Search Results - "Ram, Mary K."

Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor by Hatada, Marcos H, Lu, Xiaode, Laird, Ellen R, Green, Jeremy, Morgenstern, Jay P, Lou, Meizhen, Marr, Chris S, Phillips, Thomas B, Ram, Mary K, Theriault, Kelly, Zoller, Mark J, Karas, Jennifer L

“…The crystal structure of the tandem SH2 domains of human ZAP-70 in complex with a peptide derived from the zeta-subunit of the T-cell receptor reveals an…”
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Investigating Protein−Ligand Interactions with a Mutant FKBP Possessing a Designed Specificity Pocket by Yang, Wu, Rozamus, Leonard W, Narula, Surinder, Rollins, Carl T, Yuan, Ruth, Andrade, Lawrence J, Ram, Mary K, Phillips, Thomas B, van Schravendijk, Marie Rose, Dalgarno, David, Clackson, Tim, Holt, Dennis A

“…Using structure-based design and protein mutagenesis we have remodeled the FKBP12 ligand binding site to include a sizable, hydrophobic specificity pocket…”
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Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor by Hatada, Marcos H, Lu, Xiaode, Laird, Ellen R, Green, Jeremy, Morgenstern, Jay P, Lou, Meizhen, Marr, Chris S, Phillips, Thomas B, Ram, Mary K, Theriault, Kelly, Zoller, Mark J, Karas, Jennifer L

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Bone-Targeted Src kinase inhibitors: novel pyrrolo- and pyrazolopyrimidine analogues by Sundaramoorthi, Raji, Shakespeare, William C., Keenan, Terence P., Metcalf, Chester A., Wang, Yihan, Mani, Ukti, Taylor, Merry, Liu, Shuangying, Bohacek, Regine S., Narula, Surinder S., Dalgarno, David C., Van Schravandijk, Marie Rose, Violette, Sheila M., Liou, Shuenn, Adams, Susan, Ram, Mary K., Keats, Jeffrey A., Weigele, Manfred, Sawyer, Tomi K.

“…Src tyrosine kinase is a therapeutic target for bone diseases that has been validated by gene knockout studies. Furthermore, in vitro cellular studies…”
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Bone-Targeted pyrido[2,3- d]pyrimidin-7-ones: potent inhibitors of Src tyrosine kinase as novel antiresorptive agents by Vu, Chi B., Luke, George P., Kawahata, Noriyuki, Shakespeare, William C., Wang, Yihan, Sundaramoorthi, Raji, Metcalf, Chester A., Keenan, Terence P., Pradeepan, Selvi, Corpuz, Evelyn, Merry, Taylor, Bohacek, Regine S., Dalgarno, David C., Narula, Surinder S., van Schravendijk, Marie Rose, Ram, Mary K., Adams, Susan, Liou, Shuenn, Keats, Jeffrey A., Violette, Shelia M., Guan, Wei, Weigele, Manfred, Sawyer, Tomi K.

“…The design of bone-targeted pyrido[2,3- d]pyrimidin-7-ones as Src tyrosine kinase inhibitors is described. Leveraging SAR from known compounds and using…”
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Discovery of Potent and Selective SH2 Inhibitors of the Tyrosine Kinase ZAP-70 by Vu, Chi B, Corpuz, Evelyn G, Merry, Taylor J, Pradeepan, Selvaluxmi G, Bartlett, Catherine, Bohacek, Regine S, Botfield, Martyn C, Eyermann, Charles J, Lynch, Berkley A, MacNeil, Ian A, Ram, Mary K, van Schravendijk, Marie Rose, Violette, Shelia, Sawyer, Tomi K

