Search Results - "Rajeswaran, Walajapet"

Optimization of Eliglustat-Based Glucosylceramide Synthase Inhibitors as Substrate Reduction Therapy for Gaucher Disease Type 3 by Wilson, Michael W, Shu, Liming, Hinkovska-Galcheva, Vania, Jin, Yafei, Rajeswaran, Walajapet, Abe, Akira, Zhao, Ting, Luo, Ruijuan, Wang, Lu, Wen, Bo, Liou, Benjamin, Fannin, Venette, Sun, Duxin, Sun, Ying, Shayman, James A, Larsen, Scott D

“…There remain no approved therapies for rare but devastating neuronopathic glyocosphingolipid storage diseases, such as Sandhoff, Tay-Sachs, and Gaucher disease…”
Get full text

Novel inhibitors of bacterial virulence: Development of 5,6-dihydrobenzo[h]quinazolin-4(3H)-ones for the inhibition of group A streptococcal streptokinase expression by Yestrepsky, Bryan D., Xu, Yuanxi, Breen, Meghan E., Li, Xiaoqin, Rajeswaran, Walajapet G., Ryu, Jenny G., Sorenson, Roderick J., Tsume, Yasuhiro, Wilson, Michael W., Zhang, Wenpeng, Sun, Duxin, Sun, Hongmin, Larsen, Scott D.

“…Resistance to antibiotics is an increasingly dire threat to human health that warrants the development of new modes of treating infection. We recently…”
Get full text

Massive Bioaccumulation and Self‐Assembly of Phenazine Compounds in Live Cells by Min, Kyoung Ah, Rajeswaran, Walajapet G., Oldenbourg, Rudolf, Harris, Grant, Keswani, Rahul K., Chiang, Mason, Rzeczycki, Phillip, Talattof, Arjang, Hafeez, Mahwish, Horobin, Richard W., Larsen, Scott D., Stringer, Kathleen A., Rosania, Gus R.

“…Clofazimine is an orally administered drug that massively bioaccumulates in macrophages, forming membrane‐bound intracellular structures possessing nanoscale…”
Get full text

Synthesis of 5-[(Indol-2-on-3-yl)methyl]-2,2-dimethyl-1,3- dioxane-4,6-diones and Spirocyclopropyloxindole Derivatives. Potential Aldose Reductase Inhibitors by Rajeswaran, Walajapet G, Labroo, Rita B, Cohen, Louis A, King, Michael M

Get full text

The Physicochemical Basis of Clofazimine-Induced Skin Pigmentation by Murashov, Mikhail D., LaLone, Vernon, Rzeczycki, Phillip M., Keswani, Rahul K., Yoon, Gi S., Sud, Sudha, Rajeswaran, Walajapet, Larsen, Scott, Stringer, Kathleen A., Rosania, Gus R.

“…Clofazimine is a weakly basic, Food and Drug Administration-approved antibiotic recommended by the World Health Organization to treat leprosy and…”
Get full text

Pharmacokinetic optimitzation of CCG-203971: Novel inhibitors of the Rho/MRTF/SRF transcriptional pathway as potential antifibrotic therapeutics for systemic scleroderma by Hutchings, Kim M., Lisabeth, Erika M., Rajeswaran, Walajapet, Wilson, Michael W., Sorenson, Roderick J., Campbell, Phillip L., Ruth, Jeffrey H., Amin, Asif, Tsou, Pei-Suen, Leipprandt, Jeffrey R., Olson, Samuel R., Wen, Bo, Zhao, Ting, Sun, Duxin, Khanna, Dinesh, Fox, David A., Neubig, Richard R., Larsen, Scott D.

“…[Display omitted] We recently reported the development of a novel inhibitor of Rho-mediated gene transcription (1, CCG-203971) that is efficacious in multiple…”
Get full text

CARP-1 functional mimetics are novel inhibitors of drug-resistant triple negative breast cancers by Cheriyan, Vino T, Muthu, Magesh, Patel, Ketan, Sekhar, Sreeja, Rajeswaran, Walajapet, Larsen, Scott D, Polin, Lisa, Levi, Edi, Singh, Mandip, Rishi, Arun K

“…Doxorubicin and Cisplatin are the frontline therapeutics for treatment of the triple negative breast cancers (TNBCs). Emergence of drug-resistance often…”
Get full text

Optimization of Benzoxazinorifamycins to Improve Mycobacterium tuberculosis RNA Polymerase Inhibition and Treatment of Tuberculosis by Rajeswaran, Walajapet, Ashkar, Shireen R., Lee, Pil H., Yeomans, Larisa, Shin, Yeonoh, Franzblau, Scott G., Murakami, Katsuhiko S., Showalter, Hollis D., Garcia, George A.

“…Rifampin (RMP), a very potent inhibitor of the Mycobacterium tuberculosis (MTB) RNA polymerase (RNAP), remains a keystone in the treatment of tuberculosis…”
Get full text

Optimization of Benzoxazinorifamycins to Minimize hPXR Activation for the Treatment of Tuberculosis and HIV Coinfection by Ashkar, Shireen R., Rajeswaran, Walajapet, Lee, Pil H., Yeomans, Larisa, Thrasher, Claire M., Franzblau, Scott G., Murakami, Katsuhiko S., Showalter, Hollis D., Garcia, George A.

“…Tuberculosis (TB) is one of the most significant world health problems, responsible for 1.5 M deaths in 2020, and yet, current treatments rely largely on 40…”
Get full text

Pharmacokinetic Optimization of CCG-203971: Novel Inhibitors of the Rho/MRTF/SRF Transcriptional Pathway as Potential Antifibrotic Therapeutics for Systemic Scleroderma by Hutchings, Kim M., Lisabeth, Erika M., Rajeswaran, Walajapet, Wilson, Michael W., Sorenson, Roderick J., Campbell, Phillip L., Ruth, Jeffrey H., Amin, Asif, Tsou, Pei-Suen, Leipprandt, Jeffrey R., Olson, Samuel R., Wen, Bo, Zhao, Ting, Sun, Duxin, Khanna, Dinesh, Fox, David A., Neubig, Richard R., Larsen, Scott D.

“…We recently reported the development of a novel inhibitor of Rho-mediated gene transcription ( 1 , CCG-203971) that is efficacious in multiple animal models of…”
Get full text

Studies on protection of oxindoles by Rajeswaran, Walajapet G., Cohen, Louis A.

“…Protection of amide nitrogen of oxindole and methyloxindole using Boc and Z-groups has been described. Sodium carbonate was found to be an effective base for…”
Get full text

A convenient method of protecting oxindoles by Rajeswaran, Walajapet G., Cohen, Louis A.

“…The nitrogens of oxindoles and indole were protected by dichloroacetyl group in refluxing DCE. The deprotection of these protected oxindoles and indole has…”
Get full text