Search Results - "Rajasekhar, K"

Current progress, challenges and future prospects of diagnostic and therapeutic interventions in Alzheimer's disease by Rajasekhar, K, Govindaraju, Thimmaiah

“…Alzheimer's disease (AD) is the most prevalent, progressive and multifaceted neurodegenerative disorder associated with cognition, memory and behavioural…”
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Function and toxicity of amyloid beta and recent therapeutic interventions targeting amyloid beta in Alzheimer's disease by Rajasekhar, K, Chakrabarti, Malabika, Govindaraju, T

“…Amyloidogenesis has been implicated in a broad spectrum of diseases in which amyloid protein is invariably misfolded and deposited in cells and organs…”
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L1-Norm and LMS Based Digital FIR Filters Design Using Evolutionary Algorithms by Rajasekhar, K.

“…The suggested work in this paper involves the construction of digital filters by utilizing optimization algorithms to compute optimum filter coefficients in…”
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Natural Tripeptide-Based Inhibitor of Multifaceted Amyloid β Toxicity by Rajasekhar, K, Madhu, Chilakapati, Govindaraju, T

“…Accumulation of amyloid beta (Aβ) peptide and its aggregates in the human brain is considered as one of the hallmarks of Alzheimer’s disease (AD). The…”
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Hybrid Multifunctional Modulators Inhibit Multifaceted Aβ Toxicity and Prevent Mitochondrial Damage by Rajasekhar, K, Mehta, Kapilkumar, Govindaraju, Thimmaiah

“…Amyloid beta (Aβ) aggregation is the key trait responsible for the pathological devastation caused by Alzheimer’s disease (AD). Among the various pathways of…”
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Cyclic dipeptide based cell-penetrating peptidomimetics for effective DNA delivery by Madhu, Chilakapati, Voshavar, Chandrashekhar, Rajasekhar, K, Govindaraju, Thimmaiah

“…An unnatural CDP-amino acid (kd) is used in the design and synthesis of novel cell penetrating peptidomimetic (Kkd-5). The balanced cationic nature and…”
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Rationally Designed Peptidomimetic Modulators of Aβ Toxicity in Alzheimer's Disease by Rajasekhar, K., Suresh, S. N., Manjithaya, Ravi, Govindaraju, T.

“…Alzheimer's disease is one of the devastating illnesses mankind is facing in the 21 st century. The main pathogenic event in Alzheimer's disease is believed to…”
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Secure Routing in MANETS Using Adaptive Cuckoo Search and Entropy Based Signature Authentication by Aluvala, Srinivas, Rajasekhar, K.

“…MANET (Mobile Ad hoc Network) is a collection of self-organizing mobile nodes that operate independently of centralized administration or existing…”
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Aβ plaque-selective NIR fluorescence probe to differentiate Alzheimer's disease from tauopathies by Rajasekhar, K., Narayanaswamy, Nagarjun, Murugan, N. Arul, Viccaro, Keith, Lee, Hyoung-Gon, Shah, Kavita, Govindaraju, Thimmaiah

“…Selective detection and staining of toxic amyloid plaques, a potential biomarker present in the Alzheimer's disease (AD) brain is crucial for both clinical…”
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Cu2+-modified physical properties of Cobalt-Nickel ferrite by Rajasekhar Babu, K., Rao, K. Rama, Rajesh Babu, B.

“…•In this work, Influence of Cu and cation redistribution is discussed in detail.•Theoretical and experimental results related to distribution, lattice constant…”
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A High Affinity Red Fluorescence and Colorimetric Probe for Amyloid β Aggregates by Rajasekhar, K., Narayanaswamy, Nagarjun, Murugan, N. Arul, Kuang, Guanglin, Ågren, Hans, Govindaraju, T.

