Search Results - "Rallis, Charalampos"

Transient structural variations have strong effects on quantitative traits and reproductive isolation in fission yeast by Jeffares, Daniel C., Jolly, Clemency, Hoti, Mimoza, Speed, Doug, Shaw, Liam, Rallis, Charalampos, Balloux, Francois, Dessimoz, Christophe, Bähler, Jürg, Sedlazeck, Fritz J.

“…Large structural variations (SVs) within genomes are more challenging to identify than smaller genetic variants but may substantially contribute to phenotypic…”
Get full text

Genome-wide screens in yeast models towards understanding chronological lifespan regulation by Legon, Luc, Rallis, Charalampos

“…Cellular models such as yeasts are a driving force in biogerontology studies. Their simpler genome, short lifespans and vast genetic and genomics resources…”
Get full text

TORC1 signaling inhibition by rapamycin and caffeine affect lifespan, global gene expression, and cell proliferation of fission yeast by Rallis, Charalampos, Codlin, Sandra, Bähler, Jürg

“…Summary Target of rapamycin complex 1 (TORC1) is implicated in growth control and aging from yeast to humans. Fission yeast is emerging as a popular model…”
Get full text

Ribosomal Biogenesis and Heterogeneity in Development, Disease, and Aging by Islam, Rowshan Ara, Rallis, Charalampos

“…Although reported in the literature, ribosome heterogeneity is a phenomenon whose extent and implications in cell and organismal biology is not fully…”
Get full text

Correction: Islam, R.A.; Rallis, C. Ribosomal Biogenesis and Heterogeneity in Development, Disease, and Aging. Epigenomes 2023, 7, 17 by Islam, Rowshan Ara, Rallis, Charalampos

“…23. Akirtava, C.; May, G.E.; McManus, C.J. False-Positive IRESes from Hoxa9 andOther Genes Resulting from Errors in Mam-malian 5’ UTR Annotations [...]…”
Get full text

The TOR Signaling Pathway in Spatial and Temporal Control of Cell Size and Growth by Gonzalez, Suam, Rallis, Charalampos

“…Cell size is amenable by genetic and environmental factors. The highly conserved nutrient-responsive Target of Rapamycin (TOR) signaling pathway regulates…”
Get full text

Amino Acids Whose Intracellular Levels Change Most During Aging Alter Chronological Life Span of Fission Yeast by Rallis, Charalampos, Mülleder, Michael, Smith, Graeme, Au, Yan Zi, Ralser, Markus, Bähler, Jürg

“…Abstract Amino acid deprivation or supplementation can affect cellular and organismal life span, but we know little about the role of concentration changes in…”
Get full text

Long noncoding RNA repertoire and targeting by nuclear exosome, cytoplasmic exonuclease, and RNAi in fission yeast by Atkinson, Sophie R, Marguerat, Samuel, Bitton, Danny A, Rodríguez-López, Maria, Rallis, Charalampos, Lemay, Jean-François, Cotobal, Cristina, Malecki, Michal, Smialowski, Pawel, Mata, Juan, Korber, Philipp, Bachand, François, Bähler, Jürg

“…Long noncoding RNAs (lncRNAs), which are longer than 200 nucleotides but often unstable, contribute a substantial and diverse portion to pervasive noncoding…”
Get full text

The GATA Transcription Factor Gaf1 Represses tRNAs, Inhibits Growth, and Extends Chronological Lifespan Downstream of Fission Yeast TORC1 by Rodríguez-López, María, Gonzalez, Suam, Hillson, Olivia, Tunnacliffe, Edward, Codlin, Sandra, Tallada, Victor A., Bähler, Jürg, Rallis, Charalampos

“…Target of Rapamycin Complex 1 (TORC1) signaling promotes growth and aging. Inhibition of TORC1 leads to reduced protein translation, which promotes longevity…”
Get full text

Nutrient-Response Pathways in Healthspan and Lifespan Regulation by Dabrowska, Aleksandra, Kumar, Juhi, Rallis, Charalampos

