Search Results - "Rajadhyaksha, Anjali M."

From Gene to Behavior: L-Type Calcium Channel Mechanisms Underlying Neuropsychiatric Symptoms by Kabir, Zeeba D., Martínez-Rivera, Arlene, Rajadhyaksha, Anjali M.

“…The L-type calcium channels (LTCCs) Ca v 1.2 and Ca v 1.3, encoded by the CACNA1C and CACNA1D genes, respectively, are important regulators of calcium influx…”
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Energy deficit in parvalbumin neurons leads to circuit dysfunction, impaired sensory gating and social disability by Inan, Melis, Zhao, Mingrui, Manuszak, Monica, Karakaya, Cansu, Rajadhyaksha, Anjali, Pickel, Virginia M, Schwartz, Theodore H, Goldstein, Peter A, Manfredi, Giovanni

“…Abstract Parvalbumin-expressing, fast spiking interneurons have high-energy demands, which make them particularly susceptible to energy impairment. Recent…”
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A Machine Learning Approach to Predicting Autism Risk Genes: Validation of Known Genes and Discovery of New Candidates by Lin, Ying, Afshar, Shiva, Rajadhyaksha, Anjali M, Potash, James B, Han, Shizhong

“…Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with a strong genetic basis. The role of mutations in ASD has been well established,…”
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L-type calcium channels and neuropsychiatric diseases: Insights into genetic risk variant-associated genomic regulation and impact on brain development by Baker, Madelyn R., Lee, Andrew S., Rajadhyaksha, Anjali M.

“…Recent human genetic studies have linked a variety of genetic variants in the CACNA1C and CACNA1D genes to neuropsychiatric and neurodevelopmental disorders…”
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Sex differences in the medial prefrontal cortical glutamate system by Knouse, Melissa C, McGrath, Anna G, Deutschmann, Andre U, Rich, Matthew T, Zallar, Lia J, Rajadhyaksha, Anjali M, Briand, Lisa A

“…Dysregulation in the prefrontal cortex underlies a variety of psychiatric illnesses, including substance use disorder, depression, and anxiety. Despite the…”
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Regulation of social interaction in mice by a frontostriatal circuit modulated by established hierarchical relationships by Fetcho, Robert N., Hall, Baila S., Estrin, David J., Walsh, Alexander P., Schuette, Peter J., Kaminsky, Jesse, Singh, Ashna, Roshgodal, Jacob, Bavley, Charlotte C., Nadkarni, Viraj, Antigua, Susan, Huynh, Thu N., Grosenick, Logan, Carthy, Camille, Komer, Lauren, Adhikari, Avishek, Lee, Francis S., Rajadhyaksha, Anjali M., Liston, Conor

“…Social hierarchies exert a powerful influence on behavior, but the neurobiological mechanisms that detect and regulate hierarchical interactions are not well…”
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Markers of Celiac Disease and Gluten Sensitivity in Children with Autism by Lau, Nga M, Green, Peter H R, Taylor, Annette K, Hellberg, Dan, Ajamian, Mary, Tan, Caroline Z, Kosofsky, Barry E, Higgins, Joseph J, Rajadhyaksha, Anjali M, Alaedini, Armin

“…Gastrointestinal symptoms are a common feature in children with autism, drawing attention to a potential association with celiac disease or gluten sensitivity…”
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Rescue of Learning and Memory Deficits in the Human Nonsyndromic Intellectual Disability Cereblon Knock-Out Mouse Model by Targeting the AMP-Activated Protein Kinase-mTORC1 Translational Pathway by Bavley, Charlotte C, Rice, Richard C, Fischer, Delaney K, Fakira, Amanda K, Byrne, Maureen, Kosovsky, Maria, Rizzo, Bryant K, Del Prete, Dolores, Alaedini, Armin, Morón, Jose A, Higgins, Joseph J, D'Adamio, Luciano, Rajadhyaksha, Anjali M

“…A homozygous nonsense mutation in the cereblon ( ) gene results in autosomal recessive, nonsyndromic intellectual disability that is devoid of other phenotypic…”
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Extinction of Contextual Cocaine Memories Requires Cav1.2 within D1R-Expressing Cells and Recruits Hippocampal Cav1.2-Dependent Signaling Mechanisms by Burgdorf, Caitlin E, Schierberl, Kathryn C, Lee, Anni S, Fischer, Delaney K, Van Kempen, Tracey A, Mudragel, Vladimir, Huganir, Richard L, Milner, Teresa A, Glass, Michael J, Rajadhyaksha, Anjali M

“…Exposure to cocaine-associated contextual cues contributes significantly to relapse. Extinction of these contextual associations, which involves a new form of…”
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Contribution of D1R-expressing neurons of the dorsal dentate gyrus and Cav1.2 channels in extinction of cocaine conditioned place preference by Burgdorf, Caitlin E, Bavley Charlotte C, Fischer, Delaney K, Walsh, Alexander P, Martinez-Rivera, Arlene, Hackett, Jonathan E, Zallar, Lia J, Ireton, Kyle E, Hofmann, Franz, Hell, Johannes W, Huganir, Richard L, Rajadhyaksha, Anjali M

“…Cocaine-associated contextual cues can trigger relapse behavior by recruiting the hippocampus. Extinction of cocaine-associated contextual memories can reduce…”
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Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon by Akuffo, Afua A., Alontaga, Aileen Y., Metcalf, Rainer, Beatty, Matthew S., Becker, Andreas, McDaniel, Jessica M., Hesterberg, Rebecca S., Goodheart, William E., Gunawan, Steven, Ayaz, Muhammad, Yang, Yan, Karim, Md Rezaul, Orobello, Morgan E., Daniel, Kenyon, Guida, Wayne, Yoder, Jeffrey A., Rajadhyaksha, Anjali M., Schönbrunn, Ernst, Lawrence, Harshani R., Lawrence, Nicholas J., Epling-Burnette, Pearlie K.

