Search Results - "Rajchman, Dana"
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The extracellular matrix protein agrin promotes heart regeneration in mice
Published in Nature (London) (13-07-2017)“…The adult mammalian heart is non-regenerative owing to the post-mitotic nature of cardiomyocytes. The neonatal mouse heart can regenerate, but only during the…”
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Reduced matrix rigidity promotes neonatal cardiomyocyte dedifferentiation, proliferation and clonal expansion
Published in eLife (12-08-2015)“…Cardiomyocyte (CM) maturation in mammals is accompanied by a sharp decline in their proliferative and regenerative potential shortly after birth. In this…”
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ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation
Published in Nature cell biology (01-05-2015)“…The murine neonatal heart can regenerate after injury through cardiomyocyte (CM) proliferation, although this capacity markedly diminishes after the first week…”
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A new immunization and treatment strategy for mouse mammary tumor virus (MMTV) associated cancers
Published in Oncotarget (19-04-2016)“…Mouse Mammary Tumor Virus (MMTV) causes mammary carcinoma or lymphoma in mice. An increasing body of evidence in recent years supports its involvement also in…”
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The small molecule Chicago Sky Blue promotes heart repair following myocardial infarction in mice
Published in JCI insight (14-11-2019)“…The adult mammalian heart regenerates poorly after injury and, as a result, ischemic heart diseases are among the leading causes of death worldwide. The…”
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Abstract A109: A signal peptide as a putative tool against MMTV-associated breast cancers
Published in Molecular cancer research (01-10-2013)“…Abstract Mouse Mammary Tumor Virus (MMTV) causes mammary carcinoma and lymphoma in mice. An increasing body of evidence from different laboratories suggests an…”
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