Search Results - "Ramadan, Nadire"

Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers by Hoffman, Gregory R., Rahal, Rami, Buxton, Frank, Xiang, Kay, McAllister, Gregory, Frias, Elizabeth, Bagdasarian, Linda, Huber, Janina, Lindeman, Alicia, Chen, Dongshu, Romero, Rodrigo, Ramadan, Nadire, Phadke, Tanushree, Haas, Kristy, Jaskelioff, Mariela, Wilson, Boris G., Meyer, Matthew J., Saenz-Vash, Veronica, Zhai, Huili, Myer, Vic E., Porter, Jeffrey A., Keen, Nicholas, McLaughlin, Margaret E., Mickanin, Craig, Roberts, Charles W. M., Stegmeier, Frank, Jagani, Zainab

“…Defects in epigenetic regulation play a fundamental role in the development of cancer, and epigenetic regulators have recently emerged as promising therapeutic…”
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ERG signaling in prostate cancer is driven through PRMT5-dependent methylation of the Androgen Receptor by Mounir, Zineb, Korn, Joshua M, Westerling, Thomas, Lin, Fallon, Kirby, Christina A, Schirle, Markus, McAllister, Gregg, Hoffman, Greg, Ramadan, Nadire, Hartung, Anke, Feng, Yan, Kipp, David Randal, Quinn, Christopher, Fodor, Michelle, Baird, Jason, Schoumacher, Marie, Meyer, Ronald, Deeds, James, Buchwalter, Gilles, Stams, Travis, Keen, Nicholas, Sellers, William R, Brown, Myles, Pagliarini, Raymond A

“…The TMPRSS2:ERG gene fusion is common in androgen receptor (AR) positive prostate cancers, yet its function remains poorly understood. From a screen for…”
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Design and implementation of high-throughput RNAi screens in cultured Drosophila cells by Mathey-Prevot, Bernard, Ramadan, Nadire, Flockhart, Ian, Booker, Matthew, Perrimon, Norbert

“…This protocol describes the various steps and considerations involved in planning and carrying out RNA interference (RNAi) genome-wide screens in cultured…”
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Identification of a novel NAMPT inhibitor by CRISPR/Cas9 chemogenomic profiling in mammalian cells by Estoppey, David, Hewett, Jeffrey W., Guy, Chantale T., Harrington, Edmund, Thomas, Jason R., Schirle, Markus, Cuttat, Rachel, Waldt, Annick, Gerrits, Bertran, Yang, Zinger, Schuierer, Sven, Pan, Xuewen, Xie, Kevin, Carbone, Walter, Knehr, Judith, Lindeman, Alicia, Russ, Carsten, Frias, Elizabeth, Hoffman, Gregory R., Varadarajan, Malini, Ramadan, Nadire, Reece-Hoyes, John S., Wang, Qiong, Chen, Xin, McAllister, Gregory, Roma, Guglielmo, Bouwmeester, Tewis, Hoepfner, Dominic

“…Chemogenomic profiling is a powerful and unbiased approach to elucidate pharmacological targets and the mechanism of bioactive compounds. Until recently,…”
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TRPS1 Is a Lineage-Specific Transcriptional Dependency in Breast Cancer by Witwicki, Robert M, Ekram, Muhammad B, Qiu, Xintao, Janiszewska, Michalina, Shu, Shaokun, Kwon, Mijung, Trinh, Anne, Frias, Elizabeth, Ramadan, Nadire, Hoffman, Greg, Yu, Kristine, Xie, Yingtian, McAllister, Gregory, McDonald, Rob, Golji, Javad, Schlabach, Michael, deWeck, Antoine, Keen, Nicholas, Chan, Ho Man, Ruddy, David, Rejtar, Tomas, Sovath, Sosathya, Silver, Serena, Sellers, William R, Jagani, Zainab, Hogarty, Michael D, Roberts, Charles, Brown, Myles, Stegmaier, Kimberly, Long, Henry, Shivdasani, Ramesh A, Pellman, David, Polyak, Kornelia

“…Perturbed epigenomic programs play key roles in tumorigenesis, and chromatin modulators are candidate therapeutic targets in various human cancer types. To…”
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FlyRNAi: the Drosophila RNAi screening center database by Flockhart, Ian, Booker, Matthew, Kiger, Amy, Boutros, Michael, Armknecht, Susan, Ramadan, Nadire, Richardson, Kris, Xu, Andrew, Perrimon, Norbert, Mathey-Prevot, Bernard

“…RNA interference (RNAi) has become a powerful tool for genetic screening in DROSOPHILA: At the Drosophila RNAi Screening Center (DRSC), we are using a library…”
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Abstract PR06: A functional screen of the epigenome identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers by Jagani, Zainab, Hoffman, Gregory, Rahal, Rami, Buxton, Frank, McAllister, Gregory, Xiang, Kay, Frias, Elizabeth, Huber, Janina, Lindeman, Alicia, Chen, Dongshu, Bagdasarian, Linda, Romero, Rodrigo, Ramadan, Nadire, Phadke, Tanushree, Haas, Kristy, Jaskelioff, Mariela, Wilson, Boris, Meyer, Matthew, McLaughlin, Margaret E., Roberts, Charles WM, Myer, Vic, Porter, Jeff, Keen, Nicholas, Mickanin, Craig, Stegmeier, Frank

“…Abstract Epigenetic dysregulation is an emerging hallmark of cancers, and the identification of recurrent somatic mutations in chromatin regulators implies a…”
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