Search Results - "Rajewsky, M. F."

Three-Dimensional Imaging of Nerve Tissue by X-Ray Phase-Contrast Microtomography by Beckmann, F., Heise, K., Kölsch, B., Bonse, U., Rajewsky, M.F., Bartscher, M., Biermann, T.

“…We show that promising information about the three-dimensional (3D) structure of a peripheral nerve can be obtained by x-ray phase-contrast microtomography (p-…”
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pH in human tumour xenografts: effect of intravenous administration of glucose by Volk, T, Jähde, E, Fortmeyer, H P, Glüsenkamp, K H, Rajewsky, M F

“…pH frequency distributions of tumours grown s.c. from 30 human tumour xenograft lines in rnu/rnu rats were analysed with the use of H+ ion-sensitive…”
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Alternative pathways for the in vivo repair of O6‐alkylguanine and O4‐alkylthymine in Escherichia coli: the adaptive response and nucleotide excision repair by Samson, L., Thomale, J., Rajewsky, M. F.

“…The in vivo removal of three different O‐alkylated bases from DNA was measured in Escherichia coli. Using monoclonal antibodies specific for O6‐methylguanine,…”
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DNA excision repair profiles of normal and leukemic human lymphocytes : Functional analysis at the single-cell level by BUSCHFORT, C, MÜLLER, M. R, SEEBER, S, RAJEWSKY, M. F, THOMALE, J

“…Recent evidence has linked cellular DNA repair capacity to the chemosensitivity of cancer cells to alkylating agents. Using single-cell gel electrophoresis…”
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DNA repair and cellular resistance to alkylating agents in chronic lymphocytic leukemia by MÜLLER, M. R, BUSCHFORT, C, THOMALE, J, LENSING, C, RAJEWSKY, M. F, SEEBER, S

“…The time course of the formation and persistence of repair-induced DNA lesions such as single-strand breaks (SSBs) were determined in isolated lymphocytes…”
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Differential formation and repair of the mutagenic DNA alkylation product O6-ethylguanine in transcribed and nontranscribed genes of the rat by THOMALE, J, HOCHLEITNER, K, RAJEWSKY, M. F

“…Intragenomic differences regarding the formation and repair of carcinogen-DNA adducts influence gene-specific mutational patterns and the cellular risk of…”
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Early Mutation of the neu (erbB-2) Gene During Ethylnitrosourea-Induced Oncogenesis in the Rat Schwann Cell Lineage by Alexander Yu. Nikitin, Leo A. P. Ballering, Lyons, John, Rajewsky, Manfred F.

“…The development of malignant tumors of the peripheral nervous system (schwannomas) within a defined intracranial section of the rat trigeminal nerve…”
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Immunoaffinity purification and gas chromatography-mass spectrometric quantification of 3-alkyladenines in urine: metabolism studies and basal excretion levels in man by Prevost, V, Shuker, D E, Friesen, M D, Eberle, G, Rajewsky, M F, Bartsch, H

“…Immunoaffinity gels were prepared by coupling monoclonal antibody (Mab) EM-6-47 to protein A-Sepharose, and were used to make small columns retaining…”
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Suppression of ethylnitrosourea-induced schwannoma development involves elimination of neu/erbB-2 mutant premalignant cells in the resistant BDIV rat strain by KINDLER-RÖHRBORN, Andrea, KIND, André B, KOELSCH, Bernd U, FISCHER, Christine, RAJEWSKY, Manfred F

“…Contrary to the response of rats of the highly sensitive inbred strain BDIX, BDIV rats are resistant to the induction of malignant schwannomas by exposure to…”
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Sixth Japanese‐German workshop on molecular and cellular aspects of carcinogenesis by Kuroki, Toshio, Rajewsky, Manfred F.

“…Meeting held at Essen, Germany, 4–6 September, 1997 © 1998 Wiley‐Liss, Inc…”
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Rapid hydrolysis of amides under physiological conditions: Influence of the microenvironment on the stability of the amide bond by Glüsenkamp, K.-H., Mengede, C., Drosdziok, W., Jähde, E., Rajewsky, M.F.

