Search Results - "Rajan, Ravi Kumar"

Soy isoflavones exert beneficial effects on letrozole-induced rat polycystic ovary syndrome (PCOS) model through anti-androgenic mechanism by Rajan, Ravi Kumar, M., Siva Selva Kumar, Balaji, Bhaskar

“…Context: Soy is the main source of phytoestrogens, which has long been used as traditional food. One major subtype of phytoestrogens includes isoflavones and…”
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In-silico and in-vitro analysis of novel substituted benzimidazolyl derivatives for antimycobacterial potentials targeting enoyl acyl carrier protein reductase (InhA) by Kuppuswamy, Umaa, Rajan, Ravi Kumar, Kumar, Arvinth, Ramanathan, Muthiah

“…Background The emergence of mutated drug-resistant strains of Mycobacterium tuberculosis has reinvigorated the development of effective chemotherapy for MDR-TB…”
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Crystal structure, Hirshfeld surface analysis, DFT and molecular docking studies on benzohydrazide derivatives as potential inhibitors of prostate cancer by Arjun, H.A., Rajan, Ravi Kumar, Elancheran, R., Ramanathan, M., Bhattacharjee, Atanu, Kabilan, S.

“…Single crystals of (E)-N'-((1‑chloro-3,4-dihydronaphthalen-2-yl)methylene)-3-nitro benzohydrazide and…”
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Piceatannol selectively inhibited the JNK3 enzyme and augmented apoptosis through inhibition of Bcl‐2/Cyt‐c/caspase‐dependent pathways in the oxygen–glucose deprived SHSY‐5Y cell lines: In silico and in vitro study by Rajan, Ravi Kumar, Ramanathan, M.

“…JNK3, a neuronal kinase activated by stress, plays a role in stress‐induced apoptosis, leading to neuronal cell death following cerebral ischemia. This study…”
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Identification and neuroprotective evaluation of a potential c-Jun N-terminal kinase 3 inhibitor through structure-based virtual screening and in-vitro assay by Rajan, Ravi Kumar, Ramanathan, M.

“…The c-Jun N-terminal kinase 3 (JNK3) signaling cascade is activated during cerebral ischemia leading to neuronal damage. The present study was carried out to…”
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Piceatannol improved cerebral blood flow and attenuated JNK3 and mitochondrial apoptotic pathway in a global ischemic model to produce neuroprotection by Rajan, Ravi Kumar, Kumar, Ram Pravin, Ramanathan, M.

“…Cerebral ischemia is one of the leading causes of death and disability worldwide. The only FDA-approved treatment is recanalization with systemic tissue…”
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Predicting phase-I metabolism of piceatannol: an in silico study by Rajan, Ravi Kumar, Engels, Maida, Ramanathan, Muthiah

“…Piceatannol is a natural compound found in plants and can be derived from resveratrol. While resveratrol has been extensively researched for its effects and…”
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Design, Synthesis, and Biological Evaluation of 2‐(2‐Bromo‐3‐nitrophenyl)‐5‐phenyl‐1,3,4‐oxadiazole Derivatives as Possible Anti‐Breast Cancer Agents by Ananth, Arjun H., Manikandan, Natarajan, Rajan, Ravi Kumar, Elancheran, Ramakrishnan, Lakshmithendral, Kunasekaran, Ramanathan, Muthiah, Bhattacharjee, Atanu, Kabilan, Senthamaraikannan

“…Breast Cancer (BCa) is the most often diagnosed cancer among women who were in the late 1940’s. Breast cancer growth is largely dependent on the expression of…”
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C-Glucosyl Xanthone derivative Mangiferin downregulates the JNK3 mediated caspase activation in Almal induced neurotoxicity in differentiated SHSY-5Y neuroblastoma cells by PK, Nafila, Rajan, Ravi Kumar, Nanchappan, Vanitha, Karuppaiah, Arjunan, Chandrasekaran, Jaikanth, Jayaraman, Saravanan, Gunasekaran, Venkatesh

“…C-Glucosyl Xanthone derivatives were assessed to inhibit the JNK3 mediated Caspase pathway in Almal (Aluminum Maltolate) induced neurotoxicity in SHSY-5Y…”
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