Search Results - "Ramírez‐Espinosa, Juan José"

Ursolic acid derivatives as potential antidiabetic agents: In vitro, in vivo, and in silico studies by Guzmán‐Ávila, Ricardo, Flores‐Morales, Virginia, Paoli, Paolo, Camici, Guido, Ramírez‐Espinosa, Juan José, Cerón‐Romero, Litzia, Navarrete‐Vázquez, Gabriel, Hidalgo‐Figueroa, Sergio, Yolanda Rios, Maria, Villalobos‐Molina, Rafael, Estrada‐Soto, Samuel

“…Hit, Lead & Candidate Discovery Protein tyrosine phosphatase 1B (PTP‐1B) has attracted interest as a novel target for the treatment of type 2 diabetes, this…”
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Antidiabetic activity of some pentacyclic acid triterpenoids, role of PTP–1B: In vitro, in silico, and in vivo approaches by Ramírez-Espinosa, Juan José, Rios, Maria Yolanda, López-Martínez, Sugey, López-Vallejo, Fabian, Medina-Franco, José L., Paoli, Paolo, Camici, Guido, Navarrete-Vázquez, Gabriel, Ortiz-Andrade, Rolffy, Estrada-Soto, Samuel

“…The aim of the current study was to investigate the oral antidiabetic activity of four structurally-related triterpenic acids: ursolic (RE-01), oleanolic…”
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Chrysin Induces Antidiabetic, Antidyslipidemic and Anti-Inflammatory Effects in Athymic Nude Diabetic Mice by Ramírez-Espinosa, Juan José, Saldaña-Ríos, Johann, García-Jiménez, Sara, Villalobos-Molina, Rafael, Ávila-Villarreal, Gabriela, Rodríguez-Ocampo, Angélica Nallelhy, Bernal-Fernández, Germán, Estrada-Soto, Samuel

“…Extensive knowledge of diabetes and its complications is helpful to find new drugs for proper treatment to stop degenerative changes derived from this disease…”
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Synthesis and In Vitro AMPK Activation of Cycloalkyl/Alkarylbiguanides with Robust In Vivo Antihyperglycemic Action by Navarrete-Vázquez, Gabriel, Estrada-Soto, Samuel, Carvajal, Karla, Centurión, David, Rivera-Leyva, Julio C., Ramírez-Espinosa, Juan José, Rosales-Ortega, Edgar, Martínez-Conde, Carlos, Gutierrez-Lara, Erika, Ortega-Cuellar, Daniel

“…This work describes the design, synthesis in one step, and the in vitro, in vivo, and in silico antidiabetic evaluation of a series of ten alicyclic and…”
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Vasorelaxant effect of Valeriana edulis ssp. procera (Valerianaceae) and its mode of action as calcium channel blocker by Estrada-Soto, Samuel, Rivera-Leyva, Julio, Ramírez-Espinosa, Juan José, Castillo-España, Patricia, Aguirre-Crespo, Francisco, Hernández-Abreu, Oswaldo

“…Objectives  The aim was to evaluate the relaxant effect of extracts from Valeriana edulis and determine the possible mechanism of action of the hexanic extract…”
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Synthesis and molecular docking of N′-arylidene-5-(4-chlorophenyl)-1-(3,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carbohydrazides as novel hypoglycemic and antioxidant dual agents by Hernández-Vázquez, Eduardo, Salgado-Barrera, Sandybel, Ramírez-Espinosa, Juan José, Estrada-Soto, Samuel, Hernández-Luis, Francisco

“…[Display omitted] •Ten pyrazole-based hybrids were synthesized as hypoglycemic and antioxidant entities.•Compounds bearing a 4-hydroxy group showed antioxidant…”
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Synthesis, in vitro, in silico and in vivo hypoglycemic and lipid-lowering effects of 4-benzyloxy-5-benzylidene-1,3-thiazolidine-2,4-diones mediated by dual PPAR α/γ modulation by Madrigal-Angulo, José Luis, Ménez-Guerrero, Carlos, Estrada-Soto, Samuel, Ramírez-Espinosa, Juan José, Almanza-Pérez, Julio César, León-Rivera, Ismael, Hernández-Núñez, Emanuel, Aguirre-Vidal, Yoshajandith, Flores-León, Carlos D., Aguayo-Ortíz, Rodrigo, Navarrete-Vazquez, Gabriel

