Search Results - "Rake, James B."

Mammalian topoisomerase II inhibitory activity of 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarboxylic acid and related derivatives by Wentland, Mark P, Lesher, George Y, Reuman, Michael, Gruett, Monte D, Singh, Baldev, Aldous, Suzanne C, Dorff, Peter H, Rake, James B, Coughlin, Susan A

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Synthesis and bacterial DNA gyrase inhibitory properties of a spirocyclopropylquinolone derivative by Wentland, Mark P, Perni, Robert B, Dorff, Peter H, Rake, James B

“…A novel conformationally restricted 1-cyclopropylquinolone (1) that incorporates structural features of both ofloxacin and ciprofloxacin has been prepared…”
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Synthesis and Antitumor Activity of 4-Aminomethylthioxanthenone and 5-Aminomethylbenzothiopyranoindazole Derivatives by Perni, Robert B, Wentland, Mark P, Huang, Jianhua I, Powles, Ronald G, Aldous, Suzanne, Klingbeil, Kristina M, Peverly, A. Danielle, Robinson, Ronald G, Corbett, Thomas H, Jones, Julie L, Mattes, Kenneth C, Rake, James B, Coughlin, Susan A

“…Two new series of antitumor agents, 4-aminomethylthioxanthenones (6 − 50) and 5-aminomethylbenzothiopyranoindazoles (51 − 61), are described and compared…”
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Synthesis and Antibacterial Activity of Some Novel 1-Substituted 1,4-Dihydro-4-oxo-7-pyridinyl-3-quinolinecarboxylic Acids. Potent Antistaphylococcal Agents by Reuman, Michael, Daum, Sol J, Singh, Baldev, Wentland, Mark P, Perni, Robert B, Pennock, Patrick, Carabateas, Philip M, Gruett, Monte D, Saindane, Manohar T, Dorff, Peter H, Coughlin, Susan A, Sedlock, David M, Rake, James B, Lesher, George Y

“…The palladium-catalyzed coupling of 3- and 4-(trialkylstannyl)pyridines with 7-bromo or 7-chloro 1-substituted 1,4-dihydro-4-oxo-3-quinolinecarboxylates has…”
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Effects of SW 33377, SW 68210 and SW 71425 thioxanthones on in vitro colony formation of freshly explanted human tumor cells by IZBICKA, E, LAWRENCE, R, DAVIDSON, K, RAKE, J. B, VON HOFF, D. D

“…Thioxanthones are aromatic hydrocarbons with cytotoxic activity against several tumor models. Potential mechanisms of action may include DNA intercalation,…”
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Parvodicin, a novel glycopeptide from a new species, Actinomadura parvosata: discovery, taxonomy, activity and structure elucidation by Christensen, S B, Allaudeen, H S, Burke, M R, Carr, S A, Chung, S K, DePhillips, P, Dingerdissen, J J, DiPaolo, M, Giovenella, A J, Heald, S L

“…An extensive taxonomic investigation identified strain SK&F-AAJ-271 as a new species, designated Actinomadura parvosata. Fermentations of this organism produce…”
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Affinity of cefonicid, a long-acting cephalosporin, for the penicillin-binding proteins of Escherichia coli K-12 by Rake, J B, Newman, D J, Actor, P

“…The binding of cefonicid (SK&F 75073), a new parenteral cephalosporin, to the penicillin-binding proteins (PBPs) of Escherichia coli K-12 (strain KN-126) was…”
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Mechanism of action and antitumor activity of (S)-10-(2,6-dimethyl-4-pyridinyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyridol[1,2,3-de]-[1,4]benzothiazine-6-carboxylic acid (WIN 58161) by COUGHLIN, S. A, DANZ, D. W, RAKE, J. B, ROBINSON, R. G, KLINGBEIL, K. M, WENTLAND, M. P, CORBETT, T. H, WAUD, W. R, ZWELLING, L. A, ALTSCHULER, E, BALES, E

“…(S)-10-(2,6-Dimethyl-4-pyridinyl) 9-fluoro-3-methyl-7-oxo 2,3-dihydro-7H-pyrido[1,2,3-de] [1,4]benzothiazine-6-carboxylic acid (WIN 58161) is an…”
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Neurotensin receptor-mediated inhibition of pancreatic cancer cell growth by the neurotensin antagonist SR 48692 by Herzig, M C, Chapman, W G, Sheridan, A, Rake, J B, Woynarowski, J M

“…Second messenger calcium responses to the neuropeptide neurotensin and its non-peptide antagonist SR 48692 were studied in relation to the proliferation of…”
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The antitumor activity of novel pyrazoloquinoline derivatives by Wentland, Mark P., Aldous, Suzanne C., Gruett, Monte D., Perni, Robert B., Powles, Ronald G., Danz, Deborah W., Klingbeil, Kristina M., Peverly, A.Danielle, Robinson, Ronald G., Corbett, Thomas H., Rake, James B., Coughlin, Susan A.

“…Mammalian topoisomerase II inhibition activity has been identified in a series of novel pyrazoloquinoline derivatives; potency for two analogues containing…”
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Cyclic variations of SR 233377 (WIN 33377) and effects on antitumor activity by Wentland, Mark P., Perni, Robert B., Huang, Jianhua I., Powles, Ronald G., Aldous, Suzanne C., Klingbeil, Kristina M., Danielle Peverly, A., Robinson, Ronald G., Corbett, Thomas H., Jones, Julie L., Rake, James B., Coughlin, Susan A.

“…Novel derivatives of SR 233377 ( 1, WIN 33377) where a pyrazolo ring fusion has been incorporated at the 1- and 9-positions of the thioxanthone ring displayed…”
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Inhibition of platelet-derived growth factor-mediated signal transduction by transforming ras. Suppression of receptor autophosphorylation by Rake, J B, Quiñones, M A, Faller, D V

“…The function of ras protein and its relationship to growth-factor mediated signal transduction remain unclear. The demonstration that the expression of…”
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Dissociation of platelet-derived growth factor (PDGF) receptor autophosphorylation from other PDGF-mediated second messenger events by QUINONES, M. A, MUNDSCHAU, L. J, RAKE, J. B, FALLER, D. V

“…Activated p21ras alters the platelet-derived growth factor (PDGF) signal transduction pathway in fibroblasts by inhibiting autophosphorylation of the receptor…”
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Mechanism of action and antitumor activity of ( S)-10-(2,6-dimethyl-4-pyridinyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7 H-pyridol [1,2,3- de]-[1,4]benzothiazine-6-carboxylic acid (WIN 58161) by Coughlin, Susan A., Danz, Deborah W., Robinson, Ronald G., Klingbeil, Kristina M., Wentland, Mark P., Corbett, Thomas H., Waud, William R., Zwelling, Leonard A., Altschuler, Elizabeth, Bales, Elise, Rake, James B.

“…( S)-10-(2,6-Dimethyl-4-pyridinyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7 H-pyrido[1,2,3 de][1,4] benzothiazine-6-carboxylic acid (WIN 58161) is an…”
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