Search Results - "Rajaram, V"
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Role of Cardiac Macrophages on Cardiac Inflammation, Fibrosis and Tissue Repair
Published in Cells (Basel, Switzerland) (31-12-2020)“…The immune system plays a pivotal role in the initiation, development and resolution of inflammation following insult or damage to organs. The heart is a vital…”
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Pseudomonas aeruginosa pulmonary infection results in S100A8/A9-dependent cardiac dysfunction
Published in PLoS pathogens (25-08-2023)“…Pseudomonas aeruginosa ( P . a .) infection accounts for nearly 20% of all cases of hospital acquired pneumonia with mortality rates >30%. P . a . infection…”
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An optimized clustering using hybrid meta‐heuristic approach for wireless sensor networks
Published in International journal of communication systems (01-12-2020)“…Summary Power efficiency is one of the major attributes that has to be concentrated in wireless sensor network (WSN). Efficiency in the consumption of power is…”
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Mycobacterium tuberculosis lipomannan blocks TNF biosynthesis by regulating macrophage MAPK-activated protein kinase 2 (MK2) and microRNA miR-125b
Published in Proceedings of the National Academy of Sciences - PNAS (18-10-2011)“…Contact of Mycobacterium tuberculosis (M.tb) with the immune system requires interactions between microbial surface molecules and host pattern recognition…”
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Blood-Borne Lipopolysaccharide Is Rapidly Eliminated by Liver Sinusoidal Endothelial Cells via High-Density Lipoprotein
Published in The Journal of immunology (1950) (15-09-2016)“…During Gram-negative bacterial infections, excessive LPS induces inflammation and sepsis via action on immune cells. However, the bulk of LPS can be cleared…”
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Fine tuning inflammation at the front door: macrophage complement receptor 3-mediates phagocytosis and immune suppression for Francisella tularensis
Published in PLoS pathogens (01-01-2013)“…Complement receptor 3 (CR3, CD11b/CD18) is a major macrophage phagocytic receptor. The biochemical pathways through which CR3 regulates immunologic responses…”
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CD36-Mediated Uptake of Surfactant Lipids by Human Macrophages Promotes Intracellular Growth of Mycobacterium tuberculosis
Published in The Journal of immunology (1950) (15-12-2016)“…Mycobacterium tuberculosis imposes a large global health burden as the airborne agent of tuberculosis. Mycobacterium tuberculosis has been flourishing in human…”
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The Renin-Angiotensin-Aldosterone System Regulates Sarcoidosis Granulomatous Inflammation
Published in American journal of respiratory and critical care medicine (15-08-2024)“…Sarcoidosis is a granulomatous disorder of unclear cause notable for abnormal elevation of blood and tissue ACE1 (angiotensin converting enzyme 1) levels and…”
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RETRACTED ARTICLE: Multi-hop optimized routing algorithm and load balanced fuzzy clustering in wireless sensor networks
Published in Journal of ambient intelligence and humanized computing (01-03-2021)“…Now-a-days, wireless sensor node acts as a basement for a higher level industrial internet of things application. Any kind of real time IoT applications sense…”
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NOD2 controls the nature of the inflammatory response and subsequent fate of Mycobacterium tuberculosis and M. bovis BCG in human macrophages
Published in Cellular microbiology (01-03-2011)“…Mycobacterium tuberculosis (M.tb), which causes tuberculosis, is a host-adapted intracellular pathogen of macrophages. Intracellular pattern recognition…”
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Targeting CBLB as a potential therapeutic approach for disseminated candidiasis
Published in Nature medicine (01-08-2016)“…Jian Zhang and colleagues identify the E3 ubiquitin ligase CBLB as a major inhibitor of host defense against Candida albicans infection and show that targeting…”
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IFITM3 protects the heart during influenza virus infection
Published in Proceedings of the National Academy of Sciences - PNAS (10-09-2019)“…Influenza virus can disseminate from the lungs to the heart in severe infections and can induce cardiac pathology, but this has been difficult to study due to…”
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Mycobacterium tuberculosis decreases human macrophage IFN-γ responsiveness through miR-132 and miR-26a
Published in The Journal of immunology (1950) (01-11-2014)“…IFN-γ-activated macrophages play an essential role in controlling intracellular pathogens; however, macrophages also serve as the cellular home for the…”
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Nontuberculous mycobacterium M. avium infection predisposes aged mice to cardiac abnormalities and inflammation
Published in Aging cell (01-06-2019)“…Biological aging dynamically alters normal immune and cardiac function, favoring the production of pro‐inflammatory cytokines (IL‐1β, IL‐6, and TNF‐α) and…”
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The Battle of LPS Clearance in Host Defense vs. Inflammatory Signaling
Published in Cells (Basel, Switzerland) (21-09-2024)“…Lipopolysaccharide (LPS) in blood circulation causes endotoxemia and is linked to various disease conditions. Current treatments focus on preventing LPS from…”
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Mannose Receptor-Dependent Delay in Phagosome Maturation by Mycobacterium avium Glycopeptidolipids
Published in Infection and Immunity (01-01-2010)“…The ability of pathogenic mycobacteria to block phagosome-lysosome fusion is critical for its pathogenesis. The molecules expressed by mycobacteria that…”
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Molecular composition of the alveolar lining fluid in the aging lung
Published in AGE (01-06-2014)“…As we age, there is an increased risk for the development of pulmonary diseases, including infections, but few studies have considered changes in lung…”
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γ-Tilmanocept, a New Radiopharmaceutical Tracer for Cancer Sentinel Lymph Nodes, Binds to the Mannose Receptor (CD206)
Published in The Journal of immunology (1950) (01-09-2015)“…γ-Tilmanocept ((99m)Tc-labeled-tilmanocept or [(99m)Tc]-tilmanocept) is the first mannose-containing, receptor-directed, radiolabeled tracer for the highly…”
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Scavenger receptor B1, the HDL receptor, is expressed abundantly in liver sinusoidal endothelial cells
Published in Scientific reports (11-02-2016)“…Cholesterol from peripheral tissue, carried by HDL, is metabolized in the liver after uptake by the HDL receptor, SR-B1. Hepatocytes have long been considered…”
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