Search Results - "Ralph, Schulz"

Serial monitoring of circulating tumor DNA in patients with primary breast cancer for detection of occult metastatic disease by Olsson, Eleonor, Winter, Christof, George, Anthony, Chen, Yilun, Howlin, Jillian, Tang, Man‐Hung Eric, Dahlgren, Malin, Schulz, Ralph, Grabau, Dorthe, van Westen, Danielle, Fernö, Mårten, Ingvar, Christian, Rose, Carsten, Bendahl, Pär‐Ola, Rydén, Lisa, Borg, Åke, Gruvberger‐Saal, Sofia K, Jernström, Helena, Saal, Lao H

“…Metastatic breast cancer is usually diagnosed after becoming symptomatic, at which point it is rarely curable. Cell‐free circulating tumor DNA (ctDNA) contains…”
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Targeting IRAK4 disrupts inflammatory pathways and delays tumor development in chronic lymphocytic leukemia by Giménez, Neus, Schulz, Ralph, Higashi, Morihiro, Aymerich, Marta, Villamor, Neus, Delgado, Julio, Juan, Manel, López-Guerra, Mònica, Campo, Elias, Rosich, Laia, Seiffert, Martina, Colomer, Dolors

“…Interleukin-1 receptor-associated kinase 4 (IRAK4) plays a critical role in Toll-like receptor (TLR) signal transduction and innate immune responses…”
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Combining ibrutinib and checkpoint blockade improves CD8+ T-cell function and control of chronic lymphocytic leukemia in Em-TCL1 mice by Hanna, Bola S, Yazdanparast, Haniyeh, Demerdash, Yasmin, Roessner, Philipp M, Schulz, Ralph, Lichter, Peter, Stilgenbauer, Stephan, Seiffert, Martina

“…Ibrutinib is a bruton's tyrosine kinase (BTK) inhibitor approved for the treatment of multiple B-cell malignancies, including chronic lymphocytic leukemia…”
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Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome by Nuber, Ulrike A., Kriaucionis, Skirmantas, Roloff, Tim C., Guy, Jacky, Selfridge, Jim, Steinhoff, Christine, Schulz, Ralph, Lipkowitz, Bettina, Ropers, H. Hilger, Holmes, Megan C., Bird, Adrian

“…Rett syndrome (RTT) is a severe form of mental retardation, which is caused by spontaneous mutations in the X-linked gene MECP2. How the loss of MeCP2 function…”
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Divisible designs with dual translation group by Giese, Sabine, Schulz, Ralph-Hardo

“…Many different divisible designs are already known. Some of them possess remarkable automorphism groups, so called dual translation groups. The existence of…”
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Different molecular mechanisms underlie placental overgrowth phenotypes caused by interspecies hybridization, cloning, and Esx1 mutation by Singh, Umashankar, Fohn, Laurel E., Wakayama, Teruhiko, Ohgane, Jun, Steinhoff, Christine, Lipkowitz, Bettina, Schulz, Ralph, Orth, Annie, Ropers, H. Hilger, Behringer, Richard R., Tanaka, Satoshi, Shiota, Kunio, Yanagimachi, Ryuzo, Nuber, Ulrike A., Fundele, Reinald

“…To obtain a deeper insight into the genes and gene networks involved in the development of placentopathies, we have assessed global gene expression in three…”
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Some constructions of divisible designs from Laguerre geometries by Giese, Sabine, Havlicek, Hans, Schulz, Ralph-Hardo

“…In the nineties, A.G. Spera introduced a construction principle for divisible designs. Using this method, we get series of divisible designs from finite…”
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Expression and functional analysis of genes deregulated in mouse placental overgrowth models: Car2 and Ncam1 by Singh, Umashankar, Sun, Tong, Shi, Wei, Schulz, Ralph, Nuber, Ulrike A., Varanou, Aikaterini, Hemberger, Myriam C., Elliott, Rosemary W., Ohta, Hiroshi, Wakayama, Teruhiko, Fundele, Reinald

“…Different causes, such as maternal diabetes, cloning by nuclear transfer, interspecific hybridization, and deletion of some genes such as Esx1, Ipl, or Cdkn1c,…”
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Treg Depletion Licenses T Cell-Driven HEV Neogenesis and Promotes Tumor Destruction by Colbeck, Emily J, Jones, Emma, Hindley, James P, Smart, Kathryn, Schulz, Ralph, Browne, Molly, Cutting, Scott, Williams, Anwen, Parry, Lee, Godkin, Andrew, Ware, Carl F, Ager, Ann, Gallimore, Awen

“…T-cell infiltration into tumors represents a critical bottleneck for immune-mediated control of cancer. We previously showed that this bottleneck can be…”
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TLR9 expression in chronic lymphocytic leukemia identifies a promigratory subpopulation and novel therapeutic target by Kennedy, Emma, Coulter, Eve, Halliwell, Emma, Profitos-Peleja, Nuria, Walsby, Elisabeth, Clark, Barnaby, Phillips, Elizabeth H., Burley, Thomas A., Mitchell, Simon, Devereux, Stephen, Fegan, Christopher D., Jones, Christopher I., Johnston, Rosalynd, Chevassut, Tim, Schulz, Ralph, Seiffert, Martina, Agathanggelou, Angelo, Oldreive, Ceri, Davies, Nicholas, Stankovic, Tatjana, Liloglou, Triantafillos, Pepper, Chris, Pepper, Andrea G.S.

