Search Results - "Rajpal, K"

Paclitaxel-Eluting versus Everolimus-Eluting Coronary Stents in Diabetes by Kaul, Upendra, Bangalore, Sripal, Seth, Ashok, Arambam, Priyadarshini, Abhaychand, Rajpal K, Patel, Tejas M, Banker, Darshan, Abhyankar, Atul, Mullasari, Ajit S, Shah, Sanjay, Jain, Rajneesh, Kumar, Premchand R, Bahuleyan, C.G

“…In this trial, 1830 patients undergoing PCI were assigned to receive a paclitaxel-eluting or an everolimus-eluting stent. At 1 year, rates of target-vessel…”
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Applications of Connectivity Map in drug discovery and development by Qu, Xiaoyan A., Rajpal, Deepak K.

“…► CMap approach offers alternative ways to drug discovery. ► CMap enables efficient hypothesis generation for mechanism understanding and drug repurposing. ►…”
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United States Multicenter Clinical Trial of Corneal Collagen Crosslinking for Keratoconus Treatment by Hersh, Peter S., MD, Stulting, R. Doyle, MD, PhD, Muller, David, PhD, Durrie, Daniel S., MD, Rajpal, Rajesh K., MD

“…Purpose To evaluate the safety and efficacy of corneal collagen crosslinking (CXL) for the treatment of progressive keratoconus. Design Prospective,…”
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Computational Drug Repositioning: From Data to Therapeutics by Hurle, M R, Yang, L, Xie, Q, Rajpal, D K, Sanseau, P, Agarwal, P

“…Traditionally, most drugs have been discovered using phenotypic or target‐based screens. Subsequently, their indications are often expanded on the basis of…”
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Empowering the discovery of novel target-disease associations via machine learning approaches in the open targets platform by Han, Yingnan, Klinger, Katherine, Rajpal, Deepak K, Zhu, Cheng, Teeple, Erin

“…Abstract Background The Open Targets (OT) Platform integrates a wide range of data sources on target-disease associations to facilitate identification of…”
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An integrative network-based approach for drug target indication expansion by Han, Yingnan, Wang, Clarence, Klinger, Katherine, Rajpal, Deepak K, Zhu, Cheng

“…Background The identification of a target-indication pair is regarded as the first step in a traditional drug discovery and development process. Significant…”
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Network-Based Identification and Prioritization of Key Regulators of Coronary Artery Disease Loci by Zhao, Yuqi, Chen, Jing, Freudenberg, Johannes M, Meng, Qingying, Rajpal, Deepak K, Yang, Xia

“…OBJECTIVE—Recent genome-wide association studies of coronary artery disease (CAD) have revealed 58 genome-wide significant and 148 suggestive genetic loci…”
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U.S. Multicenter Clinical Trial of Corneal Collagen Crosslinking for Treatment of Corneal Ectasia after Refractive Surgery by Hersh, Peter S., Stulting, R. Doyle, Muller, David, Durrie, Daniel S., Rajpal, Rajesh K., Binder, Perry S., Donnenfeld, Eric D., Durrie, Daniel, Hardten, David, Hersh, Peter, Price, Francis, Randleman, J. Bradley, Schanzlin, David, Stark, Walter, Stulting, R. Doyle, Trattler, William, Trokel, Steven

“…To evaluate the safety and efficacy of corneal collagen crosslinking (CXL) for the treatment of corneal ectasia after laser refractive surgery. Prospective,…”
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Preclinical evaluation of EPHX2 inhibition as a novel treatment for inflammatory bowel disease by Reisdorf, William C, Xie, Qing, Zeng, Xin, Xie, Wensheng, Rajpal, Neetu, Hoang, Bao, Burgert, Mark E, Kumar, Vinod, Hurle, Mark R, Rajpal, Deepak K, O'Donnell, Sarah, MacDonald, Thomas T, Vossenkämper, Anna, Wang, Lin, Reilly, Mike, Votta, Bart J, Sanchez, Yolanda, Agarwal, Pankaj

“…Epoxyeicosatrienoic acids (EETs) are signaling lipids produced by cytochrome P450 epoxygenation of arachidonic acid, which are metabolized by EPHX2 (epoxide…”
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A Hidradenitis Suppurativa molecular disease signature derived from patient samples by high-throughput RNA sequencing and re-analysis of previously reported transcriptomic data sets by Freudenberg, Johannes M, Liu, Zhi, Singh, Jennifer, Thomas, Elizabeth, Traini, Christopher, Rajpal, Deepak K, Sayed, Christopher J

“…Hidradenitis suppurativa (HS) is a common, debilitating inflammatory skin disease linked to immune dysregulation and abnormalities in follicular structure and…”
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First-in-human evaluation of a novel balloon-expandable transcatheter heart valve in patients with severe symptomatic native aortic stenosis: the MyVal-1 study by Sharma, Samin K., Rao, Ravinder Singh, Chandra, Praveen, Goel, Pravin Kumar, Bharadwaj, Prashant, Joseph, George, Jose, John, Mahajan, Ajaykumar U., Mehrotra, Sanjay, Sengottovelu, Gunasekaran, Ajit Kumar, V. K., Manjunath, Cholenahally N., Abhaichand, Rajpal K., Sethi, Rishi, Seth, Ashok

