Search Results - "Rajagopal, Sudarshan"

How do chemokines navigate neutrophils to the target site: Dissecting the structural mechanisms and signaling pathways by Rajarathnam, Krishna, Schnoor, Michael, Richardson, Ricardo M., Rajagopal, Sudarshan

“…Chemokines play crucial roles in combating microbial infection and initiating tissue repair by recruiting neutrophils in a timely and coordinated manner. In…”
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Teaching old receptors new tricks: biasing seven-transmembrane receptors by Lefkowitz, Robert J, Rajagopal, Sudarshan, Rajagopal, Keshava

“…Key Points Seven-transmembrane receptors (7TMRs), also known as G protein-couple receptors, are the largest class of transmembrane receptors and a common…”
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The role of chemokines and chemokine receptors in pulmonary arterial hypertension by Mamazhakypov, Argen, Viswanathan, Gayathri, Lawrie, Allan, Schermuly, Ralph Theo, Rajagopal, Sudarshan

“…Pulmonary arterial hypertension (PAH) is characterized by progressive pulmonary artery remodelling leading to increased right ventricular pressure overload,…”
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Multiple ligand-specific conformations of the β2-adrenergic receptor by Kahsai, Alem W, Xiao, Kunhong, Rajagopal, Sudarshan, Ahn, Seungkirl, Shukla, Arun K, Sun, Jinpeng, Oas, Terrence G, Lefkowitz, Robert J

“…A quantitative covalent labeling strategy reveals that multiple ligand-specific conformational states are present in the G protein–coupled β 2 -adrenergic…”
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Monitoring protein conformational changes and dynamics using stable-isotope labeling and mass spectrometry by Kahsai, Alem W, Rajagopal, Sudarshan, Sun, Jinpeng, Xiao, Kunhong

“…CDSiL-MS involves labeling cysteine and lysine side chains in proteins with N-ethylmaleimide and succinic anhydride, respectively. Information about the…”
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Community guidelines for GPCR ligand bias: IUPHAR review 32 by Kolb, Peter, Kenakin, Terry, Alexander, Stephen P. H., Bermudez, Marcel, Bohn, Laura M., Breinholt, Christian S., Bouvier, Michel, Hill, Stephen J., Kostenis, Evi, Martemyanov, Kirill A., Neubig, Rick R., Onaran, H. Ongun, Rajagopal, Sudarshan, Roth, Bryan L., Selent, Jana, Shukla, Arun K., Sommer, Martha E., Gloriam, David E.

“…GPCRs modulate a plethora of physiological processes and mediate the effects of one‐third of FDA‐approved drugs. Depending on which ligand activates a…”
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Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9 by Luttrell, Louis M, Wang, Jialu, Plouffe, Bianca, Smith, Jeffrey S, Yamani, Lama, Kaur, Suneet, Jean-Charles, Pierre-Yves, Gauthier, Christophe, Lee, Mi-Hye, Pani, Biswaranjan, Kim, Jihee, Ahn, Seungkirl, Rajagopal, Sudarshan, Reiter, Eric, Bouvier, Michel, Shenoy, Sudha K, Laporte, Stéphane A, Rockman, Howard A, Lefkowitz, Robert J

“…G protein-coupled receptors (GPCRs) use diverse mechanisms to regulate the mitogen-activated protein kinases ERK1/2. β-Arrestins (βArr1/2) are ubiquitous…”
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β-Arrestin- but Not G Protein-Mediated Signaling by the "Decoy" Receptor CXCR7 by Rajagopal, Sudarshan, Kim, Jihee, Ahn, Seungkirl, Craig, Stewart, Lam, Christopher M., Gerard, Norma P., Gerard, Craig, Lefkowitz, Robert J.

“…Ubiquitously expressed seven-transmembrane receptors (7TMRs) classically signal through heterotrimeric G proteins and are commonly referred to as G…”
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A Practical Guide to Approaching Biased Agonism at G Protein Coupled Receptors by Gundry, Jaimee, Glenn, Rachel, Alagesan, Priya, Rajagopal, Sudarshan

“…Biased agonism, the ability of a receptor to differentially activate downstream signaling pathways depending on binding of a "biased" agonist compared to a…”
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Clinical Features and Outcomes of Patients with Sarcoidosis-associated Pulmonary Hypertension by Parikh, Kishan S., Dahhan, Talal, Nicholl, Leigh, Ruopp, Nicole, Pomann, Gina-Maria, Fortin, Terry, Tapson, Victor F., Rajagopal, Sudarshan