“…Upon binding to thalidomide and other immunomodulatory drugs, the E3 ligase substrate receptor cereblon (CRBN) promotes proteosomal destruction by engaging the…”
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Sensory-Derived Glutamate Regulates Presynaptic Inhibitory Terminals in Mouse Spinal Cord by Mende, Michael, Fletcher, Emily V., Belluardo, Josephine L., Pierce, Joseph P., Bommareddy, Praveen K., Weinrich, Jarret A., Kabir, Zeeba D., Schierberl, Kathryn C., Pagiazitis, John G., Mendelsohn, Alana I., Francesconi, Anna, Edwards, Robert H., Milner, Teresa A., Rajadhyaksha, Anjali M., van Roessel, Peter J., Mentis, George Z., Kaltschmidt, Julia A.

“…Circuit function in the CNS relies on the balanced interplay of excitatory and inhibitory synaptic signaling. How neuronal activity influences synaptic…”
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Forebrain elimination of cacna1c mediates anxiety-like behavior in mice by Lee, A S, Ra, S, Rajadhyaksha, Aditi M, Britt, J K, De Jesus-Cortes, H, Gonzales, K L, Lee, A, Moosmang, S, Hofmann, F, Pieper, A A, Rajadhyaksha, Anjali M

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Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration by Del Prete, Dolores, Rice, Richard C., Rajadhyaksha, Anjali M., D'Adamio, Luciano

“…The amyloid precursor protein (APP), whose mutations cause Alzheimer disease, plays an important in vivo role and facilitates transmitter release. Because the…”
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Mutations in FLVCR1 Cause Posterior Column Ataxia and Retinitis Pigmentosa by Rajadhyaksha, Anjali M., Elemento, Olivier, Puffenberger, Erik G., Schierberl, Kathryn C., Xiang, Jenny Z., Putorti, Maria L., Berciano, José, Poulin, Chantal, Brais, Bernard, Michaelides, Michel, Weleber, Richard G., Higgins, Joseph J.

“…The study of inherited retinal diseases has advanced our knowledge of the cellular and molecular mechanisms involved in sensory neural signaling. Dysfunction…”
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Loss of Cav1.2 channels impairs hippocampal theta burst stimulation-induced long-term potentiation by Sridharan, Preethy S, Lu, Yuan, Rice, Richard C, Pieper, Andrew A, Rajadhyaksha, Anjali M

“…CACNA1 C, which codes for the Ca 1.2 isoform of L-type Ca channels (LTCCs), is a prominent risk gene in neuropsychiatric and neurodegenerative conditions. A…”
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Cav1.2 channels mediate persistent chronic stress-induced behavioral deficits that are associated with prefrontal cortex activation of the p25/Cdk5-glucocorticoid receptor pathway by Bavley, Charlotte C., Fischer, Delaney K., Rizzo, Bryant K., Rajadhyaksha, Anjali M.

“…Chronic stress is known to precipitate and exacerbate neuropsychiatric symptoms, and exposure to stress is particularly pathological in individuals with…”
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Cocaine- and stress-primed reinstatement of drug-associated memories elicit differential behavioral and frontostriatal circuit activity patterns via recruitment of L-type Ca2+ channels by Bavley, Charlotte C., Fetcho, Robert N., Burgdorf, Caitlin E., Walsh, Alexander P., Fischer, Delaney K., Hall, Baila S., Sayles, Nicole M., Contoreggi, Natalina H., Hackett, Jonathan E., Antigua, Susan A., Babij, Rachel, De Marco García, Natalia V., Kash, Thomas L., Milner, Teresa A., Liston, Conor, Rajadhyaksha, Anjali M.

“…Cocaine-associated memories are critical drivers of relapse in cocaine-dependent individuals that can be evoked by exposure to cocaine or stress. Whether these…”
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Correction: D-cycloserine improves synaptic transmission in an animal mode of Rett syndrome by Na, Elisa S, De Jesús-Cortés, Héctor, Martinez-Rivera, Arlene, Kabir, Zeeba D, Wang, Jieqi, Ramesh, Vijayashree, Onder, Yasemin, Rajadhyaksha, Anjali M, Monteggia, Lisa M, Pieper, Andrew A

“…[This corrects the article DOI: 10.1371/journal.pone.0183026.]…”
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Scn2a severe hypomorphic mutation decreases excitatory synaptic input and causes autism-associated behaviors by Wang, Hong-Gang, Bavley, Charlotte C, Li, Anfei, Jones, Rebecca M, Hackett, Jonathan, Bayleyen, Yared, Lee, Francis S, Rajadhyaksha, Anjali M, Pitt, Geoffrey S

“…SCN2A, encoding the neuronal voltage-gated Na+ channel NaV1.2, is one of the most commonly affected loci linked to autism spectrum disorders (ASDs). Most…”
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