Search Results - "Raju, Diana N."

Cyclic Nucleotide-Specific Optogenetics Highlights Compartmentalization of the Sperm Flagellum into cAMP Microdomains by Raju, Diana N, Hansen, Jan N, Rassmann, Sebastian, Stüven, Birthe, Jikeli, Jan F, Strünker, Timo, Körschen, Heinz G, Möglich, Andreas, Wachten, Dagmar

“…Inside the female genital tract, mammalian sperm undergo a maturation process called capacitation, which primes the sperm to navigate across the oviduct and…”
Get full text

Species-specific differences in nonlysosomal glucosylceramidase GBA2 function underlie locomotor dysfunction arising from loss-of-function mutations by Woeste, Marina A., Stern, Sina, Raju, Diana N., Grahn, Elena, Dittmann, Dominik, Gutbrod, Katharina, Dörmann, Peter, Hansen, Jan N., Schonauer, Sophie, Marx, Carina E., Hamzeh, Hussein, Körschen, Heinz G., Aerts, Johannes M.F.G., Bönigk, Wolfgang, Endepols, Heike, Sandhoff, Roger, Geyer, Matthias, Berger, Thomas K., Bradke, Frank, Wachten, Dagmar

“…The nonlysosomal glucosylceramidase β2 (GBA2) catalyzes the hydrolysis of glucosylceramide to glucose and ceramide. Mutations in the human GBA2 gene have been…”
Get full text

Identification of a feedback loop involving β-glucosidase 2 and its product sphingosine sheds light on the molecular mechanisms in Gaucher disease by Schonauer, Sophie, Körschen, Heinz G., Penno, Anke, Rennhack, Andreas, Breiden, Bernadette, Sandhoff, Konrad, Gutbrod, Katharina, Dörmann, Peter, Raju, Diana N., Haberkant, Per, Gerl, Mathias J., Brügger, Britta, Zigdon, Hila, Vardi, Ayelet, Futerman, Anthony H., Thiele, Christoph, Wachten, Dagmar

“…The lysosomal acid β-glucosidase GBA1 and the non-lysosomal β-glucosidase GBA2 degrade glucosylceramide (GlcCer) to glucose and ceramide in different cellular…”
Get full text