Search Results - "Rajamannan, N."

Atorvastatin inhibits calcification and enhances nitric oxide synthase production in the hypercholesterolaemic aortic valve by Rajamannan, N M, Subramaniam, M, Stock, S R, Stone, N J, Springett, M, Ignatiev, K I, McConnell, J P, Singh, R J, Bonow, R O, Spelsberg, T C

“…Objective: To study in a rabbit model the expression of endothelial nitric oxide synthase (eNOS) in association with the development of calcification of the…”
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CALCIFIC AORTIC STENOSIS: FROM BENCH TO THE BEDSIDE—EMERGING CLINICAL AND CELLULAR CONCEPTS by Rajamannan, Nalini M, Gersh, Bernard, Bonow, Robert O

“…Novaro and colleagues have published a retrospective study showing less progression of aortic stenosis in patients on statin treatment as assessed by a…”
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Autologous peripheral blood CD133+ cell implantation for limb salvage in patients with critical limb ischemia by Burt, R K, Testori, A, Oyama, Y, Rodriguez, H E, Yaung, K, Villa, M, Bucha, J M, Milanetti, F, Sheehan, J, Rajamannan, N, Pearce, W H

“…We report the safety and feasibility of autologous CD133+ cell implantation into the lower extremity muscles of patients with critical limb ischemia, whose…”
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TIEG-null mice display an osteopenic gender-specific phenotype by Hawse, J.R, Iwaniec, U.T, Bensamoun, S.F, Monroe, D.G, Peters, K.D, Ilharreborde, B, Rajamannan, N.M, Oursler, M.J, Turner, R.T, Spelsberg, T.C, Subramaniam, M

“…Abstract TGFβ inducible early gene-1 (TIEG) was originally cloned from human osteoblasts (OB) and has been shown to play an important role in TGFβ/Smad…”
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Human aortic valve calcification is associated with an osteoblast phenotype by RAJAMANNAN, Nalini M, SUBRAMANIAM, Malayannan, SPELSBERG, Thomas, RICKARD, David, STOCK, Stuart R, DONOVAN, Janis, SPRINGETT, Margaret, ORSZULAK, Thomas, FULLERTON, David A, TAJIK, A. J, BONOW, Robert O

“…Calcific aortic stenosis is the third most common cardiovascular disease in the United States. We hypothesized that the mechanism for aortic valve…”
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Cell proliferation in carcinoid valve disease: a mechanism for serotonin effects by Rajamannan, N M, Caplice, N, Anthikad, F, Sebo, T J, Orszulak, T A, Edwards, W D, Tajik, J, Schwartz, R S

“…Elevated serum serotonin is associated with carcinoid heart disease, the hallmark of which is valvular thickening. Yet, the mechanistic role of serotonin in…”
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59 ATORVASTATIN ATTENUATES LRP5/WNT-MEDIATED ATHEROSCLEROSIS AND OSTEOPOROSIS IN A MOUSE MODEL OF EXPERIMENTAL HYPERCHOLESTEROLEMIA by Rajamannan, N. M., Subramaniam, M., Caira, F. C., Stock, S., Hefferan, T., Flores, A., Spelsberg, T. C.

“…Atherosclerosis and osteoprorosis are the leading causes of morbidity and mortality in the aging population in the United States. Evidence indicates that…”
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Experimental hypercholesterolemia induces apoptosis in the aortic valve by Rajamannan, N M, Sangiorgi, G, Springett, M, Arnold, K, Mohacsi, T, Spagnoli, L G, Edwards, W D, Tajik, A J, Schwartz, R S

“…Aortic valve disease is presently the number one indication for valve replacement in the United States, yet its molecular mechanisms remain unknown. As…”
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60 DEGENERATIVE VERSUS RHEUMATIC MITRAL VALVE DISEASE: A COMPARISON OF CELLULAR PROLIFERATION AND OSTEOBLAST MEDIATED EXTRACELLULAR MATRIX PRODUCTION by Pandya, S. B., Subramaniam, M., Stock, S. R., Spelsberg, T. C., McCarthy, P. M., Bonow, R. O., Rajamannan, N. M.

“…IntroductionMitral valve disease due to myxomatous degeneration causing mitral regurgitation (MR) and rheumatic fever causing stenosis (MS) are common forms of…”
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46 ATORVASTATIN ATTENUATES VASCULAR GLOMERULI ATHEROSCLEROSIS IN EXPERIMENTAL HYPERCHOLESTEROLEMIA by Gallagher, P., Le, T. A., Pandya, S., McConnell, J., Singh, R., Caira, F., Gocek, J., Subramaniam, M., Spelsberg, T. C., Rajamannan, N. M.

