Search Results - "Raju, V S"

Nanoparticle-Assisted Targeted Delivery of Eye-Specific Genes to Eyes Significantly Improves the Vision of Blind Mice In Vivo by Rajala, Ammaji, Wang, Yuhong, Zhu, Ye, Ranjo-Bishop, Michelle, Ma, Jian-Xing, Mao, Chuanbin, Rajala, Raju V. S

“…Application of viruses as a carrier, though not safe, to deliver genes to eye tissue was successful. However, a safer, nonviral, biocompatible lipid-based…”
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Age-Related Changes in the Glycolytic Enzymes of M2-Isoform of Pyruvate Kinase and Fructose-1,6-Bisphosphate Aldolase: Implications to Age-Related Macular Degeneration by Rajala, Ammaji, Rajala, Raju V S

“…Prior studies have emphasized a bioenergetic crisis in the retinal pigment epithelium (RPE) as a critical factor in the development of age-related macular…”
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Aerobic Glycolysis in the Retina: Functional Roles of Pyruvate Kinase Isoforms by Rajala, Raju V S

“…One hundred years ago, Otto Heinrich Warburg observed that postmitotic retinal cells are the highest oxygen-consuming cells in the body. He compared these…”
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Age-related retinal degeneration resulting from the deletion of Shp2 tyrosine phosphatase in photoreceptor neurons by Rajala, Ammaji, Rajala, Rahul, Bhat, Mohd A., Eminhizer, Mark, Hao, Jeff, Du, Jianhai, Rajala, Raju V. S.

“…Shp2, a critical SH2-domain-containing tyrosine phosphatase, is essential for cellular regulation and implicated in metabolic disruptions, obesity, diabetes,…”
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Insulin-like growth factor 1 receptor mediates photoreceptor neuroprotection by Rajala, Ammaji, Teel, Kenneth, Bhat, Mohd A., Batushansky, Albert, Griffin, Timothy M., Purcell, Lindsey, Rajala, Raju V. S.

“…Insulin-like growth factor I (IGF-1) is a neurotrophic factor and is the ligand for insulin-like growth factor 1 receptor (IGF-1R). Reduced expression of IGF-1…”
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Pathogenic Role of microRNA-21 in Diabetic Retinopathy Through Downregulation of PPARα by Chen, Qian, Qiu, Fangfang, Zhou, Kelu, Matlock, H Greg, Takahashi, Yusuke, Rajala, Raju V S, Yang, Yanhui, Moran, Elizabeth, Ma, Jian-Xing

“…Fenofibrate, a specific agonist of peroxisome proliferator-activated receptor-α (PPARα), displays robust therapeutic effects on diabetic retinopathy (DR) in…”
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MicroRNA-184 modulates canonical Wnt signaling through the regulation of frizzled-7 expression in the retina with ischemia-induced neovascularization by Takahashi, Yusuke, Chen, Qian, Rajala, Raju V.S., Ma, Jian-xing

“…•MiR-184 is down-regulated in the retina of OIR mice.•Canonical Wnt signaling is regulated by miR-184.•Fzd7 is a downstream target of miR-184.•Delivery of…”
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Unlocking the role of lactate: metabolic pathways, signaling, and gene regulation in postmitotic retinal cells by Rajala, Raju V S, Rajala, Ammaji

“…The Warburg effect, which was first described a century ago, asserts that mitotic tumor cells generate higher quantities of lactate. Intriguingly, even in…”
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Loss of Neuroprotective Survival Signal in Mice Lacking Insulin Receptor Gene in Rod Photoreceptor Cells by Rajala, Ammaji, Tanito, Masaki, Le, Yun Z., Kahn, C. Ronald, Rajala, Raju V.S.

“…Insulin receptor (IR) signaling provides a trophic signal for transformed retinal neurons in culture, but the role of IR activity in vivo is unknown. We…”
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Pyruvate kinase M2 regulates photoreceptor structure, function, and viability by Rajala, Ammaji, Wang, Yuhong, Brush, Richard S., Tsantilas, Kristine, Jankowski, Connor S. R., Lindsay, Ken J., Linton, Jonathan D., Hurley, James B., Anderson, Robert E., Rajala, Raju V. S.

