Search Results - "Rajaratnam, Shantha M"

The Impact of Shift Work on Sleep, Alertness and Performance in Healthcare Workers by Ganesan, Saranea, Magee, Michelle, Stone, Julia E., Mulhall, Megan D., Collins, Allison, Howard, Mark E., Lockley, Steven W., Rajaratnam, Shantha M. W., Sletten, Tracey L.

“…Shift work is associated with impaired alertness and performance due to sleep loss and circadian misalignment. This study examined sleep between shift types…”
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Exposure to Room Light before Bedtime Suppresses Melatonin Onset and Shortens Melatonin Duration in Humans by Gooley, Joshua J, Chamberlain, Kyle, Smith, Kurt A, Khalsa, Sat Bir S, Rajaratnam, Shantha M. W, Van Reen, Eliza, Zeitzer, Jamie M, Czeisler, Charles A, Lockley, Steven W

“…Room light exerts a profound suppressive effect on melatonin levels and shortens the body's internal representation of night duration. Context: Millions of…”
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Cognitive Behavioral Therapy for Chronic Insomnia: A Systematic Review and Meta-analysis by Trauer, James M, Qian, Mary Y, Doyle, Joseph S, Rajaratnam, Shantha M W, Cunnington, David

“…Because psychological approaches are likely to produce sustained benefits without the risk for tolerance or adverse effects associated with pharmacologic…”
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Efficacy of melatonin for sleep disturbance following traumatic brain injury: a randomised controlled trial by Grima, Natalie A, Rajaratnam, Shantha M W, Mansfield, Darren, Sletten, Tracey L, Spitz, Gershon, Ponsford, Jennie L

“…The study aimed to determine the efficacy of melatonin supplementation for sleep disturbances in patients with traumatic brain injury (TBI). This is a…”
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Spectral responses of the human circadian system depend on the irradiance and duration of exposure to light by Gooley, Joshua J, Rajaratnam, Shantha M W, Brainard, George C, Kronauer, Richard E, Czeisler, Charles A, Lockley, Steven W

“…In humans, modulation of circadian rhythms by light is thought to be mediated primarily by melanopsin-containing retinal ganglion cells, not rods or cones…”
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Sleep Disorders, Health, and Safety in Police Officers by Rajaratnam, Shantha M. W, Barger, Laura K, Lockley, Steven W, Shea, Steven A, Wang, Wei, Landrigan, Christopher P, O’Brien, Conor S, Qadri, Salim, Sullivan, Jason P, Cade, Brian E, Epstein, Lawrence J, White, David P, Czeisler, Charles A, Harvard Work Hours, Health and Safety Group, for the

“…CONTEXT Sleep disorders often remain undiagnosed. Untreated sleep disorders among police officers may adversely affect their health and safety and pose a risk…”
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Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial by Sletten, Tracey L, Magee, Michelle, Murray, Jade M, Gordon, Christopher J, Lovato, Nicole, Kennaway, David J, Gwini, Stella M, Bartlett, Delwyn J, Lockley, Steven W, Lack, Leon C, Grunstein, Ronald R, Rajaratnam, Shantha M W

“…Delayed Sleep-Wake Phase Disorder (DSWPD) is characterised by sleep initiation insomnia when attempting sleep at conventional times and difficulty waking at…”
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High sensitivity and interindividual variability in the response of the human circadian system to evening light by Phillips, Andrew J. K., Vidafar, Parisa, Burns, Angus C., McGlashan, Elise M., Anderson, Clare, Rajaratnam, Shantha M. W., Lockley, Steven W., Cain, Sean W.

“…Before the invention of electric lighting, humans were primarily exposed to intense (>300 lux) or dim (<30 lux) environmental light—stimuli at extreme ends of…”
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Mental Health During the COVID-19 Pandemic: Challenges, Populations at Risk, Implications, and Opportunities by Czeisler, Mark É., Howard, Mark E., Rajaratnam, Shantha M. W.

“…The coronavirus disease 2019 (COVID-19) pandemic has had a profound worldwide impact on health. As of mid-December 2020, 77 million confirmed cases of severe…”
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Early public adherence with and support for stay-at-home COVID-19 mitigation strategies despite adverse life impact: a transnational cross-sectional survey study in the United States and Australia by Czeisler, Mark É, Howard, Mark E, Robbins, Rebecca, Barger, Laura K, Facer-Childs, Elise R, Rajaratnam, Shantha M W, Czeisler, Charles A

“…Governments worldwide recommended unprecedented measures to contain the coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory…”
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A Randomized Controlled Trial of Cognitive Behavioral Therapy for Insomnia: An Effective Treatment for Comorbid Insomnia and Depression by Ashworth, Damon K., Sletten, Tracey L., Junge, Moira, Simpson, Katrina, Clarke, David, Cunnington, David, Rajaratnam, Shantha M. W.

