Search Results - "Rakyan, V."

Assessing DNA methylation in the developing human intestinal epithelium: potential link to inflammatory bowel disease by Kraiczy, J, Nayak, K, Ross, A, Raine, T, Mak, T N, Gasparetto, M, Cario, E, Rakyan, V, Heuschkel, R, Zilbauer, M

“…DNA methylation is one of the major epigenetic mechanisms implicated in regulating cellular development and cell-type-specific gene expression. Here we…”
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Specific tumour-associated methylation in normal human term placenta and first-trimester cytotrophoblasts by Novakovic, B., Rakyan, V., Ng, H.K., Manuelpillai, U., Dewi, C., Wong, N.C., Morley, R., Down, T., Beck, S., Craig, J.M., Saffery, R.

“…Human placentation displays many similarities with tumourigenesis, including rapid cell division, migration and invasion, overlapping gene expression profiles…”
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Metastable epialleles in mammals by Rakyan, Vardhman K, Blewitt, Marnie E, Druker, Riki, Preis, Jost I, Whitelaw, Emma

“…There are some mammalian alleles that display the unusual characteristic of variable expressivity in the absence of genetic heterogeneity. It has recently…”
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The marks, mechanisms and memory of epigenetic states in mammals by Rakyan, V K, Preis, J, Morgan, H D, Whitelaw, E

“…It is well recognized that there is a surprising degree of phenotypic variation among genetically identical individuals, even when the environmental…”
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The methylome: approaches for global DNA methylation profiling by Beck, Stephan, Rakyan, Vardhman K

“…DNA methylation plays a critical role in genome function both in health and disease. Almost 60 years after the discovery of 5-methyl cytosine and ∼25 years…”
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Sites of Differential DNA Methylation between Placenta and Peripheral Blood: Molecular Markers for Noninvasive Prenatal Diagnosis of Aneuploidies by Papageorgiou, Elisavet A, Fiegler, Heike, Rakyan, Vardhman, Beck, Stephan, Hulten, Maj, Lamnissou, Klea, Carter, Nigel P, Patsalis, Philippos C

“…The use of epigenetic differences between maternal whole blood and fetal (placental) DNA is one of the main areas of interest for the development of…”
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Transgenerational inheritance of epigenetic states at the murine Axin(Fu) allele occurs after maternal and paternal transmission by Rakyan, Vardhman K, Chong, Suyinn, Champ, Marnie E, Cuthbert, Peter C, Morgan, Hugh D, Luu, Keith V K, Whitelaw, Emma

“…Phenotypic variation that cannot be explained by genetic or environmental heterogeneity has intrigued geneticists for decades. The molecular basis of this…”
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From genome to epigenome by Murrell, Adele, Rakyan, Vardhman K., Beck, Stephan

“…The success of the human genome sequencing project has created wide-spread interest in exploring the human epigenome in order to elucidate how the genome…”
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DNA methylation profiling of the human major histocompatibility complex: a pilot study for the human epigenome project by Rakyan, Vardhman K, Hildmann, Thomas, Novik, Karen L, Lewin, Jörn, Tost, Jörg, Cox, Antony V, Andrews, T Dan, Howe, Kevin L, Otto, Thomas, Olek, Alexander, Fischer, Judith, Gut, Ivo G, Berlin, Kurt, Beck, Stephan

“…The Human Epigenome Project aims to identify, catalogue, and interpret genome-wide DNA methylation phenomena. Occurring naturally on cytosine bases at…”
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Transgenerational inheritance of epigenetic states at the murine Axin super(Fu) allele occurs after maternal and paternal transmission by Rakyan, V K, Chong, S, Champ, ME, Cuthbert, P C, Morgan, H D, Luu, KVK, Whitelaw, E

“…Phenotypic variation that cannot be explained by genetic or environmental heterogeneity has intrigued geneticists for decades. The molecular basis of this…”
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Extracellular ATP couples to cAMP generation and granulocytic differentiation in human NB4 promyelocytic leukaemia cells by van der Weyden, L, Rakyan, V, Luttrell, B M, Morris, M B, Conigrave, A D

“…Priming of NB4 promyelocytic cells with all-trans retinoic acid, followed by extracellular ATP in the presence of a phosphodiesterase inhibitor, elevated cAMP…”
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