“…Cellular, small invertebrate and vertebrate models are a driving force in biogerontology studies. Using various models, such as yeasts, appropriate tissue…”
Get full text

Functional and regulatory profiling of energy metabolism in fission yeast by Malecki, Michal, Bitton, Danny A, Rodríguez-López, Maria, Rallis, Charalampos, Calavia, Noelia Garcia, Smith, Graeme C, Bähler, Jürg

“…The control of energy metabolism is fundamental for cell growth and function and anomalies in it are implicated in complex diseases and ageing. Metabolism in…”
Get full text

Interplays of AMPK and TOR in Autophagy Regulation in Yeast by Alao, John-Patrick, Legon, Luc, Dabrowska, Aleksandra, Tricolici, Anne-Marie, Kumar, Juhi, Rallis, Charalampos

“…Cells survey their environment and need to balance growth and anabolism with stress programmes and catabolism towards maximum cellular bioenergetics economy…”
Get full text

LaSSO, a strategy for genome-wide mapping of intronic lariats and branch points using RNA-seq by Bitton, Danny A, Rallis, Charalampos, Jeffares, Daniel C, Smith, Graeme C, Chen, Yuan Y C, Codlin, Sandra, Marguerat, Samuel, Bähler, Jürg

“…Both canonical and alternative splicing of RNAs are governed by intronic sequence elements and produce transient lariat structures fastened by branch points…”
Get full text

Uncovering Natural Longevity Alleles from Intercrossed Pools of Aging Fission Yeast Cells by Ellis, David A, Mustonen, Ville, Rodríguez-López, María, Rallis, Charalampos, Malecki, Michał, Jeffares, Daniel C, Bähler, Jürg

“…Quantitative traits often show large variation caused by multiple genetic factors . One such trait is the chronological lifespan of non-dividing yeast cells,…”
Get full text

Crosstalk between the mTOR and DNA Damage Response Pathways in Fission Yeast by Alao, John-Patrick, Legon, Luc, Rallis, Charalampos

“…Cells have developed response systems to constantly monitor environmental changes and accordingly adjust growth, differentiation, and cellular stress programs…”
Get full text

Prospects of Pharmacological Interventions to Organismal Aging by Hillson, Olivia, Gonzalez, Suam, Rallis, Charalampos

“…Intense research in the areas of cellular and organismal aging using diverse laboratory model systems has enriched our knowledge in the processes and the…”
Get full text

Spotsizer: High-throughput quantitative analysis of microbial growth by Bischof, Leanne, Převorovský, Martin, Rallis, Charalampos, Jeffares, Daniel C, Arzhaeva, Yulia, Bähler, Jürg

“…Microbial colony growth can serve as a useful readout in assays for studying complex genetic interactions or the effects of chemical compounds. Although…”
Get full text

Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth by Rallis, Charalampos, López-Maury, Luis, Georgescu, Teodora, Pancaldi, Vera, Bähler, Jürg

“…Target of rapamycin complex 1 (TORC1), which controls growth in response to nutrients, promotes ageing in multiple organisms. The fission yeast…”
Get full text

Integrin-linked kinase is a functional Mn2+-dependent protein kinase that regulates glycogen synthase kinase-3β (GSK-3beta) phosphorylation by Maydan, Mykola, McDonald, Paul C, Sanghera, Jasbinder, Yan, Jun, Rallis, Charalampos, Pinchin, Sheena, Hannigan, Gregory E, Foster, Leonard J, Ish-Horowicz, David, Walsh, Michael P, Dedhar, Shoukat

“…Integrin-linked kinase (ILK) is a highly evolutionarily conserved, multi-domain signaling protein that localizes to focal adhesions, myofilaments and…”
Get full text

Php4 Is a Key Player for Iron Economy in Meiotic and Sporulating Cells by Brault, Ariane, Rallis, Charalampos, Normant, Vincent, Garant, Jean-Michel, Bähler, Jürg, Labbé, Simon

“…Meiosis is essential for sexually reproducing organisms, including the fission yeast Schizosaccharomyces pombe In meiosis, chromosomes replicate once in a…”
Get full text