Search Results - "Ramachandran, Anassuya"

TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition by Ramachandran, Anassuya, Vizán, Pedro, Das, Debipriya, Chakravarty, Probir, Vogt, Janis, Rogers, Katherine W, Müller, Patrick, Hinck, Andrew P, Sapkota, Gopal P, Hill, Caroline S

“…The best characterized signaling pathway downstream of transforming growth factor β (TGF-β) is through SMAD2 and SMAD3. However, TGF-β also induces…”
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Mesenchymal Cancer Cell-Stroma Crosstalk Promotes Niche Activation, Epithelial Reversion, and Metastatic Colonization by del Pozo Martin, Yaiza, Park, Danielle, Ramachandran, Anassuya, Ombrato, Luigi, Calvo, Fernando, Chakravarty, Probir, Spencer-Dene, Bradley, Derzsi, Stefanie, Hill, Caroline S., Sahai, Erik, Malanchi, Ilaria

“…During metastatic colonization, tumor cells must establish a favorable microenvironment or niche that will sustain their growth. However, both the temporal and…”
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MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU by Favaro, Elena, Ramachandran, Anassuya, McCormick, Robert, Gee, Harriet, Blancher, Christine, Crosby, Meredith, Devlin, Cecilia, Blick, Christopher, Buffa, Francesca, Li, Ji-Liang, Vojnovic, Borivoj, Pires das Neves, Ricardo, Glazer, Peter, Iborra, Francisco, Ivan, Mircea, Ragoussis, Jiannis, Harris, Adrian L

“…Hypoxia in cancers results in the upregulation of hypoxia inducible factor 1 (HIF-1) and a microRNA, hsa-miR-210 (miR-210) which is associated with a poor…”
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Transforming Growth Factor β Inhibits Bone Morphogenetic Protein-Induced Transcription through Novel Phosphorylated Smad1/5-Smad3 Complexes by Grönroos, Eva, Kingston, Isabel J., Ramachandran, Anassuya, Randall, Rebecca A., Vizán, Pedro, Hill, Caroline S.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Activin is a potent growth suppressor of epithelial ovarian cancer cells by Ramachandran, Anassuya, Marshall, Elaine S, Love, Donald R, Baguley, Bruce C, Shelling, Andrew N

“…Abstract Although activin is a major cytokine produced by the ovary, its role in epithelial ovarian cancer is poorly defined. Here, we demonstrate a novel role…”
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Clinically Relevant Biology of Hyaluronic Acid in the Desmoplastic Stroma of Pancreatic Ductal Adenocarcinoma by Jahedi, Hossein, Ramachandran, Anassuya, Windsor, John, Knowlton, Nicholas, Blenkiron, Cherie, Print, Cristin G.

“…Pancreatic ductal adenocarcinoma (PDAC) is notorious for its poor outcome. The presence of a dense desmoplastic stroma is a hallmark of this malignancy, and…”
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Mechanistic Insights into Deregulated TGF‐β Family Signalling in Human Disease by Hill, Caroline S., Gori, Ilaria, Kjaer, Svend, George, Roger, Ramachandran, Anassuya, Mehic, Merima, Tolar, Pavel, Hyvonen, Marko, Jones, Chris

“…Deregulation of TGF‐β family signalling underlies some serious human diseases, including cancer, the Marfan syndromes, and other connective tissue disorders…”
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Pathogenic ACVR1 R206H activation by Activin A-induced receptor clustering and autophosphorylation by Ramachandran, Anassuya, Mehić, Merima, Wasim, Laabiah, Malinova, Dessislava, Gori, Ilaria, Blaszczyk, Beata K, Carvalho, Diana M, Shore, Eileen M, Jones, Chris, Hyvönen, Marko, Tolar, Pavel, Hill, Caroline S

“…Fibrodysplasia ossificans progressiva (FOP) and diffuse intrinsic pontine glioma (DIPG) are debilitating diseases that share causal mutations in ACVR1, a TGF-β…”
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Pathogenic ACVR1R206H activation by Activin A‐induced receptor clustering and autophosphorylation by Ramachandran, Anassuya, Mehić, Merima, Wasim, Laabiah, Malinova, Dessislava, Gori, Ilaria, Blaszczyk, Beata K, Carvalho, Diana M, Shore, Eileen M, Jones, Chris, Hyvönen, Marko, Tolar, Pavel, Hill, Caroline S

