Search Results - "Ralph, J."

Tumor Microenvironment, Metabolism, and Immunotherapy by DeBerardinis, Ralph J

“…The newly diversified experimental strategies to treat cancer include those that involve tweaks to host immunity. A recently described strategy, conducted in…”
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Mechanisms and Implications of Metabolic Heterogeneity in Cancer by Kim, Jiyeon, DeBerardinis, Ralph J.

“…Tumors display reprogrammed metabolic activities that promote cancer progression. We currently possess a limited understanding of the processes governing tumor…”
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Metabolic reprogramming and cancer progression by Faubert, Brandon, Solmonson, Ashley, DeBerardinis, Ralph J

“…Metabolic reprogramming is a hallmark of malignancy. As our understanding of the complexity of tumor biology increases, so does our appreciation of the…”
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Lipoic acid metabolism and mitochondrial redox regulation by Solmonson, Ashley, DeBerardinis, Ralph J.

“…Lipoic acid is an essential cofactor for mitochondrial metabolism and is synthesized de novo using intermediates from mitochondrial fatty-acid synthesis type…”
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Cellular Metabolism and Disease: What Do Metabolic Outliers Teach Us? by DeBerardinis, Ralph J., Thompson, Craig B.

“…An understanding of metabolic pathways based solely on biochemistry textbooks would underestimate the pervasive role of metabolism in essentially every aspect…”
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Metabolic pathways promoting cancer cell survival and growth by Boroughs, Lindsey K., DeBerardinis, Ralph J.

“…Burroughs and DeBerardinis discuss the metabolic pathways that tumour cells employ to promote their survival and proliferation, and present the current…”
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Understanding the Intersections between Metabolism and Cancer Biology by Vander Heiden, Matthew G., DeBerardinis, Ralph J.

“…Transformed cells adapt metabolism to support tumor initiation and progression. Specific metabolic activities can participate directly in the process of…”
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Fundamentals of cancer metabolism by DeBerardinis, Ralph J, Chandel, Navdeep S

“…Tumors reprogram pathways of nutrient acquisition and metabolism to meet the bioenergetic, biosynthetic, and redox demands of malignant cells. These…”
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Glutamine and cancer: cell biology, physiology, and clinical opportunities by Hensley, Christopher T, Wasti, Ajla T, DeBerardinis, Ralph J

“…Glutamine is an abundant and versatile nutrient that participates in energy formation, redox homeostasis, macromolecular synthesis, and signaling in cancer…”
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Applications of metabolomics to study cancer metabolism by Kaushik, Akash K., DeBerardinis, Ralph J.

“…Reprogrammed metabolism supports tumor growth and provides a potential source of therapeutic targets and disease biomarkers. Mass spectrometry-based…”
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The Society of Thoracic Surgeons 2017 Clinical Practice Guidelines for the Surgical Treatment of Atrial Fibrillation by Badhwar, Vinay, MD, Rankin, J. Scott, MD, Damiano, Ralph J., MD, Gillinov, A. Marc, MD, Bakaeen, Faisal G., MD, Edgerton, James R., MD, Philpott, Jonathan M., MD, McCarthy, Patrick M., MD, Bolling, Steven F., MD, Roberts, Harold G., MD, Thourani, Vinod H., MD, Suri, Rakesh M., MD, DPhil, Shemin, Richard J., MD, Firestone, Scott, MS, Ad, Niv, MD

“…Executive Summary Surgical ablation for atrial fibrillation (AF) can be performed without additional risk of operative mortality or major morbidity, and is…”
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Minimally Invasive Versus Open Laminectomy for Lumbar Stenosis: A Systematic Review and Meta-Analysis by Phan, Kevin, Mobbs, Ralph J

“…STUDY DESIGN.Systematic review with meta-analysis. OBJECTIVE.To assess the relative merits of minimally invasive unilateral laminectomy for bilateral…”
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Metabolic analysis as a driver for discovery, diagnosis, and therapy by DeBerardinis, Ralph J., Keshari, Kayvan R.

“…Metabolic anomalies contribute to tissue dysfunction. Current metabolism research spans from organelles to populations, and new technologies can accommodate…”
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We need to talk about the Warburg effect by DeBerardinis, Ralph J., Chandel, Navdeep S.

“…We are approaching the 100th anniversary of Otto Warburg’s first description of the metabolic phenotype bearing his name—a propensity for tumours to metabolize…”
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The Proto-oncometabolite Fumarate Binds Glutathione to Amplify ROS-Dependent Signaling by Sullivan, Lucas B., Martinez-Garcia, Eva, Nguyen, Hien, Mullen, Andrew R., Dufour, Eric, Sudarshan, Sunil, Licht, Jonathan D., Deberardinis, Ralph J., Chandel, Navdeep S.

“…The tricarboxylic acid cycle enzyme fumarate hydratase (FH) has been identified as a tumor suppressor in a subset of human renal cell carcinomas. Human…”
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Glutamine Oxidation Maintains the TCA Cycle and Cell Survival during Impaired Mitochondrial Pyruvate Transport by Yang, Chendong, Ko, Bookyung, Hensley, Christopher T., Jiang, Lei, Wasti, Ajla T., Kim, Jiyeon, Sudderth, Jessica, Calvaruso, Maria Antonietta, Lumata, Lloyd, Mitsche, Matthew, Rutter, Jared, Merritt, Matthew E., DeBerardinis, Ralph J.

“…Alternative modes of metabolism enable cells to resist metabolic stress. Inhibiting these compensatory pathways may produce synthetic lethality. We previously…”
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Fast near-whole-brain imaging in adult Drosophila during responses to stimuli and behavior by Aimon, Sophie, Katsuki, Takeo, Jia, Tongqiu, Grosenick, Logan, Broxton, Michael, Deisseroth, Karl, Sejnowski, Terrence J, Greenspan, Ralph J

“…Whole-brain recordings give us a global perspective of the brain in action. In this study, we describe a method using light field microscopy to record…”
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The Brain Activity Map Project and the Challenge of Functional Connectomics by Alivisatos, A. Paul, Chun, Miyoung, Church, George M., Greenspan, Ralph J., Roukes, Michael L., Yuste, Rafael

“…The function of neural circuits is an emergent property that arises from the coordinated activity of large numbers of neurons. To capture this, we propose…”
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Mechanical regulation of glycolysis via cytoskeleton architecture by Park, Jin Suk, Burckhardt, Christoph J., Lazcano, Rossana, Solis, Luisa M., Isogai, Tadamoto, Li, Linqing, Chen, Christopher S., Gao, Boning, Minna, John D., Bachoo, Robert, DeBerardinis, Ralph J., Danuser, Gaudenz

“…The mechanics of the cellular microenvironment continuously modulates cell functions such as growth, survival, apoptosis, differentiation and morphogenesis via…”
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Save the planet with green industries using algae by Ralph, Peter J, Pernice, Mathieu

“…We can use photosynthesis to capture carbon and make industries greener. Algae-driven carbon capture and manufacturing offer the potential for reducing CO2…”
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