Search Results - "Rajendra Raghow"

Statins redux: A re-assessment of how statins lower plasma cholesterol by Raghow, Rajendra

“…Obesity associated dyslipidemia and its negative effects on the heart and blood vessels have emerged as a major healthcare challenge around the globe. The use…”
Get full text

Gut-brain crosstalk regulates craving for fatty food by Raghow, Rajendra

“…Patients undergoing Roux-en-Y gastric bypass(RYGB)surgery elicit striking loss of body weight. Anatomical restructuring of the gastrointestinal(GI) tract,…”
Get full text

Betatrophin:A liver-derived hormone for the pancreatic β-cell proliferation by Raghow, Rajendra

“…The pancreaticβ-cell failure which invariably accompanies insulin resistance in the liver and skeletal muscle is a hallmark of type-2 diabetes…”
Get full text

Docosahexaenoic acid inhibits proteolytic processing of sterol regulatory element-binding protein-1c (SREBP-1c) via activation of AMP-activated kinase by Deng, Xiong, Dong, Qingming, Bridges, Dave, Raghow, Rajendra, Park, Edwards A., Elam, Marshall B.

“…In hyperinsulinemic states including obesity and T2DM, overproduction of fatty acid and triglyceride contributes to steatosis of the liver, hyperlipidemia and…”
Get full text

Insulin-induced de novo lipid synthesis occurs mainly via mTOR-dependent regulation of proteostasis of SREBP-1c by Dong, Qingming, Majumdar, Gipsy, O’Meally, Robert N., Cole, Robert N., Elam, Marshall B., Raghow, Rajendra

“…Insulin stimulates de novo lipid synthesis in the liver and in cultured hepatocytes via its ability to activate sterol regulatory element-binding protein 1c…”
Get full text

SREBPs: the crossroads of physiological and pathological lipid homeostasis by Raghow, Rajendra, Yellaturu, Chandrahasa, Deng, Xiong, Park, Edwards A, Elam, Marshall B

“…The uptake, biosynthesis and metabolism of cholesterol and other lipids are exquisitely regulated by feedback and feed-forward pathways in organisms ranging…”
Get full text

FoxO1 Inhibits Sterol Regulatory Element-binding Protein-1c (SREBP-1c) Gene Expression via Transcription Factors Sp1 and SREBP-1c by Deng, Xiong, Zhang, Wenwei, O-Sullivan, InSug, Williams, J. Bradley, Dong, Qingming, Park, Edwards A., Raghow, Rajendra, Unterman, Terry G., Elam, Marshall B.

“…Induction of lipogenesis in response to insulin is critically dependent on the transcription factor, sterol regulatory element-binding protein-1c (SREBP-1c)…”
Get full text

Effect of statin treatment on metabolites, lipids and prostanoids in patients with Statin Associated Muscle Symptoms (SAMS) by Garrett, Timothy J, Puchowicz, Michelle A, Park, Edwards A, Dong, Qingming, Farage, Gregory, Childress, Richard, Guingab, Joy, Simpson, Claire L, Sen, Saunak, Brogdon, Elizabeth C, Buchanan, Logan M, Raghow, Rajendra, Elam, Marshall B

“…Between 5-10% of patients discontinue statin therapy due to statin-associated adverse reactions, primarily statin associated muscle symptoms (SAMS). The…”
Get full text

Bariatric surgery-mediated weight loss and its metabolic consequences for type-2 diabetes by Raghow, Rajendra

“…The worldwide epidemic of obesity and its medical complications are being dealt with a combination of life style changes(e.g.,healthier diet and…”
Get full text

A critical role of Sp1 transcription factor in regulating gene expression in response to insulin and other hormones by Solomon, Solomon S., Majumdar, Gipsy, Martinez-Hernandez, Antonio, Raghow, Rajendra

“…Specificity protein 1 (Sp1) belongs to a family of ubiquitously expressed, C 2H 2-type zinc finger-containing DNA binding proteins that activate or repress…”
Get full text

