Two convenient regioselective syntheses of 1- N-alkyl-3-aryl-4-[pyrimidin-4-yl]-pyrazoles

Two regioselective synthetic routes for 1- N-alkyl-3-aryl-4-[pyrimidin-4-yl]-pyrazoles of generic formula 1 were developed. These highly efficient and scalable routes circumvent the generally observed poor regioselectivity for the pyrazole alkylation. Two regioselective synthetic routes for 1- N-alk...

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Bibliographic Details
Published in:	Tetrahedron letters Vol. 50; no. 13; pp. 1377 - 1380
Main Authors:	Ralph, Jeffrey M., Faitg, Thomas H., Silva, Domingos J., Feng, Yanhong, Blackledge, Charles W., Adams, Jerry L.
Format:	Journal Article
Language:	English
Published:	Elsevier Ltd 01-04-2009
Online Access:	Get full text
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Summary:	Two regioselective synthetic routes for 1- N-alkyl-3-aryl-4-[pyrimidin-4-yl]-pyrazoles of generic formula 1 were developed. These highly efficient and scalable routes circumvent the generally observed poor regioselectivity for the pyrazole alkylation. Two regioselective synthetic routes for 1- N-alkyl-3-aryl-4-[pyrimidin-4-yl]-pyrazoles of generic formula 1 were developed. These highly efficient and scalable routes circumvent the generally observed poor regioselectivity for the pyrazole alkylation.
ISSN:	0040-4039 1873-3581
DOI:	10.1016/j.tetlet.2008.12.113