Search Results - "Rajesh, Mohanraj"

Fisetin Confers Cardioprotection against Myocardial Ischemia Reperfusion Injury by Suppressing Mitochondrial Oxidative Stress and Mitochondrial Dysfunction and Inhibiting Glycogen Synthase Kinase 3β Activity by Mohanraj, Rajesh, Kurian, Gino A., Ravindran, Sriram, Shanmugam, Karthi

“…Acute myocardial infarction (AMI) is the leading cause of morbidity and mortality worldwide. Timely reperfusion is considered an optimal treatment for AMI…”
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The Role of Oxidative Stress in Myocardial Ischemia and Reperfusion Injury and Remodeling: Revisited by Mohanraj, Rajesh, Vedantham, Srinivasan, Rajagopal, Rashmi, Kurian, Gino A.

“…Oxidative and reductive stress are dual dynamic phases experienced by the cells undergoing adaptation towards endogenous or exogenous noxious stimulus. The…”
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Cannabidiol Attenuates Cardiac Dysfunction, Oxidative Stress, Fibrosis, and Inflammatory and Cell Death Signaling Pathways in Diabetic Cardiomyopathy by Rajesh, Mohanraj, PhD, Mukhopadhyay, Partha, PhD, Bátkai, Sándor, MD, PhD, Patel, Vivek, Saito, Keita, PhD, Matsumoto, Shingo, PhD, Kashiwaya, Yoshihiro, MD, PhD, Horváth, Béla, MD, PhD, Mukhopadhyay, Bani, PhD, Becker, Lauren, Haskó, György, MD, PhD, Liaudet, Lucas, MD, Wink, David A., PhD, Veves, Aristidis, MD, Mechoulam, Raphael, PhD, Pacher, Pál, MD, PhD

“…Objectives In this study, we have investigated the effects of cannabidiol (CBD) on myocardial dysfunction, inflammation, oxidative/nitrative stress, cell…”
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Potential role of genipin in cancer therapy by Shanmugam, Muthu K., Shen, Hongyuan, Tang, Feng Ru, Arfuso, Frank, Rajesh, Mohanraj, Wang, Lingzhi, Kumar, Alan Prem, Bian, Jinsong, Goh, Boon Cher, Bishayee, Anupam, Sethi, Gautam

“…[Display omitted] Genipin, an aglycone derived from the iridoid glycoside, geniposide, is isolated and characterized from the extract of Gardenia jasminoides…”
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Plant-Derived Agents for Counteracting Cisplatin-Induced Nephrotoxicity by Sadek, Bassem, Mahgoub, Eglal, Kurdi, Amani, Venkataraman, Balaji, Ojha, Shreesh, Mohanraj, Rajesh

“…Cisplatin (CSP) is a chemotherapeutic agent commonly used to treat a variety of malignancies. The major setback with CSP treatment is that its clinical…”
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PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis by Mukhopadhyay, Partha, Horváth, Béla, Rajesh, Mohanraj, Varga, Zoltán V, Gariani, Karim, Ryu, Dongryeol, Cao, Zongxian, Holovac, Eileen, Park, Ogyi, Zhou, Zhou, Xu, Ming-Jiang, Wang, Wei, Godlewski, Grzegorz, Paloczi, Janos, Nemeth, Balazs Tamas, Persidsky, Yuri, Liaudet, Lucas, Haskó, György, Bai, Peter, Boulares, A. Hamid, Auwerx, Johan, Gao, Bin, Pacher, Pal

“…Graphical abstract…”
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Cannabinoid 1 Receptor Promotes Cardiac Dysfunction, Oxidative Stress, Inflammation, and Fibrosis in Diabetic Cardiomyopathy by RAJESH, Mohanraj, BATKAI, Sándor, HASKO, Gyorgy, PACHER, Pál, KECHRID, Malek, MUKHOPADHYAY, Partha, LEE, Wen-Shin, HORVATH, Bela, HOLOVAC, Eileen, CINAR, Resat, LIAUDET, Lucas, MACKIE, Ken

“…Endocannabinoids and cannabinoid 1 (CB(1)) receptors have been implicated in cardiac dysfunction, inflammation, and cell death associated with various forms of…”
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Protection by dimethyl fumarate against diabetic cardiomyopathy in type 1 diabetic mice likely via activation of nuclear factor erythroid-2 related factor 2 by Hu, Xinyue, Rajesh, Mohanraj, Zhang, Jian, Zhou, Shanshan, Wang, Shudong, Sun, Jian, Tan, Yi, Zheng, Yang, Cai, Lu

“…•DMF can reduce diabetes-induced cardiac structural damage and dysfunction.•Cardiac protection by DMF from diabetes is likely mediated by Nrf2 antioxidant…”
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Editorial: Cardiovascular diseases related to diabetes and obesity, volume III by Xin, Ying, Wise, Jamie Young, Rajesh, Mohanraj, Cai, Lu

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Cardioprotective Potentials of Plant-Derived Small Molecules against Doxorubicin Associated Cardiotoxicity by Mohanraj, Rajesh, Patil, Chandrgouda R., Mahajan, Umesh B., Goyal, Sameer N., Al Taee, Hasan, Ojha, Shreesh, Arya, Dharmveer S.

