Search Results - "Rajasimha, Harsha K"

Cross-border rare disease advocacy: Preethi Krishnaraj interviews Harsha Rajasimha by Krishnaraj, Preethi, Rajasimha, Harsha K

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Non-random mtDNA segregation patterns indicate a metastable heteroplasmic segregation unit in m.3243A>G cybrid cells by Raap, Anton K, Jahangir Tafrechi, Roshan S, van de Rijke, Frans M, Pyle, Angela, Wählby, Carolina, Szuhai, Karoly, Ravelli, Raimond B G, de Coo, René F M, Rajasimha, Harsha K, Nilsson, Mats, Chinnery, Patrick F, Samuels, David C, Janssen, George M C

“…Many pathogenic mitochondrial DNA mutations are heteroplasmic, with a mixture of mutated and wild-type mtDNA present within individual cells. The severity and…”
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Developing Rods Transplanted into the Degenerating Retina of Crx‐Knockout Mice Exhibit Neural Activity Similar to Native Photoreceptors by Homma, Kohei, Okamoto, Satoshi, Mandai, Michiko, Gotoh, Norimoto, Rajasimha, Harsha K., Chang, Yi‐Sheng, Chen, Shan, Li, Wei, Cogliati, Tiziana, Swaroop, Anand, Takahashi, Masayo

“…Replacement of dysfunctional or dying photoreceptors offers a promising approach for retinal neurodegenerative diseases, including age‐related macular…”
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Next-generation sequencing facilitates quantitative analysis of wild-type and Nrl(-/-) retinal transcriptomes by Brooks, Matthew J, Rajasimha, Harsha K, Roger, Jerome E, Swaroop, Anand

“…Next-generation sequencing (NGS) has revolutionized systems-based analysis of cellular pathways. The goals of this study are to compare NGS-derived retinal…”
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Differential gene expression and alternative splicing between diploid and tetraploid watermelon by Saminathan, Thangasamy, Nimmakayala, Padma, Manohar, Sumanth, Malkaram, Sridhar, Almeida, Aldo, Cantrell, Robert, Tomason, Yan, Abburi, Lavanya, Rahman, Mohammad A., Vajja, Venkata G., Khachane, Amit, Kumar, Brajendra, Rajasimha, Harsha K., Levi, Amnon, Wehner, Todd, Reddy, Umesh K.

“…The exploitation of synthetic polyploids for producing seedless fruits is well known in watermelon. Tetraploid progenitors of triploid watermelon plants,…”
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Building cross-border collaborations to increase diversity and accelerate rare disease drug development – meeting report from the inaugural IndoUSrare Annual Conference 2021 by Khera, Harvinder Kour, Venugopal, Nisha, Karur, Ramya T., Mishra, Rakesh, Kartha, Reena V., Rajasimha, Harsha K.

“…The inaugural IndoUSrare Annual Conference was held virtually from 29 November to 2 December 2021 and was organized by the Indo US Organization for Rare…”
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Transcriptome analysis using next generation sequencing reveals molecular signatures of diabetic retinopathy and efficacy of candidate drugs by Kandpal, Raj P, Rajasimha, Harsha K, Brooks, Matthew J, Nellissery, Jacob, Wan, Jun, Qian, Jiang, Kern, Timothy S, Swaroop, Anand

“…To define gene expression changes associated with diabetic retinopathy in a mouse model using next generation sequencing, and to utilize transcriptome…”
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The future of clinical trials: more transparency and pharmacogenomics by Rajasimha, Harsha K

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AB133. SmartLabs—a solution to healthcare by Elackatt, Niby J., Rajasimha, Harsha K.

“…DNA sequencing is the most commonly used approach for mutation scanning and is widely regarded as the gold standard in diagnostics of rare diseases. Genetic…”
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Non-Random mtDNA Segregation Patterns Indicate a Metastable Heteroplasmic Segregation Unit in m.3243AG Cybrid Cells by Raap, Anton K, Jahangir Tafrechi, Roshan S, van de Rijke, Frans M, Pyle, Angela, Wählby, Carolina, Szuhai, Karoly, Ravelli, Raimond B. G, de Coo, René F. M, Rajasimha, Harsha K, Nilsson, Mats, Chinnery, Patrick F, Samuels, David C, Janssen, George M. C

“…Many pathogenic mitochondrial DNA mutations are heteroplasmic, with a mixture of mutated and wild-type mtDNA present within individual cells. The severity and…”
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A simulation methodology in modeling cell divions with stochastic effects by RAJASIMHA, Harsha K, SAMUELS, David C, NANCE, Richard E

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A simulation methodology in modeling cell divisions with stochastic effects by Rajasimha, Harsha K., Samuels, David C., Nance, Richard E.

“…We present a model to explain the effects of the long time between blood stem cell divisions and rapid cascades of progenitor cell divisions on the…”
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