Search Results - "Ralton, Julie E."

Leishmania major methionine sulfoxide reductase A is required for resistance to oxidative stress and efficient replication in macrophages by Sansom, Fiona M, Tang, Leonie, Ralton, Julie E, Saunders, Eleanor C, Naderer, Thomas, McConville, Malcolm J

“…Leishmania are protozoan parasites that proliferate within the phagolysome of mammalian macrophages. While a number of anti-oxidant systems in these parasites…”
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Synthesis, Structural Elucidation, And Biochemical Analysis of Immunoactive Glucuronosyl Diacylglycerides of Mycobacteria and Corynebacteria by Cao, Benjamin, Chen, Xingqiang, Yamaryo-Botte, Yoshiki, Richardson, Mark B, Martin, Kirstee L, Khairallah, George N, Rupasinghe, Thusita W.T, O’Flaherty, Roisin M, O’Hair, Richard A.J, Ralton, Julie E, Crellin, Paul K, Coppel, Ross L, McConville, Malcolm J, Williams, Spencer J

“…Glucuronosyl diacylglycerides (GlcAGroAc2) are functionally important glycolipids and membrane anchors for cell wall lipoglycans in the Corynebacteria. Here we…”
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Golgi-located NTPDase1 of Leishmania major is required for lipophosphoglycan elongation and normal lesion development whereas secreted NTPDase2 is dispensable for virulence by Sansom, Fiona M, Ralton, Julie E, Sernee, M Fleur, Cohen, Alice M, Hooker, David J, Hartland, Elizabeth L, Naderer, Thomas, McConville, Malcolm J

“…Parasitic protozoa, such as Leishmania species, are thought to express a number of surface and secreted nucleoside triphosphate diphosphohydrolases (NTPDases)…”
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Discovery of inhibitors of Leishmania β-1,2-mannosyltransferases using a click-chemistry-derived guanosine monophosphate library by van der Peet, Phillip, Ralton, Julie E, McConville, Malcolm J, Williams, Spencer J

“…Leishmania spp. are a medically important group of protozoan parasites that synthesize a novel intracellular carbohydrate reserve polymer termed mannogen…”
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Evolution and function of carbohydrate reserve biosynthesis in parasitic protists by Ralton, Julie E., Sernee, M. Fleur, McConville, Malcolm J.

“…Nearly all eukaryotic cells synthesize carbohydrate reserves, such as glycogen, starch, or low-molecular-weight oligosaccharides. However, a number of…”
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Apicoplast-derived isoprenoids are essential for biosynthesis of GPI protein anchors, and consequently for egress and invasion in Plasmodium falciparum by Bulloch, Michaela S, Huynh, Long K, Kennedy, Kit, Ralton, Julie E, McConville, Malcolm J, Ralph, Stuart A

“…Glycophosphatidylinositol (GPI) anchors are the predominant glycoconjugate in Plasmodium parasites, enabling modified proteins to associate with biological…”
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Metabolic stringent response in intracellular stages of Leishmania by Saunders, Eleanor C, Sernee, Marijke F, Ralton, Julie E, McConville, Malcolm J

“…[Display omitted] •Intracellular amastigote stages of Leishmania activate a stringent metabolic response.•The stringent response, triggered by H2O2, involves…”
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Leishmania β-1,2-Mannan Is Assembled on a Mannose-Cyclic Phosphate Primer by Sernee, M. Fleur, Ralton, Julie E., Dinev, Zoran, Khairallah, George N., O'Hair, Richard A., Williams, Spencer J., McConville, Malcolm J.

“…Infective stages of the protozoan parasite Leishmania spp. accumulate a class of β-1,2-mannan oligosaccharides as their major carbohydrate reserve material…”
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The intracellular parasite Toxoplasma gondii depends on the synthesis of long‐chain and very long‐chain unsaturated fatty acids not supplied by the host cell by Ramakrishnan, Srinivasan, Docampo, Melissa D., MacRae, James I., Ralton, Julie E., Rupasinghe, Thusitha, McConville, Malcolm J., Striepen, Boris

“…Summary Apicomplexa are parasitic protozoa that cause important human diseases including malaria, cryptosporidiosis and toxoplasmosis. The replication of these…”
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A Family of Dual-Activity Glycosyltransferase-Phosphorylases Mediates Mannogen Turnover and Virulence in Leishmania Parasites by Sernee, M. Fleur, Ralton, Julie E., Nero, Tracy L., Sobala, Lukasz F., Kloehn, Joachim, Vieira-Lara, Marcel A., Cobbold, Simon A., Stanton, Lauren, Pires, Douglas E.V., Hanssen, Eric, Males, Alexandra, Ward, Tom, Bastidas, Laurence M., van der Peet, Phillip L., Parker, Michael W., Ascher, David B., Williams, Spencer J., Davies, Gideon J., McConville, Malcolm J.

