Search Results - "Raju, Kanumuri S"

Antileishmanial Activity of Pyrazolopyridine Derivatives and Their Potential as an Adjunct Therapy with Miltefosine by Anand, Devireddy, Yadav, Pawan Kumar, Patel, Om P. S, Parmar, Naveen, Maurya, Rahul K, Vishwakarma, Preeti, Raju, Kanumuri S. R, Taneja, Isha, Wahajuddin, M, Kar, Susanta, Yadav, Prem P

“…A series of pyrazolo­(dihydro)­pyridines was synthesized and evaluated for antileishmanial efficacy against experimental visceral leishmaniasis (VL). Among all…”
Get full text

Naturally Occurring Carbazole Alkaloids from Murraya koenigii as Potential Antidiabetic Agents by Patel, Om P. S, Mishra, Akansha, Maurya, Ranjani, Saini, Deepika, Pandey, Jyotsana, Taneja, Isha, Raju, Kanumuri S. R, Kanojiya, Sanjeev, Shukla, Sanjeev K, Srivastava, Mahendra N, Wahajuddin, M, Tamrakar, Akhilesh K, Srivastava, Arvind K, Yadav, Prem P

“…This study identified koenidine (4) as a metabolically stable antidiabetic compound, when evaluated in a rodent type 2 model (leptin receptor-deficient db/db…”
Get full text

Investigation of the Functional Role of P-Glycoprotein in Limiting the Oral Bioavailability of Lumefantrine by WAHAJUDDIN, RAJU, Kanumuri S. R, SINGH, Sheelendra P, TANEJA, Isha

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Intravenous pharmacokinetics, oral bioavailability, dose proportionality and in situ permeability of anti-malarial lumefantrine in rats by Wahajuddin, Singh, Sheelendra P, Raju, Kanumuri S R, Nafis, Asad, Puri, Sunil K, Jain, Girish K

“…Despite the wide spread use of lumefantrine, there is no study reporting the detailed preclinical pharmacokinetics of lumefantrine. For the development of…”
Get full text

Synthesis and Antimalarial Activity of 3,3-Spiroanellated 5,6-Disubstituted 1,2,4-Trioxanes by Maurya, Ranjani, Soni, Awakash, Anand, Devireddy, Ravi, Makthala, Raju, Kanumuri S. R, Taneja, Isha, Naikade, Niraj K, Puri, S. K, Wahajuddin, Kanojiya, Sanjeev, Yadav, Prem P

“…Novel 3,3-spiroanellated 5-aryl, 6-arylvinyl-substituted 1,2,4-trioxanes 19–34 have been synthesized and appraised for their antimalarial activity against…”
Get full text

Oral IRAK-4 Inhibitor CA-4948 Is Blood-Brain Barrier Penetrant and Has Single-Agent Activity against CNS Lymphoma and Melanoma Brain Metastases by Von Roemeling, Christina A, Doonan, Bently P, Klippel, Kelena, Schultz, Daniel, Hoang-Minh, Lan, Trivedi, Vrunda, Li, Chenglong, Russell, Rylynn A, Kanumuri, Raju S, Sharma, Abhisheak, Tun, Han W, Mitchell, Duane A

“…An ongoing challenge in cancer is the management of primary and metastatic brain malignancies. This is partly due to restrictions of the blood-brain barrier…”
Get full text

The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study by Berthold, Erin C, Kamble, Shyam H, Raju, Kanumuri S, Kuntz, Michelle A, Senetra, Alexandria S, Mottinelli, Marco, León, Francisco, Restrepo, Luis F, Patel, Avi, Ho, Nicholas P, Hiranita, Takato, Sharma, Abhisheak, McMahon, Lance R, McCurdy, Christopher R

“…Kratom ( ), a Southeast Asian tree, has been used for centuries in pain relief and mitigation of opium withdrawal symptoms. Mitragynine (MTG), the major kratom…”
Get full text

Elucidation of plasma protein binding, blood partitioning, permeability, CYP phenotyping and CYP inhibition studies of Withanone using validated UPLC method: An active constituent of neuroprotective herb Ashwagandha by Singh, Sandeep K., Valicherla, Guru R., Bikkasani, Anil K., Cheruvu, Srikanth H., Hossain, Zakir, Taneja, Isha, Ahmad, Hafsa, Raju, Kanumuri S.R., Sangwan, Neelam S., Singh, Shio K., Dwivedi, Anil K., Wahajuddin, Mohammad, Gayen, Jiaur R.

“…Withanone (WN), an active constituent of Withania somnifera commonly called Ashwagandha has remarkable pharmacological responses along with neurological…”
Get full text

UPLC-MS/MS method for the quantification of MCI-77, a novel sigma-1 receptor ligand, and its application to pharmacokinetic studies by Popa, Raluca, Kamble, Shyam H., Kanumuri, Raju S., King, Tamara I., Berthold, Erin C., Intagliata, Sebastiano, Sharma, Abhisheak, McCurdy, Christopher R.

“…•An UPLC-MS/MS method was developed to quantify the novel compound MCI-77.•The method was validated in accordance with FDA guidelines.•The method was used to…”
Get full text

Preclinical pharmacokinetic study of speciociliatine, a kratom alkaloid, in rats using an UPLC-MS/MS method by Berthold, Erin C., Kamble, Shyam H., Raju, Kanumuri S., King, Tamara I., Popa, Raluca, Sharma, Abhisheak, León, Francisco, Avery, Bonnie A., McMahon, Lance R., McCurdy, Christopher R.

“…•Kratom is a Southeast Asian plant used in the United States for pain relief and mitigation of opioid withdrawal symptoms.•Speciociliatine in a minor indole…”
Get full text

Bioanalytical method development and pharmacokinetics of MCI-92, a sigma-1 receptor ligand by Popa, Raluca, Kamble, Shyam H., Kanumuri, Raju S., King, Tamara I., Berthold, Erin C., Intagliata, Sebastiano, Sharma, Abhisheak, McCurdy, Christopher R.

“…•A UPLC-MS/MS bioanalytical method for the quantification of MCI-92 was developed.•The method was validated in mouse plasma and brain following FDA…”
Get full text

Simultaneous quantification of proposed anti-malarial combination comprising of lumefantrine and CDRI 97-78 in rat plasma using the HPLC-ESI-MS/MS method: application to drug interaction study by Wahajuddin, Muhammad, Singh, Sheelendra P, Taneja, Isha, Raju, Kanumuri S R, Gayen, Jiaur R, Siddiqui, Hefazat H, Singh, Shio K

“…Lumefantrine is the mainstay of anti-malarial combination therapy in most endemic countries presently. However, it cannot be used alone owing to its long onset…”
Get full text

A novel nanosized phospholipid complex of Biochanin A for improving oral bioavailability: Preparation and in-vitro/in-vivo characterizations by Singh, Sandeep Kumar, Rashid, Mamunur, Bhalala, Kripal, Malik, Yaseen, Chaturvedi, Swati, Raju, Kanumuri S.R., Sultana, Nazneen, Mitra, Kalyan, Gayen, Jiaur R., Wahajuddin, Muhammad

“…Biochanin A (BCA) is a natural methoxylated-isoflavone and has been stated to have various therapeutic potentials. However, poor aqueous solubility and low…”
Get full text