Search Results - "Rajbhandari, Rajani"

PERK-Dependent Activation of JAK1 and STAT3 Contributes to Endoplasmic Reticulum Stress-Induced Inflammation by Meares, Gordon P., Liu, Yudong, Rajbhandari, Rajani, Qin, Hongwei, Nozell, Susan E., Mobley, James A., Corbett, John A., Benveniste, Etty N.

“…Neuroinflammation and endoplasmic reticulum (ER) stress are associated with many neurological diseases. Here, we have examined the interaction between ER…”
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Attenuation of PKR-like ER Kinase (PERK) Signaling Selectively Controls Endoplasmic Reticulum Stress-induced Inflammation Without Compromising Immunological Responses by Guthrie, Lauren N., Abiraman, Kavitha, Plyler, Emily S., Sprenkle, Neil T., Gibson, Sara A., McFarland, Braden C., Rajbhandari, Rajani, Rowse, Amber L., Benveniste, Etty N., Meares, Gordon P.

“…Inflammation and endoplasmic reticulum (ER) stress are associated with many neurological diseases. ER stress is brought on by the accumulation of misfolded…”
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NF-κB-induced IL-6 ensures STAT3 activation and tumor aggressiveness in glioblastoma by McFarland, Braden C, Hong, Suk W, Rajbhandari, Rajani, Twitty, Jr, George B, Gray, G Kenneth, Yu, Hao, Benveniste, Etty N, Nozell, Susan E

“…Glioblastoma (GBM) is the most aggressive, neurologically destructive and deadly tumor of the central nervous system (CNS). In GBM, the transcription factors…”
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Let-7 Status Is Crucial for PARP1 Expression in HER2-Overexpressing Breast Tumors by Wielgos, Monica E, Rajbhandari, Rajani, Cooper, Tiffiny S, Wei, Shi, Nozell, Susan, Yang, Eddy S

“…HER2 breast tumors have been shown to express elevated levels of PARP1 protein. Yet, the mechanism by which PARP1 is upregulated in HER2 breast cancer is…”
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Novel EGFR ectodomain mutations associated with ligand-independent activation and cetuximab resistance in head and neck cancer by Nair, Sindhu, Trummell, Hoa Q, Rajbhandari, Rajani, Thudi, Nanda K, Nozell, Susan E, Warram, Jason M, Willey, Christopher D, Yang, Eddy S, Placzek, William J, Bonner, James A, Bredel, Markus

“…Epidermal growth factor receptor (EGFR) is a pro-tumorigenic receptor tyrosine kinase that facilitates growth for cancer cells that overexpress the receptor…”
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The Chinese Pueraria root extract (Pueraria lobata) ameliorates impaired glucose and lipid metabolism in obese mice by Prasain, Jeevan K., Peng, Ning, Rajbhandari, Rajani, Wyss, J. Michael

“…The incidence of type 2 diabetes and metabolic disease is rapidly increasing, but effective therapies for their prevention and treatment have been poorly…”
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Trastuzumab-Resistant HER2 + Breast Cancer Cells Retain Sensitivity to Poly (ADP-Ribose) Polymerase (PARP) Inhibition by Wielgos, Monica E, Zhang, Zhuo, Rajbhandari, Rajani, Cooper, Tiffiny S, Zeng, Ling, Forero, Andres, Esteva, Francisco J, Osborne, C Kent, Schiff, Rachel, LoBuglio, Albert F, Nozell, Susan E, Yang, Eddy S

“…HER2-targeted therapies, such as trastuzumab, have increased the survival rates of HER2 breast cancer patients. However, despite these therapies, many tumors…”
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MicroRNA‐31 is required for astrocyte specification by Meares, Gordon P., Rajbhandari, Rajani, Gerigk, Magda, Tien, Chih‐Liang, Chang, Chenbei, Fehling, Samuel C., Rowse, Amber, Mulhern, Kayln C., Nair, Sindhu, Gray, G. Kenneth, Berbari, Nicolas F., Bredel, Markus, Benveniste, Etty N., Nozell, Susan E.

