Catalytic, Theoretical, and Biological Investigations of Ternary Metal (II) Complexes Derived from L-Valine-Based Schiff Bases and Heterocyclic Bases

A new series of ternary metal complexes, including Co(II), Ni(II), Cu(II), and Zn(II), were synthesized and characterized by elemental analysis and diverse spectroscopic methods. The complexes were synthesized from respective metal salts with Schiff's-base-containing amino acids, salicylaldehyd...

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Bibliographic Details
Published in:	Molecules (Basel, Switzerland) Vol. 28; no. 7; p. 2931
Main Authors:	Sasikumar, Gopalakrishnan, Subramani, Annadurai, Tamilarasan, Ramalingam, Rajesh, Punniyamurthy, Sasikumar, Ponnusamy, Albukhaty, Salim, Mohammed, Mustafa K A, Karthikeyan, Subramani, Al-Aqbi, Zaidon T, Al-Doghachi, Faris A J, Taufiq-Yap, Yun Hin
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 24-03-2023 MDPI
Subjects:	Amino acids Analysis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial activity binding interaction Breast cancer Carbonyl compounds Carbonyls Cervical cancer Coordination Complexes - chemistry Coordination Complexes - pharmacology Copper Copper - chemistry Cu(II) complexes Cytotoxicity Electrochemistry Escherichia coli Heterocyclic compounds Humans Imines Investigations L-valine Ligands Lung cancer Metal complexes Metal ions Metals - chemistry Molecular structure Oxidation Potassium Schiff bases Schiff Bases - chemistry Schiff Bases - pharmacology Spectroscopic analysis Staphylococcus aureus ternary metal Valine Iraq India antibacterial activity Cu(II) complexes binding interaction ternary metal L-valine
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Summary:	A new series of ternary metal complexes, including Co(II), Ni(II), Cu(II), and Zn(II), were synthesized and characterized by elemental analysis and diverse spectroscopic methods. The complexes were synthesized from respective metal salts with Schiff's-base-containing amino acids, salicylaldehyde derivatives, and heterocyclic bases. The amino acids containing Schiff bases showed promising pharmacological properties upon complexation. Based on satisfactory elemental analyses and various spectroscopic techniques, these complexes revealed a distorted, square pyramidal geometry around metal ions. The molecular structures of the complexes were optimized by DFT calculations. Quantum calculations were performed with the density functional method for which the LACVP++ basis set was used to find the optimized molecular structure of the complexes. The metal complexes were subjected to an electrochemical investigation to determine the redox behavior and oxidation state of the metal ions. Furthermore, all complexes were utilized for catalytic assets of a multi-component Mannich reaction for the preparation of -amino carbonyl derivatives. The synthesized complexes were tested to determine their antibacterial activity against , , and bacteria. To evaluate the cytotoxic effects of the Cu(II) complexes, lung cancer (A549), cervical cancer (HeLa), and breast cancer (MCF-7) cells compared to normal cells, cell lines such as human dermal fibroblasts (HDF) were used. Further, the docking study parameters were supported, for which it was observed that the metal complexes could be effective in anticancer applications.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules28072931