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Serial evaluation of vascular responses after implantation of everolimus‐eluting coronary stent by optical coherence tomography by Kaul, Upendra, Abhyankar, Atul, Abhaichand, Rajpal, Bhagwat, Ajit, Sengottuvelu, Gunasekaran, Bahuleyan, Charantharayil, Arambam, Priyadarshini, Yumnam, Diana

“…Aim To evaluate healing response at strut‐level and cross‐section level after implanting an ultra‐thin strut, everolimus‐eluting stent with biodegradable…”
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Selective Spectrum Antibiotic Modulation of the Gut Microbiome in Obesity and Diabetes Rodent Models by Rajpal, Deepak K, Klein, Jean-Louis, Mayhew, David, Boucheron, Joyce, Spivak, Aaron T, Kumar, Vinod, Ingraham, Karen, Paulik, Mark, Chen, Lihong, Van Horn, Stephanie, Thomas, Elizabeth, Sathe, Ganesh, Livi, George P, Holmes, David J, Brown, James R

“…The gastrointestinal tract microbiome has been suggested as a potential therapeutic target for metabolic diseases such as obesity and Type 2 diabetes mellitus…”
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Uncovering new disease indications for G-protein coupled receptors and their endogenous ligands by Freudenberg, Johannes M, Dunham, Ian, Sanseau, Philippe, Rajpal, Deepak K

“…The Open Targets Platform integrates different data sources in order to facilitate identification of potential therapeutic drug targets to treat human…”
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Impact of Medication Nonadherence in a Clinical Trial of Dual Antiplatelet Therapy by Valgimigli, Marco, Frigoli, Enrico, Vranckx, Pascal, Ozaki, Yukio, Morice, Marie-Claude, Chevalier, Bernard, Onuma, Yoshinobu, Windecker, Stephan, Delorme, Laurent, Kala, Petr, Kedev, Sasko, Abhaichand, Rajpal K., Velchev, Vasil, Dewilde, Willem, Podolec, Jakub, Leibundgut, Gregor, Topic, Dragan, Schultz, Carl, Stankovic, Goran, Lee, Astin, Johnson, Thomas, Tonino, Pim A.L., Klotzka, Aneta, Lesiak, Maciej, Lopes, Renato D., Smits, Pieter C., Heg, Dik

“…BACKGROUNDNonadherence to antiplatelet therapy after percutaneous coronary intervention (PCI) is common, even in clinical trials. OBJECTIVESThe purpose of this…”
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Genetic Ablation of CD38 Protects against Western Diet-Induced Exercise Intolerance and Metabolic Inflexibility by Chiang, Shian-Huey, Harrington, W Wallace, Luo, Guizhen, Milliken, Naphtali O, Ulrich, John C, Chen, Jing, Rajpal, Deepak K, Qian, Ying, Carpenter, Tiffany, Murray, Rusty, Geske, Robert S, Stimpson, Stephen A, Kramer, Henning F, Haffner, Curt D, Becherer, J David, Preugschat, Frank, Billin, Andrew N

“…Nicotinamide adenine dinucleotide (NAD+) is a key cofactor required for essential metabolic oxidation-reduction reactions. It also regulates various cellular…”
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TCTAP A-002 Evaluation of Vascular Response and Healing After Implantation of Tetrilimus Everolimus-eluting Coronary Stent by Optical Coherence Tomography (EVER-OCT): 3 and 6 Month Serial Analysis by Kaul, Upendra, Abhaichand, Rajpal K., Abhyankar, Atul, Bhagwat, Ajit, Sengottuvelu, G., Bahuleyan, C.G., Arambam, Priyadarshini, Yumnam, Diana

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TCT-457 Paclitaxel - eluting stents vs Everolimus - eluting Coronary Stents in a Diabetic population: 2 Years Follow-up of TUXEDO-India Trial by Kaul, Upendra, Abhaichand, Dr. Rajpal K, Patel, Tejas, Banker, Darshan, Abhyankar, Atul, Mullasari, Ajit, Shah, Sanjay, Jain, Rajneesh, premchand rajendra kumar, Bahuleyan, C.G, Arambam, Priyadarshini, Bangalore, Sripal

“…There was a significantly higher 1-year rate in the PES group than in the EES group of target-vessel failure (TVF) (p = 0.005), spontaneous MI (p = 0.004),…”
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Phenome-wide association study using research participants' self-reported data provides insight into the Th17 and IL-17 pathway by Ehm, Margaret G, Aponte, Jennifer L, Chiano, Mathias N, Yerges-Armstrong, Laura M, Johnson, Toby, Barker, Jonathan N, Cook, Suzanne F, Gupta, Akanksha, Hinds, David A, Li, Li, Nelson, Matthew R, Simpson, Michael A, Tian, Chao, McCarthy, Linda C, Rajpal, Deepak K, Waterworth, Dawn M

“…A phenome-wide association study of variants in genes in the Th17 and IL-17 pathway was performed using self-reported phenotypes and genetic data from 521,000…”
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Genome-Wide Association Study and Gene-Based Analysis of Participants With Hemophilia A and Inhibitors in the My Life, Our Future Research Repository by Lessard, Samuel, He, Chunla, Rajpal, Deepak K., Klinger, Katherine, Loh, Christine, Harris, Tim, Dumont, Jennifer

“…Introduction Up to 30% of individuals with hemophilia A develop inhibitors to replacement factor VIII (FVIII), rendering the treatment ineffective. The…”
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