“…Previously, we determined microRNA‐31 (miR‐31) is a noncoding tumor suppressive gene frequently deleted in glioblastoma (GBM); miR‐31 suppresses tumor growth,…”
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CSIG-31. ANNEXIN A7 ALTERNATIVE SPLICING IN GLIOMA STEM CELLS FACILITATES THE DEGRADATION OF EGFR BY PHOSPHORYLATING TYROSINE RESIDUES EXCLUSIVE TO PROTEIN ISOFORM 1 by Merati, Aran, Nair, Sindhu, Rajbhandari, Rajani, Johnson, Nicholas, Bredel, Markus

“…Abstract The majority of GBMs express aberrant receptor tyrosine kinase (RTK) activity, which are canonically endocytosed and degraded. This process is…”
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Abstract 2445: Alternative splicing dictates receptor tyrosine kinase fates in glioblastoma by Nair, Sindhu, Rajbhandari, Rajani, Hurt, Centdrika, Bredel, Markus

“…Abstract Receptor tyrosine kinase (RTK) genes are frequently amplified and/or overexpressed in glioblastoma (GBM). RTK signaling can undergo two fates -…”
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COVID-19 in Patients with Multiple Sclerosis: Associations with Disease-Modifying Therapies by Reder, Anthony T., Centonze, Diego, Naylor, Maria L., Nagpal, Anjali, Rajbhandari, Rajani, Altincatal, Arman, Kim, Michelle, Berdofe, Aaron, Radhakrishnan, Maha, Jung, Eunice, Sandrock, Alfred W., Smirnakis, Karen, Popescu, Catrinel, de Moor, Carl

“…Background Disease-modifying therapies (DMTs) for multiple sclerosis (MS) target immunity and have the potential to increase the risk of severe acute…”
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Abstract 3747: Dysregulated splicing of Annexin A7 impairs receptor tyrosine kinase trafficking in glioblastoma by Nair, Sindhu, Rajbhandari, Rajani, Dates-Hurt, Centdrika, Bredel, Markus

“…Abstract Alternative splicing (AS), a tightly regulated process, contributes to proteome diversification essential for tissue development and identity. During…”
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A Retrospective Chart Review of Lymphocyte Reconstitution Among MS Patients After Discontinuation of Dimethyl Fumarate (2040) by Newman, Stephen, Scott, Nicole, Collins, Auston, Bohn, Justin, Rajbhandari, Rajani, Kapadia, Shivani, Harding, Tiffany

“…Abstract only…”
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Abstract 3003: Exon skipping for the tumor suppressor Annexin A7 promotes EGFR signaling in stem-like brain tumor initiating cells through receptor recycling by Merati, Aran, Nair, Sindhu, Rajbhandari, Rajani, Johnson, Nicholas, Bredel, Markus

“…Abstract Background: Glioblastoma (GBM) is one of the most lethal forms of cancer. The majority of GBMs express aberrant receptor tyrosine kinase (RTK)…”
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Abstract 3758: Impact of ANXA7 I1 expression on PDGFRA and MET endosomal trafficking in glioblastoma by White, Zachary B., Hurt, Centdrika Dates, Rajbhandari, Rajani, Nair, Sindhu, Nozell, Susan, Bredel, Markus

“…Abstract Purpose/Objective(s): Glioblastomas (GBM) are highly malignant tumors that arise from astrocytes. GBMs rely on signaling through receptor tyrosine…”
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Withaferin A and sulforaphane regulate breast cancer cell cycle progression through epigenetic mechanisms by Royston, Kendra J., Paul, Bidisha, Nozell, Susan, Rajbhandari, Rajani, Tollefsbol, Trygve O.

“…Little is known about the effects of combinatorial dietary compounds on the regulation of epigenetic mechanisms involved in breast cancer prevention. The human…”
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CSIG-12. ANNEXIN A7 ISOFORMS DIFFERENTIALLY REGULATE TUMORIGENIC EGFR SIGNALING IN GLIOBLASTOMA MULTIFORME by Nair, Sindhu, Nozell, Susan, Hurt, Centdrika, Rajbhandari, Rajani, Bredel, Markus

“…Abstract Dysregulation of receptor tyrosine kinase genes is a frequent genetic abnormality in GBM. A common genetic alteration is amplification and/or…”
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STAT4 controls GM-CSF production by both Th1 and Th17 cells during EAE by McWilliams, Ian L, Rajbhandari, Rajani, Nozell, Susan, Benveniste, Etty, Harrington, Laurie E

“…In experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis, mice genetically deficient in the transcription factor signal…”
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Abstract 471: HER2 regulates PARP-1 expression by suppressing the let-7a microRNA in HER2+ breast cancer by Yang, Eddy Shih-Hsin, Wielgos, Monicka, Rajbhandari, Rajani, Wei, Shi, Nozell, Susan

“…Abstract Background: HER2+ breast cancers are sensitive to PARP inhibition and express elevated levels of the PARP-1 protein. However, the mode of regulation…”
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STAT4 controls GM-CSF production by both Th1 and Th17 cells during EAE (BA4P.140) by Harrington, Laurie, Nozell, Susan, Rajbhandari, Rajani, Benveniste, Etty, McWilliams, Ian

“…Abstract Factors mediating Th1 and Th17 CD4 T cell driven autoimmunity remain unclear. In the mouse model of Multiple Sclerosis, experimental autoimmune…”
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