“…BackgroundRecent studies link early renal insufficiency to increased cardiovascular risk factors. Chronic renal nephrosclerosis is a common cause for end stage…”
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49 ATORVASTATIN INHIBITS LOW-DENSITY RECEPTOR-RELATED PROTEIN 5-MEDIATED ECTOPIC BONE FORMATION IN THE AORTIC VALVES OF HYPERLIPIDEMIC RABBITS by Rajamannan, N. M., Subramaniam, M., Secreto, F., McConnell, J. P., Singh, R., Sebo, T. J., Stock, S. R., Bonow, R. O., Spelsberg, T. C.

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36 NEOANGIOGENESIS VIA VEGF EXPRESSION IS ASSOCIATED WITH AN OSTEOBLAST-BONE FORMATION IN CALCIFIED RHEUMATIC HEART VALVES by Rajamannan, N. M., Nealis, T. B., Stock, S., Thennepan, T., Carmichael, S., Rosengart, T., Fredrickson, J., Edwards, W. D., Bonow, R. O., Spelsberg, T. C.

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Low-density lipoprotein and aortic stenosis by Rajamannan, Nalini M

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The low-density lipoprotein-density-pressure theory identifies asymptomatic aortic stenosis patients benefiting from cholesterol lowering therapy: the seas study by Greve, A., Gohlke-Baerwolf, C., Boman, Kurt, Egstrup, K., Kesianemi, Y. A., Ray, S., Pedersen, T., Best, P., Rajamannan, N., Wachtell, K.

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Estrogen-TGFβ cross-talk in bone and other cell types: Role of TIEG, Runx2, and other transcription factors by Hawse, J. R., Subramaniam, M., Ingle, J. N., Oursler, M. J., Rajamannan, N. M., Spelsberg, T. C.

“…It is well established that E2 and TGFβ have major biological effects in multiple tissues, including bone. The signaling pathways through which these two…”
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Apoptosis is Markedly Increased in the Aortic Valves from Rabbits on Hypercholesterolemic Diets by Rajamannan, N

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Aortic stenosis: prognosis and management: Aortic stenosis by Zilberszac, R., Gabriel, H., Maurer, G., Rosenhek, R., Dulgheru, R., Magne, J., Capoulade, R., Pierard, L., Pibarot, P., Lancellotti, P., Zito, C., Todaro, M., Cusma-Piccione, M., Falanga, G., Di Bella, G., Acri, E., Pardeo, A., Virga, V., Barbaro, C., Carerj, S., Lisi, M., Henein, M., Cameli, M., Ballo, P., Reccia, R., Bennati, E., Chiavarelli, M., Maccherini, M., Mondillo, S., Dahl, J., Videbaek, L., Poulsen, M., Rudbaek, T., Pellikka, P., Rasmussen, L., Moller, J., Touati, A., Messika-Zeitoun, D., Himbert, D., Sordi, M., Chiampan, A., Brochet, E., Iung, B., Vahanian, A., Serfaty, J., Muratori, M., Tamborini, G., Gripari, P., Fusini, L., Barbier, P., Salvi, L., Bartorelli, A., Maffessanti, F., Alamanni, F., Pepi, M., Rajamannan, N., Da Silva, C., Manouras, A., Winter, R., Back, M., Ruck, A., Settergren, M., Sahlen, A., Shahgaldi, K.

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Human Degenerative Valve Disease Is Associated With Up-Regulation of Low-Density Lipoprotein Receptor-Related Protein 5 Receptor-Mediated Bone Formation by Caira, Frank C., Stock, Stuart R., Gleason, Thomas G., McGee, Edwin C., Huang, Jie, Bonow, Robert O., Spelsberg, Thomas C., McCarthy, Patrick M., Rahimtoola, Shahbudin H., Rajamannan, Nalini M.

“…Human Degenerative Valve Disease Is Associated With Up-Regulation of Low-Density Lipoprotein Receptor-Related Protein 5 Receptor-Mediated Bone Formation Frank…”
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Atorvastatin inhibits hypercholesterolemia-induced calcification in the aortic valves via the Lrp5 receptor pathway by RAJAMANNAN, Nalini M, SUBRAMANIAM, Malayannan, CAIRA, Frank, STOCK, Stuart R, SPELSBERG, Thomas C

“…Calcific aortic valve disease is the most common indication for surgical valve replacement in the United States. The cellular mechanisms of valve calcification…”
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ATORVASTATIN ATTENUATES LRP5/WNT-MEDIATED ATHEROSCLEROSIS AND OSTEOPOROSIS IN A MOUSE MODEL OF EXPERIMENTAL HYPERCHOLESTEROLEMIA: 59 by Rajamannan, N. M., Subramaniam, M., Caira, F. C., Stock, S., Hefferan, T., Flores, A., Spelsberg, T. C.

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