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Nuclear A-type lamins are differentially expressed in human lung cancer subtypes by Broers, JL, Raymond, Y, Rot, MK, Kuijpers, H, Wagenaar, SS, Ramaekers, FC

“…Nuclear A-type and B-type lamin expression was investigated in the major human lung cancer subtypes: small cell lung cancer (SCLC), squamous cell carcinomas,…”
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Ki-67 detects a nuclear matrix-associated proliferation-related antigen. I: Intracellular localization during interphase by VERHEIJEN, R, KUIJPERS, H. J. H, SCHLINGEMANN, R. O, BOEHMER, A. L. M, VAN DRIEL, R, BRAKENHOFF, G. J, RAMAEKERS, F. C. S

“…Ki-67 is a commercially available mouse monoclonal antibody, which reacts with a nuclear antigen in proliferating cells. The antibody can be used to determine…”
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Ki-67 detects a nuclear matrix-associated proliferation-related antigen. II: Localization in mitotic cells and association with chromosomes by VERHEIJEN, R, KUIJPERS, H. J. H, VAN DRIEL, R, BECK, J. L. M, VAN DIERENDONCK, J. H, BRAKENHOFF, G. J, RAMAEKERS, F. C. S

“…In interphase cells the proliferation-associated antigen recognized by monoclonal antibody Ki-67 is almost exclusively located in the nucleoli. When cells at…”
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Proteasomes act in the pre-mitochondrial signal transduction route towards roscovitine-induced apoptosis by Henfling, M E R, Ramaekers, F C S, Schutte, B

“…The role of the ubiquitin-proteasome pathway during roscovitine induced apoptosis was evaluated in the non-small cell lung carcinoma cell line MR65. To this…”
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Disturbed nuclear orientation and cellular migration in A-type lamin deficient cells by Houben, F., Willems, C.H.M.P., Declercq, I.L.J., Hochstenbach, K., Kamps, M.A., Snoeckx, L.H.E.H., Ramaekers, F.C.S., Broers, J.L.V.

“…The nuclear lamina and the cytoskeleton form an integrated structure that warrants proper mechanical functioning of cells. We have studied the correlation…”
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Basal cell-specific and hyperproliferation-related keratins in human breast cancer by Wetzels, RH, Kuijpers, HJ, Lane, EB, Leigh, IM, Troyanovsky, SM, Holland, R, van Haelst, UJ, Ramaekers, FC

“…In normal breast tissue and in noninvasive breast carcinomas, various keratin-14 antibodies were reactive predominantly with the basal/myoepithelial cell…”
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Molecular aetiology and pathogenesis of basal cell carcinoma by Tilli, C.M.L.J., Van Steensel, M.A.M., Krekels, G.A.M., Neumann, H.A.M., Ramaekers, F.C.S.

“…Summary Recent insights into the cell biology of the epidermis and its appendages are transforming our understanding of the pathogenesis of basal cell…”
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Immunocytochemical detection and mapping of a cytokeratin 18 neo-epitope exposed during early apoptosis by Leers, Mathie P. G., Kölgen, Wendy, Björklund, Viveka, Bergman, Tomas, Tribbick, Gordon, Persson, Bengt, Björklund, Peter, Ramaekers, Frans C. S., Björklund, Bertil, Nap, Marius, Jörnvall, Hans, Schutte, Bert

“…A neo‐epitope in cytokeratin 18 (CK18) that becomes available at an early caspase cleavage event during apoptosis and is not detectable in vital epithelial…”
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Human papillomavirus typing by single tube multiplex amplification in real time (SMART): The PapillomaFinder® SMART 20 assay by Ossel, J, Litjens, R.J, Reijans, M, Brink, A.A.T.P, Ummelen, M, Ramaekers, F.C, Hopman, A.H.N, Simons, G

“…Highlights • A single-tube multiplex PCR-based HPV detection and typing assay is presented. • The assay can be performed on standard real-time PCR platforms. •…”
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