Three-year evaluation of the nosocomial infections in pediatrics: bacterial and fungal profile and antimicrobial resistance pattern

Nosocomial infections (NIs) could lead to considerably higher mortality rates, length of the hospital stays and costs, and represent a serious public health concern worldwide. Besides, the unreasonable use of antibiotics could lead to get resistant to different antibiotics and create limited therape...

Full description

Saved in:

Bibliographic Details
Published in:	Annals of clinical microbiology and antimicrobials Vol. 21; no. 1; p. 6
Main Authors:	Afsharipour, Mehrnoush, Mahmoudi, Shima, Raji, Hojatollahh, Pourakbari, Babak, Mamishi, Setareh
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 16-02-2022 BioMed Central BMC
Subjects:	Analysis Anti-Bacterial Agents - therapeutic use Antibiotic resistance Antibiotics Antimicrobial agents Antimicrobial resistance Antimicrobial susceptibility Bacteria Bacterial infections Bacterial pneumonia Candida Care and treatment Child, Preschool Ciprofloxacin Coagulase Control programs Cross Infection - drug therapy Cross Infection - epidemiology Cross Infection - microbiology Disease susceptibility Drug resistance in microorganisms Drug Resistance, Bacterial - drug effects E coli Electronic health records Electronic medical records Fungi Gram-negative bacteria Gram-positive bacteria Health aspects Hospital patients Hospitals Humans Infant Intensive care Iran Iran - epidemiology Klebsiella Klebsiella pneumoniae Male Medical care, Cost of Medical records Medical research Medicine, Experimental Methicillin Microbial Sensitivity Tests Microorganisms Mortality Nosocomial infection Nosocomial infections Patients Pediatrics Penicillin Pneumonia Pseudomonas aeruginosa Public health Retrospective Studies Serbia Staphylococcus aureus Staphylococcus aureus - drug effects Staphylococcus infections Strains (organisms) Streptococcus infections Sulfamethoxazole Trimethoprim Vancomycin Iran Serbia Pediatrics Antimicrobial susceptibility Nosocomial infections
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Nosocomial infections (NIs) could lead to considerably higher mortality rates, length of the hospital stays and costs, and represent a serious public health concern worldwide. Besides, the unreasonable use of antibiotics could lead to get resistant to different antibiotics and create limited therapeutic options, increased risks of treatment failure and poor patient management. The current study aimed to evaluate the prevalence and antimicrobial susceptibility of NIs in an Iranian referral pediatrics hospital during 3 years. During the 3-year period, all electronic medical records of nosocomial infection episodes in hospitalized patients were retrospectively reviewed. The bacterial and fungal profile and antimicrobial susceptibility profiles of isolates recovered from different samples of patients with NIs were determined. In this study, a total of 718 patients with NIs was found, among which 61.3% were male (N = 440). The median age of the patients was 2.5 years (IQR: 1 month to 3 years). Klebsiella pneumonia and Candida spp. isolates were the most prevalent microorganisms (N = 125, 17.4%, N = 121, 16.9%, respectively), followed by Pseudomonas aeruginosa (N = 72, 10%) and Coagulase-negative Staphylococci (CoNS) (N = 69, 9.6%). Pseudomonas aeroginusa strains showed high sensitivity to the studied antibiotics. Acinetobacter baumannii strains displayed more than 90% resistance to the almost all antibiotics. All of the tested isolates of S. maltophilia were susceptible to Trimethoprim-sulfamethoxazole (100%) and showed high susceptibility rate to ciprofloxacin (96.4%). Vancomycin resistance was not reported in S. aureus isolates, while 64% of Enterococcus spp. was resistant to vancomycin. The rates of methicillin resistance for S. aureus and CoNS isolates were 45.5% and 85.7%, respectively. High frequency of antimicrobial resistance to the commonly tested antibiotics is a concerning alarm. Therefore, effective infection control programs and rational antibiotic use policies should be established promptly.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1476-0711 1476-0711
DOI:	10.1186/s12941-022-00496-5