Search Results - "Ralston, Stuart H."

Discontinuation of Denosumab therapy for osteoporosis: A systematic review and position statement by ECTS by Tsourdi, Elena, Langdahl, Bente, Cohen-Solal, Martine, Aubry-Rozier, Bérengere, Eriksen, Erik Fink, Guañabens, Nuria, Obermayer-Pietsch, Barbara, Ralston, Stuart H., Eastell, Richard, Zillikens, M. Carola

“…The optimal duration of osteoporosis treatment is controversial. As opposed to bisphosphonates, denosumab does not incorporate into bone matrix and bone…”
Get full text

Management of Osteogenesis Imperfecta by Ralston, Stuart H, Gaston, Mark S

“…Osteogenesis imperfecta (OI) is the term used to describe a group of rare inherited skeletal disorders characterized by a greatly increased risk of fragility…”
Get full text

Genetic regulation of bone mass and susceptibility to osteoporosis by Ralston, Stuart H, de Crombrugghe, Benoit

“…Osteoporosis is a common disease with a strong genetic component characterized by reduced bone mass and increased risk of fragility fractures. Twin and family…”
Get full text

Genetics of osteoporosis by Ralston, Stuart H.

“…Osteoporosis is a common disease with a strong genetic component characterized by reduced bone mass and an increased risk of fragility fractures. Twin and…”
Get full text

Medical Management of Patients After Atypical Femur Fractures: a Systematic Review and Recommendations From the European Calcified Tissue Society by van de Laarschot, Denise M, McKenna, Malachi J, Abrahamsen, Bo, Langdahl, Bente, Cohen-Solal, Martine, Guañabens, Núria, Eastell, Richard, Ralston, Stuart H, Zillikens, M Carola

“…Abstract Context Atypical femur fractures (AFFs) are serious adverse events associated with bisphosphonates and often show poor healing. Evidence acquisition…”
Get full text

Rare Inherited forms of Paget’s Disease and Related Syndromes by Ralston, Stuart H., Taylor, J. Paul

“…Several rare inherited disorders have been described that show phenotypic overlap with Paget’s disease of bone (PDB) and in which PDB is a component of a…”
Get full text

Bisphosphonates for the Prevention of Fractures in Osteogenesis Imperfecta: Meta‐Analysis of Placebo‐Controlled Trials by Hald, Jannie D, Evangelou, Evangelos, Langdahl, Bente L, Ralston, Stuart H

“…ABSTRACT Bisphosphonates are widely used off‐label in the treatment of patients with osteogenesis imperfecta (OI) with the intention of reducing the risk of…”
Get full text

A Randomized Trial of Vertebroplasty for Osteoporotic Spinal Fractures by Kallmes, David F, Comstock, Bryan A, Heagerty, Patrick J, Turner, Judith A, Wilson, David J, Diamond, Terry H, Edwards, Richard, Gray, Leigh A, Stout, Lydia, Owen, Sara, Hollingworth, William, Ghdoke, Basavaraj, Annesley-Williams, Deborah J, Ralston, Stuart H, Jarvik, Jeffrey G

“…In this randomized trial involving patients with osteoporotic vertebral compression fractures, patients who underwent vertebroplasty had improvements in pain…”
Get full text

Diagnosis and Management of Paget's Disease of Bone in Adults: A Clinical Guideline by Ralston, Stuart H, Corral‐Gudino, Luis, Cooper, Cyrus, Francis, Roger M, Fraser, William D, Gennari, Luigi, Guañabens, Núria, Javaid, M Kassim, Layfield, Robert, O'Neill, Terence W, Russell, R Graham G, Stone, Michael D, Simpson, Keith, Wilkinson, Diana, Wills, Ruth, Zillikens, M Carola, Tuck, Stephen P

“…ABSTRACT An evidence‐based clinical guideline for the diagnosis and management of Paget's disease of bone (PDB) was developed using GRADE methodology, by a…”
Get full text

Effect of Denosumab or Alendronic Acid on the Progression of Aortic Stenosis: A Double-Blind Randomized Controlled Trial by Pawade, Tania A., Doris, Mhairi K., Bing, Rong, White, Audrey C., Forsyth, Laura, Evans, Emily, Graham, Catriona, Williams, Michelle C., van Beek, Edwin J.R., Fletcher, Alison, Adamson, Philip D., Andrews, Jack P.M., Cartlidge, Timothy R.G., Jenkins, William S.A., Syed, Maaz, Fujisawa, Takeshi, Lucatelli, Christophe, Fraser, William, Ralston, Stuart H., Boon, Nicholas, Prendergast, Bernard, Newby, David E., Dweck, Marc R.

