Search Results - "Rajani, Rikesh M"

Endothelial cell-oligodendrocyte interactions in small vessel disease and aging by Rajani, Rikesh M, Williams, Anna

“…Cerebral small vessel disease (SVD) is a prevalent, neurological disease that significantly increases the risk of stroke and dementia. The main pathological…”
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Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats by Rajani, Rikesh M, Quick, Sophie, Ruigrok, Silvie R, Graham, Delyth, Harris, Sarah E, Verhaaren, Benjamin F J, Fornage, Myriam, Seshadri, Sudha, Atanur, Santosh S, Dominiczak, Anna F, Smith, Colin, Wardlaw, Joanna M, Williams, Anna

“…Dementia is a major social and economic problem for our aging population. One of the most common of dementia in the elderly is cerebral small vessel disease…”
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Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer's disease by Rajani, Rikesh M, Ellingford, Robert, Hellmuth, Mariam, Harris, Samuel S, Taso, Orjona S, Graykowski, David, Lam, Francesca Kar Wey, Arber, Charles, Fertan, Emre, Danial, John S H, Swire, Matthew, Lloyd, Marcus, Giovannucci, Tatiana A, Bourdenx, Mathieu, Klenerman, David, Vassar, Robert, Wray, Selina, Sala Frigerio, Carlo, Busche, Marc Aurel

“…Reduction of amyloid beta (Aβ) has been shown to be effective in treating Alzheimer's disease (AD), but the underlying assumption that neurons are the main…”
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Blood brain barrier leakage is not a consistent feature of white matter lesions in CADASIL by Rajani, Rikesh M, Ratelade, Julien, Domenga-Denier, Valérie, Hase, Yoshiki, Kalimo, Hannu, Kalaria, Raj N, Joutel, Anne

“…Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a genetic paradigm of small vessel disease (SVD) caused…”
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A Vessel for Change: Endothelial Dysfunction in Cerebral Small Vessel Disease by Quick, Sophie, Moss, Jonathan, Rajani, Rikesh M., Williams, Anna

“…The blood vessels of the brain are lined with endothelial cells and it has been long known that these help to regulate blood flow to the brain. However, there…”
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Characterisation of early ultrastructural changes in the cerebral white matter of CADASIL small vessel disease using high‐pressure freezing/freeze‐substitution by Rajani, Rikesh M., Dupré, Nicolas, Domenga‐Denier, Valérie, Van Niel, Guillaume, Heiligenstein, Xavier, Joutel, Anne

“…Aims The objective of this study was to elucidate the early white matter changes in CADASIL small vessel disease. Methods We used high‐pressure freezing and…”
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Deep-learning based segmentation of challenging myelin sheaths by Couedic, Thomas Le, Caillon, Raphael, Rossant, Florence, Joutel, Anne, Urien, Helene, Rajani, Rikesh M.

“…The segmentation of axons and myelin in electron microscopy images allows neurologists to highlight the density of axons and the thickness of the myelin…”
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Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer's disease by Rajani, Rikesh M, Ellingford, Robert, Hellmuth, Mariam, Harris, Samuel S, Taso, Orjona S, Graykowski, David, Lam, Francesca Kar Wey, Arber, Charles, Fertan, Emre, Danial, John S. H, Swire, Matthew, Lloyd, Marcus, Giovannucci, Tatiana A, Bourdenx, Mathieu, Klenerman, David, Vassar, Robert, Wray, Selina, Sala Frigerio, Carlo, Busche, Marc Aurel

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