Search Results - "Rajasekaran, Ganesan"

Engineered Cyclotides with Potent Broad in Vitro and in Vivo Antimicrobial Activity by Ganesan, Rajasekaran, Dughbaj, Mansour A., Ramirez, Lisa, Beringer, Steven, Aboye, Teshome L., Shekhtman, Alexander, Beringer, Paul M., Camarero, Julio A.

“…The search for novel antimicrobial agents to combat microbial pathogens is intensifying in response to the rapid development of drug resistance to current…”
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Antimicrobial and anti-inflammatory activities of chemokine CXCL14-derived antimicrobial peptide and its analogs by Rajasekaran, Ganesan, Dinesh Kumar, S., Nam, Jiyoung, Jeon, Dasom, Kim, Yangmee, Lee, Chul Won, Park, Il-Seon, Shin, Song Yub

“…CXCL14 is a CXC chemokine family that exhibits antimicrobial activity and contains an amphipathic cationic α-helical region in the C-terminus, a characteristic…”
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Cationic Amphipathic Triazines with Potent Anti-bacterial, Anti-inflammatory and Anti-atopic Dermatitis Properties by Gunasekaran, Pethaiah, Rajasekaran, Ganesan, Han, Eun Hee, Chung, Young-Ho, Choi, Young-Jin, Yang, Yu Jin, Lee, Ji Eun, Kim, Hak Nam, Lee, Kiram, Kim, Jin-Seok, Lee, Hyun-Jun, Choi, Eun-Ju, Kim, Eun-Kyung, Shin, Song Yub, Bang, Jeong Kyu

“…The emergence of multi-drug resistant bacteria forces the therapeutic world into a position, where the development of new and alternative kind of antibiotics…”
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Fowlicidin-3 Analog with Improved Cell Selectivity Synthesized by Shifting a PXXP Motif from the N-Terminus to a Central Position by Rajasekaran, Ganesan, Shin, Song Yub

“…Fowlicidin-3 (Fow-3), a chicken-derived cathelicidin, is an antimicrobial peptide with considerable antimicrobial activity and mammalian cell toxicity. To…”
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LL-37-derived short antimicrobial peptide KR-12-a5 and its d-amino acid substituted analogs with cell selectivity, anti-biofilm activity, synergistic effect with conventional antibiotics, and anti-inflammatory activity by Kim, Eun Young, Rajasekaran, Ganesan, Shin, Song Yub

“…KR-12-a5 is a 12-meric α-helical antimicrobial peptide (AMP) with dual antimicrobial and anti-inflammatory activities designed from human cathelicidin LL-37…”
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LL-37-derived membrane-active FK-13 analogs possessing cell selectivity, anti-biofilm activity and synergy with chloramphenicol and anti-inflammatory activity by Rajasekaran, Ganesan, Kim, Eun Young, Shin, Song Yub

“…Although the human-derived antimicrobial peptide (AMP) LL-37 has potent antimicrobial and anti-inflammatory activities, its therapeutic application is limited…”
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Resistance is futile: targeting multidrug-resistant bacteria with Cys-rich cyclic polypeptides by Mourenza, Alvaro, Ganesan, Rajasekaran, Camarero, Julio A

“…The search for novel antimicrobial agents to combat microbial pathogens is intensifying in response to rapid drug resistance development to current antibiotic…”
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The design of a cell-selective fowlicidin-1-derived peptide with both antimicrobial and anti-inflammatory activities by Rajasekaran, Ganesan, Kumar, S. Dinesh, Yang, Sungtae, Shin, Song Yub

“…Fowlicidin-1 (Fowl-1), a cathelicidin expressed in chicken intestine, is known to have both antimicrobial and anti-inflammatory properties. However, its…”
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Structural and Functional Assessment of mBjAMP1, an Antimicrobial Peptide from Branchiostoma japonicum, Revealed a Novel α‑Hairpinin-like Scaffold with Membrane Permeable and DNA Binding Activity by Nam, Jiyoung, Yun, Hyosuk, Rajasekaran, Ganesan, Kumar, S. Dinesh, Kim, Jae Il, Min, Hye Jung, Shin, Song Yub, Lee, Chul Won

“…Here we describe the three-dimensional structure and antimicrobial mechanism of mBjAMP1, an antimicrobial peptide (AMP) isolated from Branchiostoma japonicum…”
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Chemical Synthesis of a Potent Antimicrobial Peptide Murepavadin Using a Tandem Native Chemical Ligation/Desulfurization Reaction by Chaudhuri, Dipankar, Ganesan, Rajasekaran, Vogelaar, Alicia, Dughbaj, Mansour A, Beringer, Paul M, Camarero, Julio A

“…Classical approaches for the backbone cyclization of polypeptides require conditions that may compromise the chirality of the C-terminal residue during the…”
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Resistance is futile: targeting multidrug-resistant bacteria with de novo Cys-rich cyclic polypeptides by Mourenza, Alvaro, Ganesan, Rajasekaran, Camarero, Julio A.

