Search Results - "Ralph, N."

The role of type 2 diabetes in neurodegeneration by Verdile, Giuseppe, Fuller, Stephanie J, Martins, Ralph N

“…Abstract A growing body of evidence links type-2 diabetes (T2D) with dementia and neurodegenerative diseases such as Alzheimer's disease (AD). AD is the most…”
Get full text

Plasma glial fibrillary acidic protein is elevated in cognitively normal older adults at risk of Alzheimer’s disease by Chatterjee, Pratishtha, Pedrini, Steve, Stoops, Erik, Goozee, Kathryn, Villemagne, Victor L., Asih, Prita R., Verberk, Inge M. W., Dave, Preeti, Taddei, Kevin, Sohrabi, Hamid R., Zetterberg, Henrik, Blennow, Kaj, Teunissen, Charlotte E., Vanderstichele, Hugo M., Martins, Ralph N.

“…Glial fibrillary acidic protein (GFAP), an astrocytic cytoskeletal protein, can be measured in blood samples, and has been associated with Alzheimer’s disease…”
Get full text

Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer's Disease by Newsholme, Philip, Fraser, Paul E., Wijesekara, Nadeeja, Rowles, Joanne, Sabale, Miheer, Medic, Sandra, Cruzat, Vinicius F., Keane, Kevin N., Verdile, Giuseppe, Martins, Ralph N.

“…Type 2 diabetes (T2DM), Alzheimer’s disease (AD), and insulin resistance are age-related conditions and increased prevalence is of public concern. Recent…”
Get full text

Cerebrospinal fluid biomarkers for understanding multiple aspects of Alzheimer’s disease pathogenesis by Dhiman, Kunal, Blennow, Kaj, Zetterberg, Henrik, Martins, Ralph N., Gupta, Veer Bala

“…Alzheimer’s disease (AD) is a multifactorial age-related brain disease. Numerous pathological events run forth in the brain leading to AD. There is an initial…”
Get full text

Diagnostic and prognostic plasma biomarkers for preclinical Alzheimer's disease by Chatterjee, Pratishtha, Pedrini, Steve, Ashton, Nicholas J., Tegg, Michelle, Goozee, Kathryn, Singh, Abhay K., Karikari, Thomas K., Simrén, Joel, Vanmechelen, Eugeen, Armstrong, Nicola J., Hone, Eugene, Asih, Prita R., Taddei, Kevin, Doré, Vincent, Villemagne, Victor L., Sohrabi, Hamid R., Zetterberg, Henrik, Masters, Colin L., Blennow, Kaj, Martins, Ralph N.

“…Introduction This study involved a parallel comparison of the diagnostic and longitudinal monitoring potential of plasma glial fibrillary acidic protein…”
Get full text

Clinical and cognitive trajectories in cognitively healthy elderly individuals with suspected non-Alzheimer's disease pathophysiology (SNAP) or Alzheimer's disease pathology: a longitudinal study by Burnham, Samantha C, PhD, Bourgeat, Pierrick, PhD, Doré, Vincent, PhD, Savage, Greg, Prof, Brown, Belinda, PhD, Laws, Simon, PhD, Maruff, Paul, Prof, Salvado, Olivier, PhD, Ames, David, Prof, Martins, Ralph N, Prof, Masters, Colin L, Prof, Rowe, Christopher C, Prof, Villemagne, Victor L, Dr

“…Summary Background Brain amyloid β (Aβ) deposition and neurodegeneration have been documented in about 50–60% of cognitively healthy elderly individuals (aged…”
Get full text

High‐density lipoprotein‐related cholesterol metabolism in Alzheimer’s disease by Pedrini, Steve, Chatterjee, Pratishtha, Hone, Eugene, Martins, Ralph N.

“…High‐density lipoproteins (HDL) are a heterogeneous class of molecules whose main function is to remove excess cholesterol through a mechanism called reverse…”
Get full text

A pilot prospective cohort study using experimental quantification of early peripheral nerve regeneration with high-frequency three-dimensional tomographic ultrasound (HFtUS) by Murphy, Ralph N. A., Rogers, Steven K., Bhatti, Waqar, Wong, Jason K., Reid, Adam J.

“…Quantification of peripheral nerve regeneration after injury relies upon subjective outcome measures or electrophysiology assessments requiring fully…”
Get full text

Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease by Huynh, Kevin, Lim, Wei Ling Florence, Giles, Corey, Jayawardana, Kaushala S., Salim, Agus, Mellett, Natalie A., Smith, Adam Alexander T., Olshansky, Gavriel, Drew, Brian G., Chatterjee, Pratishtha, Martins, Ian, Laws, Simon M., Bush, Ashley I., Rowe, Christopher C., Villemagne, Victor L., Ames, David, Masters, Colin L., Arnold, Matthias, Nho, Kwangsik, Saykin, Andrew J., Baillie, Rebecca, Han, Xianlin, Kaddurah-Daouk, Rima, Martins, Ralph N., Meikle, Peter J.

“…Changes to lipid metabolism are tightly associated with the onset and pathology of Alzheimer’s disease (AD). Lipids are complex molecules comprising many…”
Get full text

Potential of coconut oil and medium chain triglycerides in the prevention and treatment of Alzheimer’s disease by Chatterjee, Pratishtha, Fernando, Malika, Fernando, Binosha, Dias, Cintia B., Shah, Tejal, Silva, Renuka, Williams, Shehan, Pedrini, Steve, Hillebrandt, Heidi, Goozee, Kathryn, Barin, Edward, Sohrabi, Hamid R., Garg, Manohar, Cunnane, Stephen, Martins, Ralph N.