“…The presence of pulmonary hypertension (PH) significantly worsens outcomes in patients with advanced sarcoidosis, but its optimal management is unknown. We…”
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Biased agonists of the chemokine receptor CXCR3 differentially control chemotaxis and inflammation by Smith, Jeffrey S, Nicholson, Lowell T, Suwanpradid, Jutamas, Glenn, Rachel A, Knape, Nicole M, Alagesan, Priya, Gundry, Jaimee N, Wehrman, Thomas S, Atwater, Amber Reck, Gunn, Michael D, MacLeod, Amanda S, Rajagopal, Sudarshan

“…The chemokine receptor CXCR3 plays a central role in inflammation by mediating effector/memory T cell migration in various diseases; however, drugs targeting…”
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Location bias contributes to functionally selective responses of biased CXCR3 agonists by Eiger, Dylan Scott, Boldizsar, Noelia, Honeycutt, Christopher Cole, Gardner, Julia, Kirchner, Stephen, Hicks, Chloe, Choi, Issac, Pham, Uyen, Zheng, Kevin, Warman, Anmol, Smith, Jeffrey S., Zhang, Jennifer Y., Rajagopal, Sudarshan

“…Some G protein-coupled receptor (GPCR) ligands act as “biased agonists” that preferentially activate specific signaling transducers over others. Although GPCRs…”
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Quantitative 129Xe MRI detects early impairment of gas-exchange in a rat model of pulmonary hypertension by Virgincar, Rohan S., Nouls, John C., Wang, Ziyi, Degan, Simone, Qi, Yi, Xiong, Xinyu, Rajagopal, Sudarshan, Driehuys, Bastiaan

“…Hyperpolarized 129 Xe magnetic resonance imaging (MRI) is capable of regional mapping of pulmonary gas-exchange and has found application in a wide range of…”
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Nonclassical Monocytes Sense Hypoxia, Regulate Pulmonary Vascular Remodeling, and Promote Pulmonary Hypertension by Yu, Yen-Rei A, Malakhau, Yuryi, Yu, Chen-Hsin A, Phelan, Stefan-Laural J, Cumming, R Ian, Kan, Matthew J, Mao, Lan, Rajagopal, Sudarshan, Piantadosi, Claude A, Gunn, Michael D

“…An increasing body of evidence suggests that bone marrow-derived myeloid cells play a critical role in the pathophysiology of pulmonary hypertension (PH)…”
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Surgical pulmonary embolectomy and catheter-based therapies for acute pulmonary embolism: A contemporary systematic review by Loyalka, Pranav, Ansari, Muhammad Z., Cheema, Faisal H., Miller, Charles C., Rajagopal, Sudarshan, Rajagopal, Keshava

“…Mortality in acute pulmonary embolism (PE) is believed to be principally due to the subgroup of PEs that are massive. Systemic thrombolysis is the therapeutic…”
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What is biased efficacy? Defining the relationship between intrinsic efficacy and free energy coupling by Onaran, H. Ongun, Rajagopal, Sudarshan, Costa, Tommaso

“…Highlights • GPCR signalling involves interactions with multiple transduction proteins. • Differences in the agonist-induced cooperative effect that stabilizes…”
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Biased Agonism as a Mechanism for Differential Signaling by Chemokine Receptors by Rajagopal, Sudarshan, Bassoni, Daniel L., Campbell, James J., Gerard, Norma P., Gerard, Craig, Wehrman, Tom S.

“…Chemokines display considerable promiscuity with multiple ligands and receptors shared in common, a phenomenon that is thought to underlie their biochemical…”
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C-X-C Motif Chemokine Receptor 3 Splice Variants Differentially Activate Beta-Arrestins to Regulate Downstream Signaling Pathways by Smith, Jeffrey S, Alagesan, Priya, Desai, Nimit K, Pack, Thomas F, Wu, Jiao-Hui, Inoue, Asuka, Freedman, Neil J, Rajagopal, Sudarshan

“…Biased agonism, the ability of different ligands for the same receptor to selectively activate some signaling pathways while blocking others, is now an…”
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The LOV Domain Family:  Photoresponsive Signaling Modules Coupled to Diverse Output Domains by Crosson, Sean, Rajagopal, Sudarshan, Moffat, Keith

“…For single-cell and multicellular systems to survive, they must accurately sense and respond to their cellular and extracellular environment. Light is a nearly…”
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Systematic errors in detecting biased agonism: Analysis of current methods and development of a new model-free approach by Onaran, H. Ongun, Ambrosio, Caterina, Uğur, Özlem, Madaras Koncz, Erzsebet, Grò, Maria Cristina, Vezzi, Vanessa, Rajagopal, Sudarshan, Costa, Tommaso

“…Discovering biased agonists requires a method that can reliably distinguish the bias in signalling due to unbalanced activation of diverse transduction…”
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