Search Results - "Rajpurkar, Aparna"
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Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development
Published in Nature (London) (01-07-2018)“…The thymus is responsible for generating a diverse yet self-tolerant pool of T cells 1 . Although the thymic medulla consists mostly of developing and mature…”
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Journal Article -
2
Deep learning connects DNA traces to transcription to reveal predictive features beyond enhancer–promoter contact
Published in Nature communications (08-06-2021)“…Chromatin architecture plays an important role in gene regulation. Recent advances in super-resolution microscopy have made it possible to measure chromatin 3D…”
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Journal Article -
3
Prevalent, Dynamic, and Conserved R-Loop Structures Associate with Specific Epigenomic Signatures in Mammals
Published in Molecular cell (07-07-2016)“…R-loops are three-stranded nucleic acid structures formed upon annealing of an RNA strand to one strand of duplex DNA. We profiled R-loops using a…”
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Journal Article -
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Beyond Enhancer-Promoter Contact: Leveraging Deep Learning to Connect Super-Resolution DNA Traces to Transcription
Published 01-01-2021“…Chromatin architecture plays an important role in gene regulation. Recent advances in super-resolution microscopy have made it possible to measure chromatin 3D…”
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Dissertation -
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Thymic tuft cells promote an IL4-enriched medulla and shape thymocyte development
Published in Nature (London) (01-07-2018)“…The thymus is responsible for generating a diverse yet self-tolerant T cell pool 1 . While the thymic medulla is largely composed of developing and mature AIRE…”
Get full text
Journal Article