“…Pyruvate kinase M2 (PKM2) is a glycolytic enzyme that is expressed in cancer cells. Its role in tumor metabolism is not definitively established, but…”
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Lipid Nanoparticles for Ocular Gene Delivery by Wang, Yuhong, Rajala, Ammaji, Rajala, Raju V S

“…Lipids contain hydrocarbons and are the building blocks of cells. Lipids can naturally form themselves into nano-films and nano-structures, micelles, reverse…”
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HDPE-Fly Ash/Nano Fly Ash Composites by Satapathy, Sukanya, Nando, Golok Bihari, Nag, Ahin, Raju, K. V. S. N.

“…ABSTRACT Fly ash (FA) based polymer composites are assuming increasing importance because of its potentiality, fine particle size and plenty availability of…”
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Large area strain analysis using scanning transmission electron microscopy across multiple images by Oni, A. A., Sang, X., Raju, S. V., Dumpala, S., Broderick, S., Kumar, A., Sinnott, S., Saxena, S., Rajan, K., LeBeau, J. M.

“…Here, we apply revolving scanning transmission electron microscopy to measure lattice strain across a sample using a single reference area. To do so, we remove…”
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Characterization of Anthocyanins and Their Antioxidant Activities in Indian Rose Varieties (Rosa × hybrida) Using HPLC by Kumari, Poonam, Raju, D. V. S., Prasad, K. V., Saha, Supradip, Panwar, Sapna, Paul, Surinder, Banyal, Namita, Bains, Aarti, Chawla, Prince, Fogarasi, Melinda, Fogarasi, Szabolcs

“…The present study was designed to explore the anthocyanin profile and antioxidant activities in Indian rose varieties (Rosa × hybrida). Among fifty varieties,…”
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Retraction Note: Impact of daily high dose oral vitamin D therapy on the inflammatory markers in patients with COVID 19 disease by Lakkireddy, Maheshwar, Gadiga, Srikanth Goud, Malathi, R. D., Karra, Madhu Latha, Raju, I. S. S. V. Prasad Murthy, Ragini, Chinapaka, Sangeetha, Baba, K. S. S. Sai, Kandakatla, Manohar

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Optimization of physical schemes in WRF model on cyclone simulations over Bay of Bengal using one-way ANOVA and Tukey’s test by Shenoy, Meenakshi, Raju, P. V. S., Prasad, Jagdish

“…Evaluation of appropriate physics parameterization schemes for the Weather Research and Forecasting (WRF) model is vital for accurately forecasting tropical…”
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Influence of fly ash cenospheres on performance of coir fiber-reinforced recycled high-density polyethylene biocomposites by Satapathy, Sukanya, Kothapalli, Raju V. S.

“…ABSTRACT Recycled high‐density polyethylene (RHDPE)/coir fiber (CF)‐reinforced biocomposites were fabricated using melt blending technique in a twin‐screw…”
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A non‐canonical rhodopsin‐mediated insulin receptor signaling pathway in retinal photoreceptor neurons by Rajala, Ammaji, Rajala, Raju V.S.

“…We previously reported a ligand‐independent and rhodopsin‐dependent insulin receptor (IR) neuroprotective signaling pathway in both rod and cone photoreceptor…”
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Impaired Association of Retinal Degeneration-3 with Guanylate Cyclase-1 and Guanylate Cyclase-activating Protein-1 Leads to Leber Congenital Amaurosis-1 by Zulliger, Rahel, Naash, Muna I., Rajala, Raju V.S., Molday, Robert S., Azadi, Seifollah

“…One-fifth of all cases of Leber congenital amaurosis are type 1 (LCA1). LCA1 is a severe form of retinal dystrophy caused by loss-of-function mutations in…”
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Diabetes Reduces Autophosphorylation of Retinal Insulin Receptor and Increases Protein-Tyrosine Phosphatase-1B Activity by Rajala, Raju V. S, Wiskur, Brandt, Tanito, Masaki, Callegan, Michelle, Rajala, Ammaji

“…Protein-tyrosine phosphatase-1B (PTP1B) has been implicated in the negative regulation of insulin signaling. The expression, activity, and functional role of…”
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