“…A new class of bicyclic carboxyamides 1a-9a differing with respect to substitution patterns and exoendo geometry has been synthesized. These amides are…”
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Reduction of intratumoral pH by the mitochondrial inhibitor m-iodobenzylguanidine and moderate hyperglycemia by KUIN, A, SMETS, L, WOOD, P, VOLK, T, PAANS, A, ADAMS, G, ATEMA, A, JÄHDE, E, MAAS, A, RAJEWSKY, M. F, VISSER, G

“…The interstitial pH of RIF-1 tumors was selectively lowered by i.p. administration of the mitochondrial inhibitor meta-iodobenzylguanidine (MIBG; 40-100…”
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In vitro differentiation of E-N-CAM expressing rat neural precursor cells isolated by FACS during prenatal development by Blass-Kampmann, S, Reinhardt-Maelicke, S, Kindler-Röhrborn, A, Cleeves, V, Rajewsky, M F

“…Most fetal rat brain cells expressing the embryonal, highly sialylated form of the cell adhesion molecule N-CAM (E-N-CAM) are precursor cells, as judged from…”
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Quantification of specific DNA O-alkylation products in individual cells by monoclonal antibodies and digital imaging of intensified nuclear fluorescence by Seiler, F, Kirstein, U, Eberle, G, Hochleitner, K, Rajewsky, M F

“…We report the establishment of a standardized, monoclonal antibody (Mab)-based immunocytological assay (quantitative ICA) for the visualization and…”
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1,N6-etheno-2'-deoxyadenosine and 3,N4-etheno-2'-deoxycytidine detected by monoclonal antibodies in lung and liver DNA of rats exposed to vinyl chloride by Eberle, G, Barbin, A, Laib, R J, Ciroussel, F, Thomale, J, Bartsch, H, Rajewsky, M F

“…1,N6-Etheno-2'-deoxyadenosine (epsilon dAdo) and 3,N4-etheno-2'-deoxycytidine (epsilon dCyd) are formed in vitro by reaction of DNA with the electrophilic…”
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Repair of O6-alkylguanines in the nuclear DNA of human lymphocytes and leukaemic cells : analysis at the single-cell level by THOMALE, J, SEILER, F, MÜLLER, M. R, SEEBER, S, RAJEWSKY, M. F

“…Inter-individual and cell-cell variability of repair of O6-alkylguanines (O6-AlkGua) in nuclear DNA was studied at the single-cell level in peripheral…”
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Determination of immunoreactive fraction and kinetic parameters of a radiolabeled monoclonal antibody in the absence of antigen excess by Dux, R, Kindler-Röhrborn, A, Lennartz, K, Rajewsky, M F

“…Monoclonal antibodies (Mabs) directed against cell surface determinants and conjugated to fluochromes, radionuclids or drugs are of increasing importance in…”
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Concordance between parental origin of chromosome 13q loss and chromosome 6p duplication in sporadic retinoblastoma by NAUMOVA, A, HANSEN, M, WANG, M, SAPIENZA, C, STRONG, L, JONES, P. A, HADJISTILIANOU, D, MASTRANGELO, D, GRIEGEL, S, RAJEWSKY, M. F, SHIELDS, J, DONOSO, L

“…Two hypotheses are capable of explaining nonrandom loss of one parent's alleles at tumor suppressor loci in sporadic cases of several pediatric cancers,…”
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Immuno-slot-blot: a highly sensitive immunoassay for the quantitation of carcinogen-modified nucleosides in DNA by NEHLS, P, ADAMKIEWICZ, J, RAJEWSKY, M. F

“…We have established a highly sensitive immuno-slot-blot (ISB) procedure that can be routinely applied for detection and quantitation of any heat- or…”
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Cytotoxicity of adriamycin, idarubicin, and vincristine in acute myeloid leukemia : chemosensitization by verapamil in relation to P-glycoprotein expression by MÜLLER, M. R, LENNARTZ, K, BOOGEN, C, NOWROUSIAN, M. R, RAJEWSKY, M. F, SEEBER, S

“…A 4-day colorimetric tetrazolium dye (MTT) assay was used to assess the cytotoxicity of adriamycin (ADM), vincristine (VCR), and idarubicin (IDA) in blasts…”
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