Search Results - "Rak, Roni"
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Repertoires of tRNAs: The Couplers of Genomics and Proteomics
Published in Annual review of cell and developmental biology (06-10-2018)“…The pool of transfer RNA (tRNA) molecules in cells allows the ribosome to decode genetic information. This repertoire of molecular decoders is positioned in…”
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Systematic Detection of Amino Acid Substitutions in Proteomes Reveals Mechanistic Basis of Ribosome Errors and Selection for Translation Fidelity
Published in Molecular cell (08-08-2019)“…The translation machinery and the genes it decodes co-evolved to achieve production throughput and accuracy. Nonetheless, translation errors are frequent, and…”
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Manipulation of the human tRNA pool reveals distinct tRNA sets that act in cellular proliferation or cell cycle arrest
Published in eLife (24-12-2020)“…Different subsets of the tRNA pool in human cells are expressed in different cellular conditions. The 'proliferation-tRNAs' are induced upon normal and…”
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Tissue- and Time-Specific Expression of Otherwise Identical tRNA Genes
Published in PLoS genetics (25-08-2016)“…Codon usage bias affects protein translation because tRNAs that recognize synonymous codons differ in their abundance. Although the current dogma states that…”
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Challenges and opportunities in cell expansion for cultivated meat
Published in Frontiers in nutrition (Lausanne) (07-02-2024)“…The cultivation of meat using grown animal stem cells offers a promising solution to pressing global concerns around climate change, ethical considerations,…”
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Evolthon: A community endeavor to evolve lab evolution
Published in PLoS biology (29-03-2019)“…In experimental evolution, scientists evolve organisms in the lab, typically by challenging them to new environmental conditions. How best to evolve a desired…”
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Probiotic cultivated meat: bacterial-based scaffolds and products to improve cultivated meat
Published in Trends in biotechnology (Regular ed.) (01-03-2024)“…Cultured meat production requires microcarriers, hydrogels, and scaffolds for 3D growth and support.Co-culturing techniques of probiotic bacteria and cell…”
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Targeting LIM kinase in cancer and neurofibromatosis
Published in Cell cycle (Georgetown, Tex.) (01-05-2014)Get full text
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Dynamic changes in tRNA modifications and abundance during T cell activation
Published in Proceedings of the National Academy of Sciences - PNAS (19-10-2021)“…The tRNA pool determines the efficiency, throughput, and accuracy of translation. Previous studies have identified dynamic changes in the tRNA (transfer RNA)…”
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Computer-based identification of a novel LIMK1/2 inhibitor that synergizes with salirasib to destabilize the actin cytoskeleton
Published in Oncotarget (01-06-2012)“…Neurofibromin regulates cell motility via three distinct GTPase pathways acting through two different domains, the Ras GTPase-activating protein-related domain…”
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Novel LIMK2 Inhibitor Blocks Panc-1 Tumor Growth in a mouse xenograft model
Published in Oncoscience (2014)“…LIM kinases (LIMKs) are important cell cytoskeleton regulators that play a prominent role in cancer manifestation and neuronal diseases. The LIMK family…”
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