“…Fibrodysplasia ossificans progressiva (FOP) and diffuse intrinsic pontine glioma (DIPG) are debilitating diseases that share causal mutations in ACVR1, a TGF‐β…”
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Alternative splicing generates isoform diversity in MEN1 by Ramachandran, Anassuya, Stabej, Polona Le Quesne, Boyle, Veronica, Elston, Marianne Susan, Pattison, Sharon, Lawrence, Ben, Print, Cris

“…Although the gene MEN1 has a long association with cancer, its mechanisms of action remain incompletely understood, being both a tumour suppressor in…”
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TGF-[beta] uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition by Ramachandran, Anassuya, Vizán, Pedro, Das, Debipriya, Chakravarty, Probir, Vogt, Janis, Rogers, Katherine W, Müller, Patrick, Hinck, Andrew P, Sapkota, Gopal P, Hill, Caroline S

“…The best characterized signaling pathway downstream of transforming growth factor [beta] (TGF-[beta]) is through SMAD2 and SMAD3. However, TGF-[beta] also…”
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Prospective technical validation and assessment of intra-tumour heterogeneity of a low density array hypoxia gene profile in head and neck squamous cell carcinoma by Betts, Guy N.J, Eustace, Amanda, Patiar, Shalini, Valentine, Helen R, Irlam, Joely, Ramachandran, Anassuya, Merve, Ashirwad, Homer, Jarrod J, Möller-Levet, Carla, Buffa, Francesca M, Hall, Gillian, Miller, Crispin J, Harris, Adrian L, West, Catharine M.L

“…Abstract Background and purpose Tumour hypoxia is associated with a poor prognosis in head and neck squamous cell carcinoma (HNSCC), however there is no…”
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Abstract 3942: The role of vHL and REDD1 in predicting sensitivity to targeted therapies in renal cell carcinoma by Blick, Christopher, Ramachandran, Anassuya, McCormick, Robert, Cranston, David, Harris, Adrian L.

“…Abstract There are currently 6 FDA approved therapies in metastatic renal cell carcinoma and their introduction has improved both time to progression and…”
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An in vivo hypoxia metagene identifies the novel hypoxia inducible factor target gene SLCO1B3 by Ramachandran, Anassuya, Betts, Guy, Bhana, Sara, Helme, Gemma, Blick, Christopher, Moller-Levet, Carla, Saunders, Emma, Valentine, Helen, Pepper, Stuart, Miller, Crispin J, Buffa, Francesca, Harris, Adrian L, West, Catharine M.L

“…Abstract A hypoxia-associated gene signature (metagene) was previously derived via in vivo data-mining. In this study, we aimed to investigate whether this…”
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Abstract LB-440: Low density array profiling of head and neck squamous cell carcinoma utilizing a 25-gene signature can reliably identify hypoxic tumors by Williamson, Amanda, Betts, Guy NJ, Patiar, Shalini, Valentine, Helen R., Irlam, Joely J., Ramachandran, Anassuya, Merve, Ashirwad, Homer, Jarrod J., Moller-Levet, Carla, Buffa, Franscesca M., Hall, Gillian, Miller, Crispin J., Harris, Adrian L., West, Catharine ML

“…Abstract Purpose: Administering hypoxia modifying therapy to patients with head and neck squamous cell carcinoma (HNSCC) improves outcomes in those with…”
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Microarrays--analysis of signaling pathways by Ramachandran, Anassuya, Black, Michael A, Shelling, Andrew N, Love, Donald R

“…Microarrays provide a powerful means of analyzing the expression level of multiple transcripts in two sample populations. In this study, we have used…”
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Cadherin-17 is required to maintain pronephric duct integrity during zebrafish development by Horsfield, Julia, Ramachandran, Anassuya, Reuter, Katja, LaVallie, Edward, Collins-Racie, Lisa, Crosier, Kathryn, Crosier, Philip

“…We have isolated a zebrafish cadherin that is orthologous to human LI-cadherin ( CDH17). Zebrafish cdh17 is expressed exclusively in the pronephric ducts…”
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