“…A major challenge in the Alzheimer’s disease (AD) is its timely diagnosis. Amyloid β (Aβ) aggregates have been proposed as the most viable biomarker for the…”
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Concise Review: Roles of Polycomb Group Proteins in Development and Disease: A Stem Cell Perspective by Rajasekhar, Vinagolu K., Begemann, Martin

“…The acquisition and maintenance of cell fate are essential for metazoan growth and development. A strict coordination between genetic and epigenetic programs…”
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Tumour-specific PI3K inhibition via nanoparticle-targeted delivery in head and neck squamous cell carcinoma by Mizrachi, Aviram, Shamay, Yosi, Shah, Janki, Brook, Samuel, Soong, Joanne, Rajasekhar, Vinagolu K., Humm, John L., Healey, John H., Powell, Simon N., Baselga, José, Heller, Daniel A., Haimovitz-Friedman, Adriana, Scaltriti, Maurizio

“…Alterations in PIK3CA , the gene encoding the p110α subunit of phosphatidylinositol 3-kinase (PI3Kα), are frequent in head and neck squamous cell carcinomas…”
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Study of charge transfer mechanism of PEDOT polymer for detection of solid TEX and CL-20 explosives using pulsed photoacoustic technique by Kumari, Archana, Chaudhary, A.K., Rajasekhar, K.

“…We report the use of PEDOT polymer (poly (2, 3-dihydrothieno [3,4-b] dioxane-5,7-diyl) as a sensing medium for the detection of solid secondary explosives like…”
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Evolution of Cancer Stem-like Cells in Endocrine-Resistant Metastatic Breast Cancers Is Mediated by Stromal Microvesicles by Sansone, Pasquale, Berishaj, Marjan, Rajasekhar, Vinagolu K, Ceccarelli, Claudio, Chang, Qing, Strillacci, Antonio, Savini, Claudia, Shapiro, Lauren, Bowman, Robert L, Mastroleo, Chiara, De Carolis, Sabrina, Daly, Laura, Benito-Martin, Alberto, Perna, Fabiana, Fabbri, Nicola, Healey, John H, Spisni, Enzo, Cricca, Monica, Lyden, David, Bonafé, Massimiliano, Bromberg, Jacqueline

“…The hypothesis that microvesicle-mediated miRNA transfer converts noncancer stem cells into cancer stem cells (CSC) leading to therapy resistance remains…”
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Indirect Discretization Based Design of Fractional Order Differintegrators at Various Sampling Intervals and Its Application to Edge Detection by Rajasekhar, K., Krishna, B. T.

“…The main objective of this paper is the design of digital differentiators and integrators of various Fractional orders i.e α = 1 / 2 , 1 / 3 , 1 / 4 at…”
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Design and performance analysis of ohmic contact based SPMT RF MEMS switch by Rajasekhar, K., GirijaSravani, K., Srinivasa Rao, K.

“…RF signal routers are become prominent in the modern wireless communication transceivers. SPMT RF MEMS switches predominantly plays significant role in RF…”
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Epigenetic activation of a subset of mRNAs by eIF4E explains its effects on cell proliferation by Mamane, Yaël, Petroulakis, Emmanuel, Martineau, Yvan, Sato, Taka-Aki, Larsson, Ola, Rajasekhar, Vinagolu K, Sonenberg, Nahum

“…Translation deregulation is an important mechanism that causes aberrant cell growth, proliferation and survival. eIF4E, the mRNA 5' cap-binding protein, plays…”
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Self-renewal of CD133hi cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer by Sansone, Pasquale, Ceccarelli, Claudio, Berishaj, Marjan, Chang, Qing, Rajasekhar, Vinagolu K., Perna, Fabiana, Bowman, Robert L., Vidone, Michele, Daly, Laura, Nnoli, Jennifer, Santini, Donatella, Taffurelli, Mario, Shih, Natalie N. C., Feldman, Michael, Mao, Jun J., Colameco , Christopher, Chen, Jinbo, DeMichele, Angela, Fabbri, Nicola, Healey, John H., Cricca, Monica, Gasparre, Giuseppe, Lyden, David, Bonafé, Massimiliano, Bromberg, Jacqueline

“…The mechanisms of metastatic progression from hormonal therapy (HT) are largely unknown in luminal breast cancer. Here we demonstrate the enrichment of CD133…”
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Crizotinib, a c-Met inhibitor, prevents metastasis in a metastatic uveal melanoma model by Surriga, Oliver, Rajasekhar, Vinagolu K, Ambrosini, Grazia, Dogan, Yildrim, Huang, Ruimin, Schwartz, Gary K

“…Uveal melanoma is the most common primary intraocular malignant tumor in adults and half of the primary tumors will develop fatal metastatic disease to the…”
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