Patients experiencing statin-induced myalgia exhibit a unique program of skeletal muscle gene expression following statin re-challenge by Elam, Marshall B, Majumdar, Gipsy, Mozhui, Khyobeni, Gerling, Ivan C, Vera, Santiago R, Fish-Trotter, Hannah, Williams, Robert W, Childress, Richard D, Raghow, Rajendra

“…Statins, the 3-hydroxy-3-methyl-glutaryl (HMG)-CoA reductase inhibitors, are widely prescribed for treatment of hypercholesterolemia. Although statins are…”
Get full text

Insulin Enhances the Biogenesis of Nuclear Sterol Regulatory Element-binding Protein (SREBP)-1c by Posttranscriptional Down-regulation of Insig-2A and Its Dissociation from SREBP Cleavage-activating Protein (SCAP)·SREBP-1c Complex by Yellaturu, Chandrahasa R., Deng, Xiong, Park, Edwards A., Raghow, Rajendra, Elam, Marshall B.

“…The regulation of lipid homeostasis by insulin is mediated in part by the enhanced transcription of the gene encoding sterol regulatory element-binding…”
Get full text

Pan-histone deacetylase inhibitors regulate signaling pathways involved in proliferative and pro-inflammatory mechanisms in H9c2 cells by Majumdar, Gipsy, Adris, Piyatilake, Bhargava, Neha, Chen, Hao, Raghow, Rajendra

“…We have shown previously that pan-HDAC inhibitors (HDACIs) m-carboxycinnamic acid bis-hydroxamide (CBHA) and trichostatin A (TSA) attenuated cardiac…”
Get full text

Metabolic balancing acts of vitamin A in type-2 diabetes and obesity by Raghow, Rajendra

“…Using mice that lack retinaldehyde dehydrogenase 1 gene(Raldh1-/-mice),Kierfer et al demonstrated that retinoids(metabolites of Vitamin A) play an important…”
Get full text

A streamlined protocol for extracting RNA and genomic DNA from archived human blood and muscle by Majumdar, Gipsy, Vera, Santiago, Elam, Marshall B., Raghow, Rajendra

“…We combined the TRIzol method of nucleic acid extraction with QIAamp columns to achieve coextraction of RNA and genomic DNA from peripheral blood mononuclear…”
Get full text

Insulin Enhances Post-translational Processing of Nascent SREBP-1c by Promoting Its Phosphorylation and Association with COPII Vesicles by Yellaturu, Chandrahasa R., Deng, Xiong, Cagen, Lauren M., Wilcox, Henry G., Mansbach, Charles M., Siddiqi, Shadab A., Park, Edwards A., Raghow, Rajendra, Elam, Marshall B.

“…The regulation of lipid homeostasis by insulin is mediated in part by the enhanced transcription of the gene encoding SREBP-1c (sterol regulatory…”
Get full text

Gestational nutrition and the development of obesity during adulthood by Raghow, Rajendra

“…Recent epidemiological studies indicate a strong linkbetween intrauterine under-nutrition and propensityof such off spring for developing obesity and…”
Get full text

Functional Consequences of Interactions between Pax9 and Msx1 Genes in Normal and Abnormal Tooth Development by Ogawa, Takuya, Kapadia, Hitesh, Feng, Jian Q., Raghow, Rajendra, Peters, Heiko, D'Souza, Rena N.

“…Pax9 and Msx1 encode transcription factors that are known to be essential for the switch in odontogenic potential from the epithelium to the mesenchyme…”
Get full text

Phosphorylation of sterol regulatory element binding protein-1a by protein kinase A (PKA) regulates transcriptional activity by Dong, Qingming, Giorgianni, Francesco, Deng, Xiong, Beranova-Giorgianni, Sarka, Bridges, Dave, Park, Edwards A., Raghow, Rajendra, Elam, Marshall B.

“…•Phosphorylation of SREBP-1 regulates its processing and transcriptional activity.•PKA mediates the effects of glucagon and cAMP by downregulating SREBP-1…”
Get full text

An ‘Omics’ Perspective on Cardiomyopathies and Heart Failure by Raghow, Rajendra

“…Pathological enlargement of the heart, represented by hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM), occurs in response to many genetic…”
Get full text