“…Parasitic protists belonging to the genus Leishmania synthesize the non-canonical carbohydrate reserve, mannogen, which is composed of β-1,2-mannan…”
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Acetylation of Trehalose Mycolates Is Required for Efficient MmpL-Mediated Membrane Transport in Corynebacterineae by Yamaryo-Botte, Yoshiki, Rainczuk, Arek K, Lea-Smith, David J, Brammananth, Rajini, van der Peet, Phillip L, Meikle, Peter, Ralton, Julie E, Rupasinghe, Thusita W. T, Williams, Spencer J, Coppel, Ross L, Crellin, Paul K, McConville, Malcolm J

“…Pathogenic species of Mycobacteria and Corynebacteria, including Mycobacterium tuberculosis and Corynebacterium diphtheriae, synthesize complex cell walls that…”
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Central carbon metabolism of Leishmania parasites by Saunders, Eleanor C, DE Souza, David P, Naderer, Thomas, Sernee, Marijke F, Ralton, Julie E, Doyle, Maria A, Macrae, James I, Chambers, Jenny L, Heng, Joanne, Nahid, Amsha, Likic, Vladimir A, McConville, Malcolm J

“…Leishmania spp. are sandfly-transmitted protozoa parasites that cause a spectrum of diseases in humans. Many enzymes involved in Leishmania central carbon…”
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Use of Click Chemistry to Define the Substrate Specificity of Leishmania β-1,2-Mannosyltransferases by van der Peet, Phillip, Gannon, Carlie T, Walker, Ian, Dinev, Zoran, Angelin, Marcus, Tam, Shanna, Ralton, Julie E, McConville, Malcolm J, Williams, Spencer J

“…Leishmania spp. are human pathogens that utilize a novel β-1,2-mannan as their major carbohydrate reserve material. We describe a new approach that combines…”
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Intracellular trafficking of glycosylphosphatidylinositol (GPI)-anchored proteins and free GPIs in Leishmania mexicana by Ralton, Julie E, Mullin, Kylie A, McConville, Malcolm J

“…Free glycosylphosphatidylinositols (GPIs) are an important class of membrane lipids in many pathogenic protozoa. In this study, we have investigated the…”
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Evidence that free GPI glycolipids are essential for growth of Leishmania mexicana by Ilgoutz, Steven C., Zawadzki, Jody L., Ralton, Julie E., McConville, Malcolm J.

“…The cell surface of the parasitic protozoan Leishmania mexicana is coated by glycosylphosphatidylinositol (GPI)‐anchored glycoproteins, a GPI‐anchored…”
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Delineation of Three Pathways of Glycosylphosphatidylinositol Biosynthesis in Leishmania mexicana by Ralton, Julie E., McConville, Malcolm J.

“…Glycosylphosphatidylinositol (GPI) glycolipids are major cell surface constituents in the Leishmania parasites. Distinct classes of GPI are present as membrane…”
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Identification of two N-terminal non-alpha-helical domain motifs important in the assembly of glial fibrillary acidic protein by RALTON, J. E, XIN LU, HUTCHESON, A. M, QUINLAN, R. A

“…The non-alpha-helical N-terminal domain of intermediate filament proteins plays a key role in filament assembly. Previous studies have identified a nonapeptide…”
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The intracellular parasite T oxoplasma gondii depends on the synthesis of long‐chain and very long‐chain unsaturated fatty acids not supplied by the host cell by Ramakrishnan, Srinivasan, Docampo, Melissa D., MacRae, James I., Ralton, Julie E., Rupasinghe, Thusitha, McConville, Malcolm J., Striepen, Boris

“…Apicomplexa are parasitic protozoa that cause important human diseases including malaria, cryptosporidiosis and toxoplasmosis. The replication of these…”
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Discovery of Inhibitors of Leishmania [beta]-1,2-Mannosyltransferases Using a Click-Chemistry-Derived Guanosine Monophosphate Library by van der Peet, Phillip, Ralton, Julie E, McConville, Malcolm J, Williams, Spencer J

“…Leishmania spp. are a medically important group of protozoan parasites that synthesize a novel intracellular carbohydrate reserve polymer termed mannogen…”
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Evidence That Intracellular β1-2 Mannan Is a Virulence Factor in Leishmania Parasites by Ralton, Julie E., Naderer, Thomas, Piraino, Helena L., Bashtannyk, Tanya A., Callaghan, Judy M., McConville, Malcolm J.

“…The protozoan parasite Leishmania mexicana proliferates within macrophage phagolysosomes in the mammalian host. In this study we provide evidence that a novel…”
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