One-pot synthesis of fluorine containing 3-cyano/ethoxycarbonyl-2-methyl-benzo[ b]furans

Fluoro-substituted 3-cyano-2-methyl-benzo[ b]furans and ethyl 2-methyl-benzo[ b]furan-3-carboxylates are conveniently prepared in a single step in good yield by the microwave induced tandem intramolecular Wittig and Claisen rearrangement reactions of the corresponding [(aryloxyacetyl) (cyano) methyl...

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Bibliographic Details
Published in:Tetrahedron Vol. 60; no. 52; pp. 12231 - 12237
Main Authors: RamaRao, V.V.V.N.S., Venkat Reddy, G., Maitraie, D., Ravikanth, S., Yadla, R., Narsaiah, B., Shanthan Rao, P.
Format: Journal Article
Language:English
Published: Elsevier Ltd 20-12-2004
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Summary:Fluoro-substituted 3-cyano-2-methyl-benzo[ b]furans and ethyl 2-methyl-benzo[ b]furan-3-carboxylates are conveniently prepared in a single step in good yield by the microwave induced tandem intramolecular Wittig and Claisen rearrangement reactions of the corresponding [(aryloxyacetyl) (cyano) methylene] triphenylphosphorane and [(aryloxyacetyl) (ethoxycarbonyl) methylene] triphenylphosphoranes, respectively. Graphical Abstract
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2004.10.019