“…Chronic lymphocytic leukemia (CLL) remains incurable despite B-cell receptor–targeted inhibitors revolutionizing treatment. This suggests that other signaling…”
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Autoantigen-Harboring Apoptotic Cells Hijack the Coinhibitory Pathway of T Cell Activation by Yakoub, Abraam M., Schulz, Ralph, Seiffert, Martina, Sadek, Mark

“…Apoptosis is an important physiological process in development and disease. Apoptotic cells (ACs) are a major source of self-antigens, but ACs usually evade…”
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TBET‐expressing Th1 CD4+ T cells accumulate in chronic lymphocytic leukaemia without affecting disease progression in Eµ‐TCL1 mice by Roessner, Philipp M., Hanna, Bola S., Öztürk, Selcen, Schulz, Ralph, Llaó Cid, Laura, Yazdanparast, Haniyeh, Scheffold, Annika, Colomer, Dolors, Stilgenbauer, Stephan, Lichter, Peter, Seiffert, Martina

“…Summary Chronic lymphocytic leukaemia (CLL) is associated with alterations in T cell number, subset distribution and function. Among these changes, an increase…”
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Combining ibrutinib and checkpoint blockade improves CD8+ T-cell function and control of chronic lymphocytic leukemia in E-TCL1 mice by Hanna, Bola S., Yazdanparast, Haniyeh, Demerdash, Yasmin, Roessner, Philipp M., Schulz, Ralph, Lichter, Peter, Stilgenbauer, Stephan, Seiffert, Martina

“…Ibrutinib is a Bruton’s tyrosine kinase (BTK) inhibitor approved for the treatment of multiple B-cell malignancies, including chronic lymphocytic leukemia…”
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The Sweden Cancerome Analysis Network - Breast (SCAN-B) Initiative: a large-scale multicenter infrastructure towards implementation of breast cancer genomic analyses in the clinical routine by Saal, Lao H, Vallon-Christersson, Johan, Häkkinen, Jari, Hegardt, Cecilia, Grabau, Dorthe, Winter, Christof, Brueffer, Christian, Tang, Man-Hung Eric, Reuterswärd, Christel, Schulz, Ralph, Karlsson, Anna, Ehinger, Anna, Malina, Janne, Manjer, Jonas, Malmberg, Martin, Larsson, Christer, Rydén, Lisa, Loman, Niklas, Borg, Åke

“…Breast cancer exhibits significant molecular, pathological, and clinical heterogeneity. Current clinicopathological evaluation is imperfect for predicting…”
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Abstract LB-083: Targeting IRAK4 disrupts inflammatory pathways and tumor microenvironment in chronic lymphocytic leukemia regardless MYD88 mutational status by Rosich, Laia, Gimenez, Neus, Schulz, Ralph, Higashi, Morihiro, Aymerich, Marta, Lopez, Monica, Juan, Manel, Seiffert, Martina, Campo, Elias, Colomer, Dolors

“…BACKGROUND & AIM. Interleukin-1 receptor-associated kinase 4 (IRAK4) plays a critical role in Toll-like receptor (TLR) signal transduction and the innate…”
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Proinflammatory activity of VEGF-targeted treatment through reversal of tumor endothelial cell anergy by Nowak-Sliwinska, Patrycja, van Beijnum, Judy R., Griffioen, Christian J., Huinen, Zowi R., Sopesens, Nadine Grima, Schulz, Ralph, Jenkins, Samir V., Dings, Ruud P. M., Groenendijk, Floris H., Huijbers, Elisabeth J. M., Thijssen, Victor L. J. L., Jonasch, Eric, Vyth-Dreese, Florry A., Jordanova, Ekaterina S., Bex, Axel, Bernards, René, de Gruijl, Tanja D., Griffioen, Arjan W.

“…Purpose Ongoing angiogenesis renders the tumor endothelium unresponsive to inflammatory cytokines and interferes with adhesion of leukocytes, resulting in…”
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Targeting IRAK4 Disrupts Inflammatory Pathways and Delays Tumor Development in Chronic Lymphocytic Leukemia by Giménez Carabaza, Neus, Laia, Rosich, Ralph, Schulz, Morihiro, Higashi, Aymerich, Marta, Villamor, Neus, Delgado, Julio, Juan, Manel, Lopez-Guerra, Monica, Campo, Elias, Seiffert, Martina, Colomer, Dolors

“…Interleukin-1 receptor-associated kinase 4 (IRAK4) plays a critical role in Toll-like receptor (TLR) signal transduction and the innate immune responses…”
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CLL Exosome-Derived Y RNA hY4 Induces TLR7/8-Mediated Inflammation and PD-L1 Expression in Monocytes by Haderk, Franziska, Llao Cid, Laura, Iskar, Murat, Schulz, Ralph, Goebel, Maria, Duerig, Jan, Stilgenbauer, Stephan, Zapatka, Marc, Lichter, Peter, Seiffert, Martina

“…Chronic lymphocytic leukemia (CLL) is a B-cell malignancy associated with an inflammatory milieu and impaired anti-tumor immunity. Both in human CLL samples…”
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Check character systems over groups and orthogonal Latin squares by Schulz, Ralph-Hardo

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Abstract LB-77: Measurement of tumor-specific chromosomal rearrangements in serial blood samples to monitor breast cancer burden and detect occult metastasis by Olsson, Eleonor, Winter, Christof, George, Anthony, Chen, Yilun, Tang, Man-Hung Eric, Dahlgren, Malin, Schulz, Ralph, Fernö, Mårten, Rose, Carsten, Howlin, Jillian, Ingvar, Christian, Rydén, Lisa, Borg, Åke, Gruvberger-Saal, Sofia K., Jernström, Helena, Saal, Lao H.

“…Malignant cells release into the blood circulation their naked DNA, a potential biomarker containing tumor-specific chromosomal rearrangements. These…”
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