“…•Brain glucose hypometabolism is a major early hallmark of AD.•CO is a rich source of MCT, and ketone bodies arise from MCT metabolism.•Ketone bodies serve as…”
Get full text

Validation of Plasma Amyloid-β 42/40 for Detecting Alzheimer Disease Amyloid Plaques by Li, Yan, Schindler, Suzanne E., Bollinger, James G., Ovod, Vitaliy, Mawuenyega, Kwasi G., Weiner, Michael W., Shaw, Leslie M., Masters, Colin L., Fowler, Christopher J., Trojanowski, John Q., Korecka, Magdalena, Martins, Ralph N., Janelidze, Shorena, Hansson, Oskar, Bateman, Randall J.

“…To determine the diagnostic accuracy of a plasma Aβ42/Aβ40 assay in classifying amyloid PET status across global research studies using samples collected by…”
Get full text

PRKAG2 Gene Expression Is Elevated and its Protein Levels Are Associated with Increased Amyloid-β Accumulation in the Alzheimer's Disease Brain by Bharadwaj, Prashant, Martins, Ralph N

“…Increased amyloid-β (Aβ) accumulation associated with abnormal autophagy-lysosomal activity and nutrient kinase dysregulation are common features in…”
Get more information

Impact of Aging on the Auditory System and Related Cognitive Functions: A Narrative Review by Jayakody, Dona M P, Friedland, Peter L, Martins, Ralph N, Sohrabi, Hamid R

“…Age-related hearing loss (ARHL), presbycusis, is a chronic health condition that affects approximately one-third of the world's population. The peripheral and…”
Get full text

Bolivia's lithium frontier: Can public private partnerships deliver a minerals boom for sustainable development? by Hancock, L., Ralph, N., Ali, S.H.

“…Lithium is central at least in the short term, for transitions to renewable energy. Substantial deposits reside in South America's 'lithium triangle' in…”
Get full text

Plasma high‐density lipoprotein cargo is altered in Alzheimer's disease and is associated with regional brain volume by Pedrini, Steve, Doecke, James D., Hone, Eugene, Wang, Penghao, Thota, Rohith, Bush, Ashley I., Rowe, Christopher C., Dore, Vincent, Villemagne, Victor L., Ames, David, Rainey‐Smith, Stephanie, Verdile, Giuseppe, Sohrabi, Hamid R., Raida, Manfred R., Taddei, Kevin, Gandy, Sam, Masters, Colin L., Chatterjee, Pratishtha, Martins, Ralph N.

“…Cholesterol levels have been repeatedly linked to Alzheimer's Disease (AD), suggesting that high levels could be detrimental, but this effect is likely…”
Get full text

Curcumin and cognition: a randomised, placebo-controlled, double-blind study of community-dwelling older adults by Rainey-Smith, Stephanie R., Brown, Belinda M., Sohrabi, Hamid R., Shah, Tejal, Goozee, Kathryn G., Gupta, Veer B., Martins, Ralph N.

“…Curcumin therapy in animals has produced positive cognitive and behavioural outcomes; results of human trials, however, have been inconsistent. In this study,…”
Get full text

Innovative diagnostic tools for early detection of Alzheimer's disease by Laske, Christoph, Sohrabi, Hamid R, Frost, Shaun M, López-de-Ipiña, Karmele, Garrard, Peter, Buscema, Massimo, Dauwels, Justin, Soekadar, Surjo R, Mueller, Stephan, Linnemann, Christoph, Bridenbaugh, Stephanie A, Kanagasingam, Yogesan, Martins, Ralph N, O'Bryant, Sid E

“…Abstract Current state-of-the-art diagnostic measures of Alzheimer's disease (AD) are invasive (cerebrospinal fluid analysis), expensive (neuroimaging) and…”
Get full text

Dietary Supplementation with Curcumin Reduce Circulating Levels of Glycogen Synthase Kinase-3β and Islet Amyloid Polypeptide in Adults with High Risk of Type 2 Diabetes and Alzheimer's Disease by Thota, Rohith N, Rosato, Jessica I, Dias, Cintia B, Burrows, Tracy L, Martins, Ralph N, Garg, Manohar L

“…Dietary supplementation with curcumin has been previously reported to have beneficial effects in people with insulin resistance, type 2 diabetes (T2D) and…”
Get full text

Enhancing Cognitive Functioning in Healthly Older Adults: a Systematic Review of the Clinical Significance of Commercially Available Computerized Cognitive Training in Preventing Cognitive Decline by Shah, Tejal M., Weinborn, Michael, Verdile, Giuseppe, Sohrabi, Hamid R., Martins, Ralph N.

“…Successfully assisting older adults to maintain or improve cognitive function, particularly when they are dealing with neurodegenerative disorders such as…”
Get full text

The Relationship between Sleep Quality and Brain Amyloid Burden by Brown, Belinda M, Rainey-Smith, Stephanie R, Villemagne, Victor L, Weinborn, Michael, Bucks, Romola S, Sohrabi, Hamid R, Laws, Simon M, Taddei, Kevin, Macaulay, S Lance, Ames, David, Fowler, Christopher, Maruff, Paul, Masters, Colin L, Rowe, Christopher C, Martins, Ralph N

“…To evaluate the association between self-reported sleep quality and levels of brain β-amyloid (Aβ) burden, and to determine the effect of the apolipoprotein E…”
Get full text