“…[Display omitted] In current work, we prepared a series of nine 4-benzyloxy-5-benzylidene-1,3-thiazolidine-2,4-diones using a two-step pathway. Compounds 1–9…”
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Synthesis and evaluation of thiazolidine-2,4-dione/benzazole derivatives as inhibitors of protein tyrosine phosphatase 1B (PTP-1B): Antihyperglycemic activity with molecular docking study by Hidalgo-Figueroa, Sergio, Estrada-Soto, Samuel, Ramírez-Espinosa, Juan José, Paoli, Paolo, Lori, Giulia, León-Rivera, Ismael, Navarrete-Vázquez, Gabriel

“…[Display omitted] •Thiazolidine-2,4-dione derivatives possess important PTP-1B inhibitory activity.•Compound 1 showed in vivo antihyperglycemic…”
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Synthesis, hypoglycemic activity and molecular modeling studies of pyrazole-3-carbohydrazides designed by a CoMFA model by Hernández-Vázquez, Eduardo, Aguayo-Ortiz, Rodrigo, Ramírez-Espinosa, Juan José, Estrada-Soto, Samuel, Hernández-Luis, Francisco

“…Diabetes and obesity are two universal health problems that constitute a research objective of several groups due to the lack of efficient and safe drug…”
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Synthesis of oleanolic acid derivatives: In vitro, in vivo and in silico studies for PTP-1B inhibition by Ramírez-Espinosa, Juan José, Rios, Maria Yolanda, Paoli, Paolo, Flores-Morales, Virginia, Camici, Guido, Rosa-Lugo, Vianey de la, Hidalgo-Figueroa, Sergio, Navarrete-Vázquez, Gabriel, Estrada-Soto, Samuel

“…Non-insulin dependent diabetes mellitus is a multifactorial disease that links different metabolic routes; a point of convergence is the enzyme PTP-1B which…”
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1,5-Diarylpyrazole and vanillin hybrids: Synthesis, biological activity and DFT studies by Hernández-Vázquez, Eduardo, Castañeda-Arriaga, Romina, Ramírez-Espinosa, Juan José, Medina-Campos, Omar Noel, Hernández-Luis, Francisco, Chaverri, José Pedraza, Estrada-Soto, Samuel

“…Herein, we report the design and synthesis of 13 diarylpyrazole hybrids with vanillin constructed as dual compounds against oxidative stress and diabetes…”
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Synthesis, in vitro and in silico studies of a PPARγ and GLUT-4 modulator with hypoglycemic effect by Navarrete-Vázquez, Gabriel, Torres-Gómez, Héctor, Hidalgo-Figueroa, Sergio, Ramírez-Espinosa, Juan José, Estrada-Soto, Samuel, Medina-Franco, José L., León-Rivera, Ismael, Alarcón-Aguilar, Francisco Javier, Almanza-Pérez, Julio César

“…Compound {4-[({4-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy}acetyl)amino]phenoxy}acetic acid (1) was prepared and the in vitro relative…”
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Synthesis of 2-{2-[(α/β-naphthalen-1-ylsulfonyl)amino]-1,3-thiazol-4-yl} acetamides with 11β-hydroxysteroid dehydrogenase inhibition and in combo antidiabetic activities by Navarrete-Vázquez, Gabriel, Morales-Vilchis, Maria Guadalupe, Estrada-Soto, Samuel, Ramírez-Espinosa, Juan José, Hidalgo-Figueroa, Sergio, Nava-Zuazo, Carlos, Tlahuext, Hugo, Leon-Rivera, Ismael, Medina-Franco, José L., López-Vallejo, Fabian, Webster, Scott P., Binnie, Margaret, Ortiz-Andrade, Rolffy, Moreno-Diaz, Hermenegilda

“…Compounds 1–10 were designed using a bioisosteric approach and were prepared using a short synthetic route. The in vitro inhibitory activity of the compounds…”
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Antihyperglycemic and sub-chronic antidiabetic actions of morolic and moronic acids, in vitro and in silico inhibition of 11β-HSD 1 by Ramírez-Espinosa, Juan José, García-Jiménez, Sara, Rios, Maria Yolanda, Medina-Franco, José L., López-Vallejo, Fabián, Webster, Scott P., Binnie, Margareth, Ibarra-Barajas, Maximiliano, Ortiz-Andrade, Rolffy, Estrada-Soto, Samuel

“…Morolic (1) and moronic (2) acids are the main constituents of acetonic extract from Phoradendron reichenbachianum (Loranthaceae), a medicinal plant used in…”
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