“…The search for novel antimicrobial agents to combat microbial pathogens is intensifying in response to rapid drug resistance development to current antibiotic…”
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Enhancement of the anti-inflammatory activity of temporin-1Tl-derived antimicrobial peptides by tryptophan, arginine and lysine substitutions by Rajasekaran, Ganesan, Kamalakannan, Radhakrishnan, Shin, Song Yub

“…Temporin‐1Tl (TL) is a 13‐residue frog antimicrobial peptide (AMP) exhibiting potent antimicrobial and anti‐inflammatory activity. To develop novel AMP with…”
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Cover Feature: Engineered Cyclotides with Potent Broad in Vitro and in Vivo Antimicrobial Activity (Chem. Eur. J. 49/2021) by Ganesan, Rajasekaran, Dughbaj, Mansour A., Ramirez, Lisa, Beringer, Steven, Aboye, Teshome L., Shekhtman, Alexander, Beringer, Paul M., Camarero, Julio A.

“…ESKAPE kit: A novel engineered cyclotide has effective broad‐spectrum antibacterial activity against several ESKAPE bacterial clinical isolates. The most…”
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Fowlicidin‐3 Analog with Improved Cell Selectivity Synthesized by Shifting a PXXP Motif from the N‐Terminus to a Central Position by Rajasekaran, Ganesan, Shin, Song Yub

“…Fowlicidin‐3 (Fow‐3), a chicken‐derived cathelicidin, is an antimicrobial peptide with considerable antimicrobial activity and mammalian cell toxicity. To…”
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DNA Free Energy-Based Promoter Prediction and Comparative Analysis of Arabidopsis and Rice Genomes by Morey, Czuee, Mookherjee, Sushmita, Rajasekaran, Ganesan, Bansal, Manju

“…The cis-regulatory regions on DNA serve as binding sites for proteins such as transcription factors and RNA polymerase. The combinatorial interaction of these…”
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Pyrazole derived ultra-short antimicrobial peptidomimetics with potent anti-biofilm activity by Ahn, Mija, Gunasekaran, Pethaiah, Rajasekaran, Ganesan, Kim, Eun Young, Lee, Soo-Jae, Bang, Geul, Cho, Kun, Hyun, Jae-Kyung, Lee, Hyun-Ju, Jeon, Young Ho, Kim, Nam-Hyung, Ryu, Eun Kyoung, Shin, Song Yub, Bang, Jeong Kyu

“…In this study, we report on the first chemical synthesis of ultra-short pyrazole-arginine based antimicrobial peptidomimetics derived from the newly…”
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Enhancement of the anti-inflammatory activity of temporin-1Tl-derived antimicrobial peptides by tryptophan, arginine and lysine substitutions: TEMPORIN-1Tl ANALOGS WITH IMPROVED ANTI-INFLAMMATORY ACTIVITY by Rajasekaran, Ganesan, Kamalakannan, Radhakrishnan, Shin, Song Yub

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Rattusin structure reveals a novel defensin scaffold formed by intermolecular disulfide exchanges by Min, Hye Jung, Yun, Hyosuk, Ji, Sehyeon, Rajasekaran, Ganesan, Kim, Jae Il, Kim, Jeong-Sun, Shin, Song Yub, Lee, Chul Won

“…Defensin peptides are essential for innate immunity in humans and other living systems, as they provide protection against infectious pathogens and regulate…”
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Improving Cell Selectivity of Fowlicidin‐1 by Swapping Residues between Pro‐7 and Tyr‐20 by Rajasekaran, Ganesan, Kumar, S. Dinesh, Yang, Sungtae, Shin, Song Yub

“…Fowlicidin‐1 (Fowl‐1) is a cathelicidin antimicrobial peptide from chicken that has potent antimicrobial activity and considerable cytotoxicity for human…”
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stereochemical effect of SMAP-29 and SMAP-18 on bacterial selectivity, membrane interaction and anti-inflammatory activity by Jacob, Binu, Rajasekaran, Ganesan, Kim, Eun Young, Park, Il-Seon, Bang, Jeong-Kyu, Shin, Song Yub

“…Sheep myeloid antimicrobial peptide-29 (SMAP-29) is a cathelicidin-related antimicrobial peptide derived from sheep myeloid cells. In order to investigate the…”
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