“…Valvular calcification is central to the pathogenesis and progression of aortic stenosis, with preclinical and observational studies suggesting that bone…”
Get full text

Heavy cannabis use is associated with low bone mineral density and an increased risk of fractures by Sophocleous, Antonia, PhD, Robertson, Roy, MD, Ferreira, Nuno B., PhD, McKenzie, James, RGN, Fraser, William D., MD, Ralston, Stuart H., MD

“…Abstract Purpose To investigate possible associations between recreational cannabis use and bone health in humans. Methods Cross-sectional study of individuals…”
Get full text

Optineurin Negatively Regulates Osteoclast Differentiation by Modulating NF-κB and Interferon Signaling: Implications for Paget’s Disease by Obaid, Rami, Wani, Sachin E., Azfer, Asim, Hurd, Toby, Jones, Ruth, Cohen, Philip, Ralston, Stuart H., Albagha, Omar M.E.

“…Paget’s disease of bone (PDB) is a common disease characterized by osteoclast activation that leads to various skeletal complications. Susceptibility to PDB is…”
Get full text

Genetic Determinants of Paget’s Disease of Bone by Makaram, Navnit S., Ralston, Stuart H.

“…Purpose of Review To provide an overview of the role of genes and loci that predispose to Paget’s disease of bone and related disorders. Recent Findings…”
Get full text

Combined deficiency of the Cnr1 and Cnr2 receptors protects against age‐related bone loss by osteoclast inhibition by Sophocleous, Antonia, Marino, Silvia, Kabir, Dilruba, Ralston, Stuart H., Idris, Aymen I.

“…Summary The endocannabinoid system plays a role in regulating bone mass and bone cell activity and inactivation of the type 1 (Cnr1) or type 2 (Cnr2)…”
Get full text

Proton Pump Inhibitors Inhibit PHOSPHO1 Activity and Matrix Mineralisation In Vitro by Staines, Katherine A., Myers, Katherine, Little, Kirsty, Ralston, Stuart H., Farquharson, Colin

“…Proton pump inhibitors (PPIs) have been associated with an increased risk of fragility fractures in pharmaco-epidemiological studies. The mechanism is unclear,…”
Get full text

Insertion Mutation in Tnfrsf11a Causes a Paget's Disease–Like Phenotype in Heterozygous Mice and Osteopetrosis in Homozygous Mice by Alonso, Nerea, Wani, Sachin, Rose, Lorraine, van't Hof, Rob J., Ralston, Stuart H., Albagha, Omar M.E.

“…ABSTRACT Early onset familial Paget's disease of bone (EoPDB), familial expansile osteolysis, and expansile skeletal hyperphosphatasia are related disorders…”
Get full text

The TRPV1 ion channel antagonist capsazepine inhibits osteoclast and osteoblast differentiation in vitro and ovariectomy induced bone loss in vivo by Idris, Aymen I, Landao-Bassonga, Euphemie, Ralston, Stuart H

“…Abstract The vanilloid type 1 ion channel (TRPV1) is known to play an important role in the regulation of pain and inflammation. Pharmacological ligands of…”
Get full text

Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget's disease of bone by Albagha, Omar M E, Visconti, Micaela R, Alonso, Nerea, Langston, Anne L, Cundy, Tim, Dargie, Rosemary, Dunlop, Malcolm G, Fraser, William D, Hooper, Michael J, Isaia, Gianluca, Nicholson, Geoff C, del Pino Montes, Javier, Gonzalez-Sarmiento, Rogelio, di Stefano, Marco, Tenesa, Albert, Walsh, John P, Ralston, Stuart H

“…Stuart Ralston and colleagues report results of a genome-wide association study for Paget's disease of bone. Their work identifies common variants at three…”
Get full text

Cerebral Small Vessel Disease Burden Is Increased in Systemic Lupus Erythematosus by Wiseman, Stewart J, Bastin, Mark E, Jardine, Charlotte L, Barclay, Gayle, Hamilton, Iona F, Sandeman, Elaine, Hunt, David, Amft, E Nicole, Thomson, Susan, Belch, Jill F.F, Ralston, Stuart H, Wardlaw, Joanna M

“…BACKGROUND AND PURPOSE—Systemic lupus erythematosus (SLE) increases stroke risk, but the mechanism is uncertain. This study aimed to determine the association…”
Get full text

Protocol of a randomised trial of teriparatide followed by zoledronic acid to reduce fracture risk in adults with osteogenesis imperfecta by Hald, Jannie D, Keerie, Catriona, Weir, Christopher J, Javaid, Muhammad K, Lam, Wayne, Osborne, Patricia, Walsh, Jennifer, Langdahl, Bente L, Ralston, Stuart H

“…IntroductionOsteogenesis imperfecta (OI) is a rare genetic disease associated with multiple fractures throughout life. It is often treated with osteoporosis…”
Get full text