“…Doxorubicin (DOX) is a potent and widely used anthracycline antibiotic for the treatment of several malignancies. Unfortunately, the clinical utility of DOX is…”
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Simultaneous detection of apoptosis and mitochondrial superoxide production in live cells by flow cytometry and confocal microscopy by Pacher, Pál, Mukhopadhyay, Partha, Rajesh, Mohanraj, Haskó, György, Hawkins, Brian J, Madesh, Muniswamy

“…Annexin V and Sytox Green are widely used markers to evaluate apoptosis in various cell types using flow cytometry and fluorescent microscopy. Recently, a…”
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Role of superoxide, nitric oxide, and peroxynitrite in doxorubicin-induced cell death in vivo and in vitro by Mukhopadhyay, Partha, Rajesh, Mohanraj, Bátkai, Sándor, Kashiwaya, Yoshihiro, Haskó, György, Liaudet, Lucas, Szabó, Csaba, Pacher, Pál

“…Doxorubicin (DOX) is a potent available antitumor agent; however, its clinical use is limited because of its cardiotoxicity. Cell death is a key component in…”
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Cannabidiol protects against hepatic ischemia/reperfusion injury by attenuating inflammatory signaling and response, oxidative/nitrative stress, and cell death by Mukhopadhyay, Partha, Rajesh, Mohanraj, Horváth, Béla, Bátkai, Sándor, Park, Ogyi, Tanchian, Galin, Gao, Rachel Y., Patel, Vivek, Wink, David A., Liaudet, Lucas, Haskó, György, Mechoulam, Raphael, Pacher, Pál

“…Ischemia/reperfusion (I/R) is a pivotal mechanism of liver damage after liver transplantation or hepatic surgery. We have investigated the effects of…”
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Cannabinoid-2 receptor limits inflammation, oxidative/nitrosative stress, and cell death in nephropathy by Mukhopadhyay, Partha, Rajesh, Mohanraj, Pan, Hao, Patel, Vivek, Mukhopadhyay, Bani, Bátkai, Sándor, Gao, Bin, Haskó, György, Pacher, Pál

“…Cisplatin is an important chemotherapeutic agent; however, its nephrotoxicity limits its clinical use. Enhanced inflammatory response and oxidative/nitrosative…”
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Poly (ADP‐ribose) polymerase‐1 is a key mediator of liver inflammation and fibrosis by Mukhopadhyay, Partha, Rajesh, Mohanraj, Cao, Zongxian, Horváth, Béla, Park, Ogyi, Wang, Hua, Erdelyi, Katalin, Holovac, Eileen, Wang, Yuping, Liaudet, Lucas, Hamdaoui, Nabila, Lafdil, Fouad, Haskó, György, Szabo, Csaba, Boulares, A. Hamid, Gao, Bin, Pacher, Pal

“…Poly (ADP‐ribose) polymerase 1 (PARP‐1) is a constitutive enzyme, the major isoform of the PARP family, which is involved in the regulation of DNA repair, cell…”
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CB1 cannabinoid receptors promote oxidative stress and cell death in murine models of doxorubicin-induced cardiomyopathy and in human cardiomyocytes by Mukhopadhyay, Partha, Rajesh, Mohanraj, Bátkai, Sándor, Patel, Vivek, Kashiwaya, Yoshihiro, Liaudet, Lucas, Evgenov, Oleg V., Mackie, Ken, Haskó, György, Pacher, Pál

“…Aims Here we investigated the mechanisms by which cardiovascular CB1 cannabinoid receptors may modulate the cardiac dysfunction, oxidative stress, and…”
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Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation, and cell death by Pan, Hao, Mukhopadhyay, Partha, Rajesh, Mohanraj, Patel, Vivek, Mukhopadhyay, Bani, Gao, Bin, Haskó, György, Pacher, Pál

“…The platinum compound cisplatin is one of the most potent chemotherapy agents available to treat various malignancies. Nephrotoxicity is a common complication…”
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Cannabinoid‐1 receptor activation induces reactive oxygen species‐dependent and ‐independent mitogen‐activated protein kinase activation and cell death in human coronary artery endothelial cells by Rajesh, Mohanraj, Mukhopadhyay, Partha, Haskó, György, Liaudet, Lucas, Mackie, Ken, Pacher, Pál

“…Background and purpose:  Impaired endothelial activity and/or cell death play a critical role in the development of vascular dysfunction associated with…”
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Editorial: Cardiovascular diseases related to diabetes and obesity – volume II by Young, Jamie L., Xin, Ying, Rajesh, Mohanraj, Cai, Lu

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Editorial: Cardiovascular Diseases Related to Diabetes and Obesity by Rajesh, Mohanraj, Xin, Ying, Young, Jamie L, Cai, Lu

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