Search Results - "Rajashankar, K. R."

Structural differences between the Streptococcus agalactiae housekeeping and pilus-specific sortases: SrtA and SrtC1 by Khare, B, Krishnan, V, Rajashankar, K R, I-Hsiu, H, Xin, M, Ton-That, H, Narayana, S V

“…The assembly of pili on the cell wall of Gram-positive bacteria requires transpeptidase enzymes called sortases. In Streptococcus agalactiae, the PI-1 pilus…”
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Novel approach to phasing proteins: derivatization by short cryo-soaking with halides by Dauter, Zbigniew, Dauter, Miroslawa, Rajashankar, K. R.

“…A quick (less than 1 min) soak of protein crystals in a cryo‐solution containing bromide or iodide anions leads to incorporation of these anomalous scatterers…”
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Crystal structure of human intrinsic factor: Cobalamin complex at 2.6-Å resolution by Mathews, F.S, Gordon, M.M, Chen, Z, Rajashankar, K.R, Ealick, S.E, Alpers, D.H, Sukumar, N

“…The structure of intrinsic factor (IF) in complex with cobalamin (Cbl) was determined at 2.6-Å resolution. The overall fold of the molecule is that of an α₆/α₆…”
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The Structure of Human β-Defensin-2 Shows Evidence of Higher Order Oligomerization by Hoover, David M., Rajashankar, Kanaghalagatta R., Blumenthal, Robert, Puri, Anu, Oppenheim, Joost J., Chertov, Oleg, Lubkowski, Jacek

“…Defensins are small cationic peptides that are crucial components of innate immunity, serving as both antimicrobial agents and chemoattractant molecules. The…”
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Structure, mechanism and engineering of a nucleotidylyltransferase as a first step toward glycorandomization by Thorson, Jon S, Nikolov, Dimitar B, Barton, William A, Lesniak, Jacob, Biggins, John B, Jeffrey, Philip D, Jiang, Jiqing, Rajashankar, K. R

“…Metabolite glycosylation is affected by three classes of enzymes: nucleotidylyltransferases, which activate sugars as nucleotide diphospho-derivatives,…”
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Structure of human phosphatidylcholine transfer protein in complex with its ligand by Roderick, Steven L, Cohen, David E, Chan, Wayne W, Agate, Diana S, Olsen, Laurence R, Vetting, Matt W, Rajashankar, K.R

“…Phosphatidylcholines (PtdChos) comprise the most common phospholipid class in eukaryotic cells. In mammalian cells, these insoluble molecules are transferred…”
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A Novel Mode of Gleevec Binding Is Revealed by the Structure of Spleen Tyrosine Kinase by Atwell, Shane, Adams, Jason M., Badger, John, Buchanan, Michelle D., Feil, Ingeborg K., Froning, Karen J., Gao, Xia, Hendle, Jörg, Keegan, Kevin, Leon, Barbara C., Müller-Dieckmann, Hans J., Nienaber, Vicki L., Noland, Brian W., Post, Kai, Rajashankar, K.R., Ramos, Aurora, Russell, Marijane, Burley, Stephen K., Buchanan, Sean G.

“…Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase required for signaling from immunoreceptors in various hematopoietic cells. Phosphorylation of…”
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Recognition of the Rotavirus mRNA 3′ Consensus by an Asymmetric NSP3 Homodimer by Deo, Rahul C., Groft, Caroline M., Rajashankar, K.R., Burley, Stephen K.

“…Rotaviruses, the cause of life-threatening diarrhea in humans and cattle, utilize a functional homolog of poly(A) binding protein (PABP) known as nonstructural…”
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Crystal Structure of a Light-Harvesting Protein C-Phycocyanin from Spirulina platensis by Padyana, Anil K., Bhat, Vadiraja B., Madyastha, K.M., Rajashankar, K.R., Ramakumar, S.

“…The crystal structure of C-phycocyanin, a light-harvesting phycobiliprotein from cyanobacteria (blue-green algae) Spirulina platensis has been solved by…”
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Cocrystal Structures of Diaminopimelate Decarboxylase: Mechanism, Evolution, and Inhibition of an Antibiotic Resistance Accessory Factor by Ray, Soumya S., Bonanno, Jeffrey B., Rajashankar, K.R., Pinho, Mariana G., He, Guoshun, De Lencastre, Herminia, Tomasz, Alexander, Burley, Stephen K.