“…A series of 1,2,4-oxadiazole analogues has been shown to be potent and selective SH2 inhibitors of the tyrosine kinase ZAP-70, a potential therapeutic target…”
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Corrigendum to “Bone-Targeted Src Kinase Inhibitors: Novel Pyrrolo- and Pyrazolopyrimidine Analogues”[Bioorg. Med. Chem. Lett. 13 (2003) 3063] by Sundaramoorthi, Raji, Shakespeare, William C, Keenan, Terence P, Metcalf, Chester A, Wang, Yihan, Mani, Ukti, Merry, Taylor, Liu, Shuangying, Bohacek, Regine S, Narula, Surinder S, Dalgarno, David C, Van Schravendijk, Marie Rose, Violette, Shelia M, Liou, Shuenn, Adams, Susan, Ram, Mary K, Keats, Jeffrey A, Weigle, Manfred, Sawyer, Tomi K

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Activation of the high-affinity immunoglobulin E receptor Fc epsilon RI in RBL-2H3 cells is inhibited by Syk SH2 domains by Taylor, J A, Karas, J L, Ram, M K, Green, O M, Seidel-Dugan, C

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Bone-targeted Src kinase inhibitors: Novel pyrrolo- and pyrazolopyrimidine analogues: Recent advances in the design of kinase inhibitors as novel therapeutic agents by SUNDARAMOORTHI, Raji, SHAKESPEARE, William C, DALGARNO, David C, VAN SCHRAVANDIJK, Marie Rose, VIOLETTE, Sheila M, LIOU, Shuenn, ADAMS, Susan, RAM, Mary K, KEATS, Jeffrey A, WEIGELE, Manfred, SAWYER, Tomi K, KEENAN, Terence P, METCALF, Chester A, YIHAN WANG, MANI, Ukti, TAYLOR, Merry, SHUANGYING LIU, BOHACEK, Regine S, NARULA, Surinder S

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Simultaneous Assay of Src SH3 and SH2 Domain Binding Using Different Wavelength Fluorescence Polarization Probes by Lynch, Berkley A., Minor, Charles, Loiacono, Kara A., van Schravendijk, Marie Rose, Ram, Mary K., Sundaramoorthi, Raji, Adams, Susan E., Phillips, Tom, Holt, Dennis, Rickles, Richard J., MacNeil, Ian A.

“…pp60c-src is a prototypical nonreceptor tyrosine kinase and may play a role in diseases as diverse as cancer and osteoporosis. In Src, the SH3 domain (Src…”
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Identification of UDP-Linked Murein Precursors as Contaminants in Recombinant Proteins of Low Molecular Weight by Ram, Mary K., Andrade, Lawrence J., Phillips, Thomas B., van Schravendijk, Marie R.

“…The A280/A260 ratio of a purified protein is frequently used as an indication of the purity of the preparation with respect to nucleic acids. We show here that…”
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Bone-targeted pyrido[2,3-d]pyrimidin-7-ones: Potent inhibitors of Src tyrosine kinase as novel antiresorptive agents: Recent advances in the design of kinase inhibitors as novel therapeutic agents by VU, Chi B, LUKE, George P, MERRY, Taylor, BOHACEK, Regine S, DALGARNO, David C, NARULA, Surinder S, VAN SCHRAVENDIJK, Marie Rose, RAM, Mary K, ADAMS, Susan, LIOU, Shuenn, KEATS, Jeffrey A, VIOLETTE, Shelia M, KAWAHATA, Noriyuki, WEI GUAN, WEIGELE, Manfred, SAWYER, Tomi K, SHAKESPEARE, William C, YIHAN WANG, SUNDARAMOORTHI, Raji, METCALF, Chester A, KEENAN, Terence P, PRADEEPAN, Selvi, CORPUZ, Evelyn

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Interaction of p72 syk with the γ and β Subunits of the High-Affinity Receptor for Immunoglobulin E, FcεRI by Shiue, Lily, Green, J., Green, O. M., Karas, Jennifer L., Morgenstern, Jay P., Ram, Mary K., Taylor, Marta K., Zoller, Mark J., Zydowsky, Lynne D., Bolen, Joseph B., Brugge, Joan S.

“…Activation of protein tyrosine kinases is one of the initial events following aggregation of the high-affinity receptor for immunoglobulin E (Fc«RI) on RBL-2H3…”
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