Search Results - "Rajasekaran, Namakkal S."

KEAP1-NRF2 signalling and autophagy in protection against oxidative and reductive proteotoxicity by Dodson, Matthew, Redmann, Matthew, Rajasekaran, Namakkal S, Darley-Usmar, Victor, Zhang, Jianhua

“…Maintaining cellular redox status to allow cell signalling to occur requires modulation of both the controlled production of oxidants and the thiol-reducing…”
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Exercise, Nrf2 and Antioxidant Signaling in Cardiac Aging by Narasimhan, Madhusudhanan, Rajasekaran, Namakkal S

“…Aging is represented by a progressive decline in cellular functions. The age-related deformities in cardiac behaviors are the loss of cardiac myocytes through…”
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Heme-Mediated SPI-C Induction Promotes Monocyte Differentiation into Iron-Recycling Macrophages by Haldar, Malay, Kohyama, Masako, So, Alex Yick-Lun, KC, Wumesh, Wu, Xiaodi, Briseño, Carlos G., Satpathy, Ansuman T., Kretzer, Nicole M., Arase, Hisashi, Rajasekaran, Namakkal S., Wang, Li, Egawa, Takeshi, Igarashi, Kazuhiko, Baltimore, David, Murphy, Theresa L., Murphy, Kenneth M.

“…Splenic red pulp macrophages (RPM) degrade senescent erythrocytes and recycle heme-associated iron. The transcription factor SPI-C is selectively expressed by…”
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Reductive potential — A savior turns stressor in protein aggregation cardiomyopathy by Narasimhan, Madhusudhanan, Rajasekaran, Namakkal S.

“…Redox homeostasis is essential for basal signaling of several physiological processes, but a unilateral shift towards an ‘oxidative’ or ‘reductive’ trait will…”
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Impaired transcriptional activity of Nrf2 in age-related myocardial oxidative stress is reversible by moderate exercise training by Gounder, Sellamuthu S, Kannan, Sankaranarayanan, Devadoss, Dinesh, Miller, Corey J, Whitehead, Kevin J, Whitehead, Kevin S, Odelberg, Shannon J, Firpo, Matthew A, Paine, 3rd, Robert, Hoidal, John R, Abel, E Dale, Rajasekaran, Namakkal S

“…Aging promotes accumulation of reactive oxygen/nitrogen species (ROS/RNS) in cardiomyocytes, which leads to contractile dysfunction and cardiac abnormalities…”
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Reductive stress impairs myogenic differentiation by Rajasekaran, Namakkal S., Shelar, Sandeep Balu, Jones, Dean P., Hoidal, John R.

“…Myo-satellite cells regenerate and differentiate into skeletal muscle (SM) after acute or chronic injury. Changes in the redox milieu towards the oxidative arm…”
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Constitutive activation of Nrf2 induces a stable reductive state in the mouse myocardium by Shanmugam, Gobinath, Narasimhan, Madhusudhanan, Tamowski, Susan, Darley-Usmar, Victor, Rajasekaran, Namakkal S

“…Redox homeostasis regulates key cellular signaling pathways in both physiology and pathology. The cell's antioxidant response provides a defense against…”
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Redox biology and the interface between bioenergetics, autophagy and circadian control of metabolism by Wende, Adam R., Young, Martin E., Chatham, John, Zhang, Jianhua, Rajasekaran, Namakkal S., Darley-Usmar, Victor M.

“…Understanding molecular mechanisms that underlie the recent emergence of metabolic diseases such as diabetes and heart failure has revealed the need for a…”
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Blueberry Metabolites Attenuate Lipotoxicity‐Induced Endothelial Dysfunction by Bharat, Divya, Cavalcanti, Rafaela Ramos Mororo, Petersen, Chrissa, Begaye, Nathan, Cutler, Brett Ronald, Costa, Marcella Melo Assis, Ramos, Renata Kelly Luna Gomes, Ferreira, Marina Ramos, Li, Youyou, Bharath, Leena P., Toolson, Emma, Sebahar, Paul, Looper, Ryan E., Jalili, Thunder, Rajasekaran, Namakkal S., Jia, Zhenquan, Symons, J. David, Anandh Babu, Pon Velayutham

“…Scope Lipotoxicity‐induced endothelial dysfunction is an important vascular complication associated with diabetes. Clinical studies support the vascular…”
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Identification of Nrf2-responsive microRNA networks as putative mediators of myocardial reductive stress by Quiles, Justin M., Pepin, Mark E., Sunny, Sini, Shelar, Sandeep B., Challa, Anil K., Dalley, Brian, Hoidal, John R., Pogwizd, Steven M., Wende, Adam R., Rajasekaran, Namakkal S.

“…Although recent advances in the treatment of acute coronary heart disease have reduced mortality rates, few therapeutic strategies exist to mitigate the…”
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Nrf2 deficiency promotes apoptosis and impairs PAX7/MyoD expression in aging skeletal muscle cells by Narasimhan, Madhusudhanan, Hong, Jennifer, Atieno, Nancy, Muthusamy, Vasanthi R., Davidson, Christopher J., Abu-Rmaileh, Naser, Richardson, Russell S., Gomes, Aldrin V., Hoidal, John R., Rajasekaran, Namakkal S.

