Search Results - "Rakowitz, Dietmar"

Synthesis, induced-fit docking investigations, and in vitro aldose reductase inhibitory activity of non-carboxylic acid containing 2,4-thiazolidinedione derivatives by Maccari, Rosanna, Ottanà, Rosaria, Ciurleo, Rosella, Rakowitz, Dietmar, Matuszczak, Barbara, Laggner, Christian, Langer, Thierry

“…In continuation of our studies, we here report a series of non-carboxylic acid containing 2,4-thiazolidinedione derivatives, analogues of previously…”
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Evaluation of in vitro aldose redutase inhibitory activity of 5-arylidene-2,4-thiazolidinediones by Maccari, Rosanna, Ottanà, Rosaria, Ciurleo, Rosella, Vigorita, Maria Gabriella, Rakowitz, Dietmar, Steindl, Theodora, Langer, Thierry

“…A number of 5-arylidene-2,4-thiazolidinediones containing a hydroxy or a carboxymethoxy group in their 5-benzylidene moiety have been synthesised and evaluated…”
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Structure–activity relationships and molecular modelling of 5-arylidene-2,4-thiazolidinediones active as aldose reductase inhibitors by Maccari, Rosanna, Ottanà, Rosaria, Curinga, Carmela, Vigorita, Maria Gabriella, Rakowitz, Dietmar, Steindl, Theodora, Langer, Thierry

“…[Display omitted] The structure–activity relationships (SARs) of 5-arylidene-2,4-thiazolidinediones active as aldose reductase inhibitors (ARIs) were extended…”
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In vitro aldose reductase inhibitory activity of 5-benzyl-2,4-thiazolidinediones by Rakowitz, Dietmar, Maccari, Rosanna, Ottanà, Rosaria, Vigorita, Maria Gabriella

“…Several 5-benzyl-2,4-thiazolidinediones ( 5– 7) were synthesised and tested as in vitro aldose reductase (ALR2) inhibitors. Most of them, particularly…”
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Discovery of Novel Aldose Reductase Inhibitors Characterized by an Alkoxy-Substituted Phenylacetic Acid Core by Rakowitz, Dietmar, Gmeiner, Andreas, Matuszczak, Barbara

“…In continuation of our effort aimed towards the development of novel aldose reductase inhibitors, several phenylacetic acids bearing an alkoxy substituent in…”
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Synthesis and Aldose Reductase Inhibitory Activities of Novel O-Substituted Hydroxyphenylacetic Acid Derivatives by Rakowitz, Dietmar, Angerer, Helga, Matuszczak, Barbara

“…In continuation of our work aimed towards the preparation of novel aldose reductase inhibitors, several O‐substituted hydroxyphenylacetic acid derivatives were…”
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Synthesis of novel phenylacetic acid derivatives with halogenated benzyl subunit and evaluation as aldose reductase inhibitors by Rakowitz, Dietmar, Gmeiner, Andreas, Schröder, Nicole, Matuszczak, Barbara

“…In the course of our ongoing studies several substituted benzyloxyphenylacetic acids were prepared. Comparison of their aldose reductase inhibition with the…”
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Novel Aldose Reductase Inhibitors Derived from 6-[[(Diphenylmethylene)amino]oxy]hexanoic Acid by Rakowitz, Dietmar, Piccolruaz, Grete, Pirker, Cornelia, Matuszczak, Barbara

“…Starting from the recently identified aldose reductase inhibitor 6‐[[(diphenylmethylene)amino]oxy]hexanoic acid 1, the following systematic structural…”
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On the Synthesis of Bioisosters of O-Benzothiazolyloxybenzoic Acids and Evaluation as Aldose Reductase Inhibitors by Rakowitz, Dietmar, Muigg, Patric, Schröder, Nicole, Matuszczak, Barbara

“…In continuation of our attempts to develop novel aldose reductase inhibitors (ARIs), a number of compounds characterized by bioisosteric replacement of…”
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Synthesis of Novel Benzoic Acid Derivatives with Benzothiazolyl Subunit and Evaluation as Aldose Reductase Inhibitors by Rakowitz, Dietmar, Hennig, Barbara, Nagano, Marietta, Steger, Stefan, Costantino, Luca, Matuszczak, Barbara

“…Several methyl benzothiazolyloxybenzoates, S‐isosters, and the corresponding benzoic acids were synthesized and tested as aldose reductase inhibitors (ARIs)…”
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Diazine-derived guanidines, isothioureas, and isoureas: Synthesis and attempts of configurational assignment by Heinisch, Gottfried, Matuszczak, Barbara, Rakowitz, Dietmar, Mereiter, Kurt

“…The utility of diazinyl substituted carbodiimides (1a‐c) for the synthesis of novel guanidines (2), isothioureas (3), and isoureas (4) is shown. Attempts to…”
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On the prodrug potential of novel aldose reductase inhibitors with diphenylmethyleneaminooxycarboxylic acid structure by Rakowitz, Dietmar, Matuszczak, Barbara, Gritsch, Stefan, Hofbauer, Peter, Krassnigg, Andreas, Costantino, Luca

“…Diphenylmethyleneaminooxycarboxylic acids were found to represent novel type inhibitors of the enzyme aldose reductase. Ester derivatives of the most active…”
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Pyridazines 93. an unexpected reaction behaviour of 3-aminopyridazine towards 2-methylphenylisocyanate by Heinisch, Gottfried, Hetzenauer, Alfred, Matuszczak, Barbara, Rakowitz, Dietmar, Mereiter, Kurt

“…Reaction of 3‐aminopyridazine (1) with 2‐mefhylphenylisocyante (4) affords not only the desired urea derivative (5) but also an unexpected side‐product (6),…”
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Synthesis of N-aryl-N'-heteroaryl-substituted urea and thiourea derivatives and evaluation of their anticonvulsant activity by Heinisch, G, Matuszczak, B, Rakowitz, D, Tantisira, B

“…Starting from amino(di)azines and 2-chloro-6-methyliso(thio)cyanate a series of aryl-substituted urea and thiourea derivatives was prepared and screened as…”
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A series of diarylsubstituted oximes as potential substrate for new aldose reductase inhibitors by Rakowitz, Dietmar, Heinisch, Gottfried, Lukavsky, Peter, Kiendler, Sigrid, Trenkwalder, Cornelia, Barlocco, Daniela, Rastelli, Giulio, Costantino, Luca

“…In the course of our research aimed at the discovery of new compounds acting as aldose reductase inhibitors, we tested a series of some (E)‐ and…”
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Diazine-substituted tert-butylureas and tert-butylthioureas and a convenient access to the related carbodiimides by Heinisch, Gottfried, Matuszczak, Barbara, Pürstinger, Gerhard, Rakowitz, Dietmar

“…An efficient procedure for the preparation of diazine‐substituted urea and thiourea derivatives 3a‐c, 5a‐c is proposed. On attempts to prepare the related…”
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Insight into novel cyclization reactions using acetic anhydride in the presence of 4-dimethylaminopyridine by AICHNER, J, EGG, H, GAPP, D, HALLER, S, RAKOWITZ, D, RAMSPACHER, U

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