“…Insomnia and depression are highly comorbid conditions that show a complex, bidirectional relationship. This study examined whether cognitive-behavioral…”
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On-road driving impairment following sleep deprivation differs according to age by Cai, Anna W. T., Manousakis, Jessica E., Singh, Bikram, Kuo, Jonny, Jeppe, Katherine J., Francis-Pester, Elly, Shiferaw, Brook, Beatty, Caroline J., Rajaratnam, Shantha M. W., Lenné, Michael G., Howard, Mark E., Anderson, Clare

“…Impaired driving performance due to sleep loss is a major contributor to motor-vehicle crashes, fatalities, and serious injuries. As on-road,…”
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Direct and Indirect Mental Health Consequences of the COVID-19 Pandemic Parallel Prior Pandemics by Czeisler, Mark É., Howard, Mark E., Rajaratnam, Shantha M. W.

“…A century ago, Karl Menninger, MD, documented adverse mental health consequences of the 1918 influenza pandemic,1-3 publishing a case series of patients with…”
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Circadian and wake-dependent changes in human plasma polar metabolites during prolonged wakefulness: A preliminary analysis by Grant, Leilah K., Ftouni, Suzanne, Nijagal, Brunda, De Souza, David P., Tull, Dedreia, McConville, Malcolm J., Rajaratnam, Shantha M. W., Lockley, Steven W., Anderson, Clare

“…Establishing circadian and wake-dependent changes in the human metabolome are critical for understanding and treating human diseases due to circadian…”
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The impact of shift work schedules on PVT performance in naturalistic settings: a systematic review by Ferris, Matthew, Bowles, Kelly-Ann, Bray, Mikaela, Bosley, Emma, Rajaratnam, Shantha M. W., Wolkow, Alexander P.

“…Objective The Psychomotor Vigilance Test (PVT) is considered the gold standard for detecting sleep loss and circadian misalignment related changes in…”
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Follow-up Survey of US Adult Reports of Mental Health, Substance Use, and Suicidal Ideation During the COVID-19 Pandemic, September 2020 by Czeisler, Mark É, Lane, Rashon I, Wiley, Joshua F, Czeisler, Charles A, Howard, Mark E, Rajaratnam, Shantha M W

“…This survey study compared patterns of mental health concerns, substance use, and suicidal ideation during June and September 2020 of the COVID-19 pandemic and…”
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Endogenous circadian regulation of female reproductive hormones by Rahman, Shadab A, Grant, Leilah K, Gooley, Joshua J, Rajaratnam, Shantha M W, Czeisler, Charles A, Lockley, Steven W

“…Studies suggest that female reproductive hormones are under circadian regulation, although methodological differences have led to inconsistent findings. To…”
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The pupillary light reflex distinguishes between circadian and non-circadian delayed sleep phase disorder (DSPD) phenotypes in young adults by McGlashan, Elise M, Burns, Angus C, Murray, Jade M, Sletten, Tracey L, Magee, Michelle, Rajaratnam, Shantha M W, Cain, Sean W

“…This study investigated the utility of the pupillary light reflex as a method of differentiating DSPD patients with delayed melatonin timing relative to…”
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Cognitive behavioural therapy for post-stroke fatigue and sleep disturbance: a pilot randomised controlled trial with blind assessment by Nguyen, Sylvia, Wong, Dana, McKay, Adam, Rajaratnam, Shantha M.W., Spitz, Gershon, Williams, Gavin, Mansfield, Darren, Ponsford, Jennie L.

“…The objective of this study was to evaluate the effectiveness of individual cognitive behavioural therapy (CBT) for post-stroke fatigue and sleep disturbance…”
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Melatonin agonist tasimelteon (VEC-162) for transient insomnia after sleep-time shift: two randomised controlled multicentre trials by Rajaratnam, Shantha MW, PhD, Polymeropoulos, Mihael H, MD, Fisher, Dennis M, MD, Roth, Thomas, PhD, Scott, Christin, MS, Birznieks, Gunther, MS, Klerman, Elizabeth B, Dr

“…Summary Background Circadian rhythm sleep disorders are common causes of insomnia for millions of individuals. We did a phase II study to establish efficacy…”
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