Antibacterial Activity of Ethanolic Extract of Cinnamon Bark, Honey, and Their Combination Effects against Acne-Causing Bacteria

Antibacterial Activity of Ethanolic Extract of Cinnamon Bark, Honey, and Their Combination Effects against Acne-Causing Bacteria

and are the major skin bacteria that cause the formation of acne. The present study was conducted to investigate antibacterial activity of ethanolic extract of cinnamon bark, honey, and their combination against acne bacteria. The antibacterial activity of extract of cinnamon bark and honey were inv...

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Bibliographic Details
Published in:Scientia pharmaceutica Vol. 85; no. 2; p. 19
Main Authors: Julianti, Elin, Rajah, Kasturi K, Fidrianny, Irda
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 11-04-2017
MDPI
Subjects:
Acne
Antibiotics
Bacteria
Drugs
Ethanol
Herbal medicine
Laboratories
Methods
Oils & fats
Pharmacy
Quality standards
Skin
Solvents
Studies
Indonesia
antibacterial activity
cinnamon
checkerboards method
additive activity
honey
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Summary:and are the major skin bacteria that cause the formation of acne. The present study was conducted to investigate antibacterial activity of ethanolic extract of cinnamon bark, honey, and their combination against acne bacteria. The antibacterial activity of extract of cinnamon bark and honey were investigated against and using disc diffusion. Minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) were attained using Clinical and Laboratory Standard Institute (CLSI) methods. The interaction between cinnamon bark extract and honey was determined using a checkerboards method. The results showed that the MICs of cinnamon bark extract and honey against were 256 µg/mL and 50% / , respectively, while those against were 1024 µg/mL and 50% / , respectively. The MBC of cinnamon bark extract against and were more than 2048 µg/mL, whereas the MBC for honey against and were 100%. The combination of cinnamon bark extract and honey against and showed additive activity with a fractional inhibitory concentration index (FICI) value of 0.625. Therefore, the combination of cinnamon bark extract and honey has potential activity against acne-causing bacteria.
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content type line 23
ISSN:2218-0532
0036-8709
2218-0532
DOI:10.3390/scipharm85020019