“…Cocrystal structures of Methanococcus jannaschii diaminopimelate decarboxylase (DAPDC) bound to a substrate analog, azelaic acid, and its L-lysine product have…”
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π‐Turns in proteins and peptides: Classification, conformation, occurrence, hydration and sequence by Rajashankar, K.R., Ramakumar, S.

“…The i + 5 → i hydrogen bonded turn conformation (7r‐turn) with the fifth residue adopting αL conformation is frequently found at the C‐terminus of helices in…”
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Crystal structure of an Eph receptor-ephrin complex by Nikolov, Dimitar B, Himanen, Juha-Pekka, Rajashankar, Kanagalaghatta R, Lackmann, Martin, Cowan, Chad A, Henkemeyer, Mark

“…The Eph family of receptor tyrosine kinases and their membrane-anchored ephrin ligands are important in regulating cell-cell interactions as they initiate a…”
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Structure of the Semaphorin-3A Receptor Binding Module by Antipenko, Alexander, Himanen, Juha-Pekka, van Leyen, Klaus, Nardi-Dei, Vincenzo, Lesniak, Jacob, Barton, William A., Rajashankar, Kanagalaghatta R., Lu, Min, Hoemme, Claudia, Püschel, Andreas W., Nikolov, Dimitar B.

“…The semaphorins are a large group of extracellular proteins involved in a variety of processes during development, including neuronal migration and axon…”
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Observation of Water-Mediated Helix-Terminating Conformation in a Dehydrophenylalanine Peptide: Crystal and Solution Structure of the Octapeptide Ac-.DELTA.Phe-Val-.DELTA.Phe-Phe-Ala-Val-.DELTA.Phe-Gly-OMe by Rajashankar, K. R, Ramakumar, S, Jain, R. M, Chauhan, V. S

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Structure of mare apolactoferrin: the N and C lobes are in the closed form by Sharma, A. K., Rajashankar, K. R., Yadav, M. P., Singh, T. P.

“…The structure of mare apolactoferrin (MALT) has been determined at 3.8 Å resolution by the molecular‐replacement method, using the structure of mare diferric…”
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Modulation of phospholipase A2 activity generated by molecular evolution by Betzel, C, Genov, N, Rajashankar, K R, Singh, T P

“…Snake venom oligomeric neurotoxins offer several unique examples of modulation of phospholipase A2 (PLA2) activity generated by molecular evolution. This…”
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First Observation of Left-Handed Helical Conformation in a Dehydro Peptide Containing Two l-Val Residues. Crystal and Solution Structure of Boc-l-Val-ΔPhe-ΔPhe-ΔPhe-l-Val-OMe by Jain, R. M, Rajashankar, K. R, Ramakumar, S, Chauhan, V. S

“…The solution and solid structure of Boc-l-Val-ΔPhe-ΔPhe-ΔPhe-l-Val-OMe, containing three consecutive ΔPhe residues, have been determined by X-ray diffraction,…”
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Preliminary crystallographic study of the Streptococcus agalactiae sortases, sortase A and sortase C1 by Khare, Baldeep, Samal, Alexandra, Vengadesan, Krishnan, Rajashankar, K. R., Ma, Xin, Huang, I-Hsiu, Ton-That, Hung, Narayana, Sthanam V. L.

“…Sortases are cysteine transpeptidases that are essential for the assembly and anchoring of cell‐surface adhesins in Gram‐positive bacteria. In Streptococcus…”
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Preliminary X-ray diffraction studies of the external functional unit RtH2-e from the Rapana thomasiana by Perbandt, M., Chandra, V., Rajashankar, K. R., Idakieva, K., Parvanova, K., Rypniewski, W., Stoeva, S., Voelter, W., Genov, N., Betzel, Ch

“…The `external' oxygenated functional unit RtH2‐e of the Rapana hemocyanin subunit RHSS2 was isolated and crystallized. X‐ray intensity data to 3.3 Å resolution…”
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Modulation of phospholipase A 2 activity generated by molecular evolution by Betzel, C., Genov, N., Rajashankar, K. R., Singh, T. P.

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