“…Skeletal muscle redox homeostasis is transcriptionally regulated by nuclear erythroid-2-p45-related factor-2 (Nrf2). We recently demonstrated that…”
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Autophagy is an adaptive response in desmin-related cardiomyopathy by Tannous, Paul, Zhu, Hongxin, Johnstone, Janet L, Shelton, John M, Rajasekaran, Namakkal S, Benjamin, Ivor J, Nguyen, Lan, Gerard, Robert D, Levine, Beth, Rothermel, Beverly A, Hill, Joseph A

“…A missense mutation in the αB-crystallin (CryAB) gene triggers a severe form of desmin-related cardiomyopathy (DRCM) characterized by accumulation of misfolded…”
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Differential regulation of miRNA and mRNA expression in the myocardium of Nrf2 knockout mice by Quiles, Justin M, Narasimhan, Madhusudhanan, Shanmugam, Gobinath, Milash, Brett, Hoidal, John R, Rajasekaran, Namakkal S

“…Keywords: Nrf2, microRNA, mRNA, Heart, RNA sequencing, Differential expression, Antioxidant, Redox…”
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Exercise mitigates reductive stress-induced cardiac remodeling in mice by Jyothidasan, Arun, Sunny, Sini, Devarajan, Asokan, Sayed, Aniqa, Afortude, John Kofi, Dalley, Brian, Nanda, Vivek, Pogwizd, Steven, Litovsky, Silvio H., Trinity, Joel D., Might, Matthew, Rajasekaran, Namakkal S.

“…The endoplasmic reticulum (ER) regulates protein folding and maintains proteostasis in cells. We observed that the ER transcriptome is impaired during chronic…”
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Reductive stress promotes protein aggregation and impairs neurogenesis by S Narasimhan, Kishore Kumar, Devarajan, Asokan, Karan, Goutam, Sundaram, Sandhya, Wang, Qin, van Groen, Thomas, Monte, Federica del, Rajasekaran, Namakkal S.

“…Redox homeostasis regulates key cellular signaling in both physiology and pathology. While perturbations result in shifting the redox homeostasis towards…”
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Disruption of nuclear factor (erythroid‐derived‐2)‐like 2 antioxidant signaling: a mechanism for impaired activation of stem cells and delayed regeneration of skeletal muscle by Shelar, Sandeep Balu, Narasimhan, Madhusudhanan, Shanmugam, Gobinath, Litovsky, Silvio Hector, Gounder, Sellamuthu S., Karan, Goutam, Arulvasu, Cinnasamy, Kensler, Thomas W., Hoidal, John R., Darley‐Usmar, Victor M., Rajasekaran, Namakkal S.

“…Recently we have reported that age‐dependent decline in antioxidant levels accelerated apoptosis and skeletal muscle degeneration. Here, we demonstrate genetic…”
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Evaluation of the Effect of Diminished Pulsatility as seen in Continuous Flow Ventricular Assist Devices on Arterial Endothelial Cell Phenotype and Function by Patibandla, Phani K, Rajasekeran, Namakkal S, Shelar, Sandeep B, Giridharan, Guruprasad A, Litovsky, Silvio H, Sethu, Palaniappan

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Identification of transcriptome signature for myocardial reductive stress by Quiles, Justin M., Narasimhan, Madhusudhanan, Mosbruger, Timothy, Shanmugam, Gobinath, Crossman, David, Rajasekaran, Namakkal S.

“…The nuclear factor erythroid 2 like 2 (Nfe2l2/Nrf2) is a master regulator of antioxidant gene transcription. We recently identified that constitutive…”
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Case report: Metastatic myxoid liposarcoma arising from the right atrium extends as cardiac tamponade-A rare case of atrial oncology by Thoddi Ramamurthy, Muralidharan, Kumar Balakrishnan, Vinod, Sunny, Sini, Rajkumar, Abinayaa, Sundaram, Sandhya, Krishnamurthy, Preetam, Boopathy Senguttuvan, Nagendra, Murali, Arunan, Santhosham, J D Roy, Periandavan, Kalaiselvi, Rajasekaran, Namakkal S

“…The reported incidence of liposarcomas in ~2,000 cases annually results in about 30% of myxoid liposarcomas. Cardiac myoxid liposarcomas are very rare; their…”
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Chronic Endurance Exercise Impairs Cardiac Structure and Function in Middle-Aged Mice with Impaired Nrf2 Signaling by Shanmugam, Gobinath, Narasimhan, Madhusudhanan, Conley, Robbie L, Sairam, Thiagarajan, Kumar, Ashutosh, Mason, Ronald P, Sankaran, Ramalingam, Hoidal, John R, Rajasekaran, Namakkal S

“…Nuclear factor erythroid 2 related factor 2 (Nrf2) signaling maintains the redox homeostasis and its activation is shown to suppress cardiac maladaptation…”
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