A network map of GDNF/RET signaling pathway in physiological and pathological conditions

A network map of GDNF/RET signaling pathway in physiological and pathological conditions

Glial cell line-derived neurotrophic factor (GDNF) signals through a multi-component receptor system predominantly consisting of glycosyl-phosphatidylinositol-anchored GDNF family receptor alpha-1 (GFRα1) and the Rearranged during transfection (RET) receptor tyrosine kinase. GDNF/RET signaling is vi...

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Bibliographic Details
Published in:Journal of cell communication and signaling Vol. 17; no. 3; pp. 1089 - 1095
Main Authors: Mol, Praseeda, Balaya, Rex Devasahayam Arokia, Dagamajalu, Shobha, Babu, Sreeranjini, Chandrasekaran, Pavithra, Raghavan, Reshma, Suresh, Sneha, Ravishankara, Namitha, Raju, Anu Hemalatha, Nair, Bipin, Modi, Prashant Kumar, Mahadevan, Anita, Prasad, Thottethodi Subrahmanya Keshava, Raju, Rajesh
Format: Journal Article
Language:English
Published: Dordrecht Springer Netherlands 01-09-2023
John Wiley & Sons, Inc
Subjects:
Biomedical and Life Sciences
Biomedicine
Catalysis
Cell Biology
Gene regulation
Glial cell line-derived neurotrophic factor
Glial cells
Glycosylphosphatidylinositol
Kinases
Life Sciences
Morphogenesis
Multi‐component receptor system
Nervous system
Neuronal-glial interactions
Neurotrophic factors
Nuts and Bolts
Phosphatidylinositol
Post‐translational modifications
Protein-tyrosine kinase receptors
Protein–protein interactions
Receptor tyrosine kinases
Ret protein
Signal transduction
Signaling network
Spermatogenesis
Transfection
Multi-component receptor system
Protein–protein interactions
Post-translational modifications
Signaling network
Receptor tyrosine kinases
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Description
Summary:Glial cell line-derived neurotrophic factor (GDNF) signals through a multi-component receptor system predominantly consisting of glycosyl-phosphatidylinositol-anchored GDNF family receptor alpha-1 (GFRα1) and the Rearranged during transfection (RET) receptor tyrosine kinase. GDNF/RET signaling is vital to the central and peripheral nervous system, kidney morphogenesis, and spermatogenesis. In addition, the dysregulation of the GDNF/RET signaling has been implicated in the pathogenesis of cancers. Despite the extensive research on GDNF/RET signaling, a molecular network of reactions induced by GDNF reported across the published literature. However, a comprehensive GDNF/RET pathway resource is currently unavailable. We describe an integrated signaling pathway reaction map of GDNF/RET consisting of 1151 molecular reactions. These include information pertaining to 52 molecular association events, 70 enzyme catalysis events, 36 activation/inhibition events, 22 translocation events, 856 gene regulation events, and 115 protein-level expression events induced by GDNF in diverse cell types. We developed a comprehensive GDNF/RET signaling network map based on these molecular reactions. The pathway map was made accessible through WikiPathways database ( https://www.wikipathways.org/index.php/Pathway:WP5143 ). Graphical abstract Biocuration and development of gene regulatory network map of GDNF/RET signaling pathway
Bibliography:The online version contains supplementary material available at
Supplementary Information
https://doi.org/10.1007/s12079‐023‐00726‐1
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ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1873-9601
1873-961X
DOI:10.1007/s12079-023-00726-1