Search Results - "Rajadas, Sam"

Dodecanoic acid & palmitic acid disarms rifampicin resistance by putatively targeting mycobacterial efflux pump Rv1218c by Nirmal, Christy, Rajadas, Sam, Balasubramanian, Mahizhaveni, Magdaline, Divya, Chilamakuru, Naresh, Dinesh, Rajkumar, Radhakrishnan, A, Paraman, Ramalingam, Mondal, Rajesh, Azger Dusthackeer, V

“…Background & objectives: Drug-resistant tuberculosis (TB) jeopardizes the treatment process with poor outcomes. Efflux pumps (EPs) belonging to the ABC…”
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Differential Culturability of Mycobacterium tuberculosis in Culture-Negative Sputum of Patients With Pulmonary Tuberculosis and in a Simulated Model of Dormancy by Dusthackeer, Azger, Balasubramanian, Magizhaveni, Shanmugam, Govindarajan, Priya, Shanmuga, Nirmal, Christy Rosaline, Sam Ebenezer, Rajadas, Balasubramanian, Angayarkanni, Mondal, Rajesh Kumar, Thiruvenkadam, Kannan, Hemanth Kumar, A. K., Ramachandran, Geetha, Subbian, Selvakumar

“…Tuberculosis (TB) remains a leading killer among infectious diseases of humans worldwide. Delayed diagnosis is a crucial problem in global TB control programs…”
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In-vivo studies on Transitmycin, a potent Mycobacterium tuberculosis inhibitor by Mondal, Rajesh, Dusthackeer V N, Azger, Kannan, Palaniyandi, Singh, Amit Kumar, Thiruvengadam, Kannan, Manikkam, Radhakrishnan, A S, Shainaba, Balasubramanian, Mahizhaveni, Elango, Padmasini, Ebenezer Rajadas, Sam, Bharadwaj, Dinesh, Arumugam, Gandarvakottai Senthilkumar, Ganesan, Suresh, Kumar A K, Hemanth, Singh, Manjula, Patil, Shripad, U C A, Jaleel, Doble, Mukesh, R, Balagurunathan, Tripathy, Srikanth Prasad, Kumar, Vanaja

“…This study involves the in-vitro and in-vivo anti-TB potency and in-vivo safety of Transitmycin (TR) (PubChem CID:90659753)- identified to be a novel secondary…”
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Discovery of a highly potent novel rifampicin analog by preparing a hybrid of the precursors of the antibiotic drugs rifampicin and clofazimine by Saravanan, Pasupathy, Dusthackeer, V. N. Azger, Rajmani, R. S., Mahizhaveni, B., Nirmal, Christy R., Rajadas, Sam Ebenezer, Bhardwaj, Neerupma, Ponnuraja, C., Bhaskar, Adhin, Hemanthkumar, A. K., Ramachandran, Geetha, Tripathy, Srikanth P.

“…Tuberculosis (TB) is an infectious disease caused by the bacillus Mycobacterium tuberculosis (Mtb). The present work reports the design and synthesis of a…”
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Fabrication of bioactive rifampicin loaded κ-Car-MA-INH/Nano hydroxyapatite composite for tuberculosis osteomyelitis infected tissue regeneration by Amarnath Praphakar, Rajendran, Sumathra, Murugan, Sam Ebenezer, Rajadas, Vignesh, Sounderrajan, Shakila, Harshavardhan, Rajan, Mariappan

“…[Display omitted] Biocompatible polymers and ceramic materials have been identified as vital components to fabricate drug delivery and tissue engineering…”
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Versatile pH-Responsive Chitosan-g-Polycaprolactone/Maleic Anhydride–Isoniazid Polymeric Micelle To Improve the Bioavailability of Tuberculosis Multidrugs by Amarnath Praphakar, Rajendran, Sam Ebenezer, Rajadas, Vignesh, Sounderrajan, Shakila, Harshavardhan, Rajan, Mariappan

“…The potential of polymeric micelles constructed by coalescing natural and synthetic polymers for tuberculosis (TB) treatment was evaluated in this work. We…”
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Functionalized chitosan-G-poly caprolactone vaccine delivery system fabricated to display antigen–antibody immune complexes of Mycobacterium tuberculosis elicits immune response in Ex-vivo model by Rajadas, Sam Ebenezer, Sounderrajan, Vignesh, Prabhakaran, Rajendran Amarnath, Agrawal, Ragini, Jeyadoss, Lavanya, Rajan, Mariappan, Parthasarathy, Krupakar, Harshavardhan, Shakila

“…Background Vaccine development against tuberculosis remains a global health imperative, necessitating robust immunogenicity and safety profiles…”
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Wild-Type MIC Distribution for Re-evaluating the Critical Concentration of Anti-TB Drugs and Pharmacodynamics Among Tuberculosis Patients From South India by Dusthackeer, Azger, Saadhali, Shainaba A., Thangam, Manonanthini, Hassan, Sameer, Balasubramanian, Mahizhaveni, Balasubramanian, Angayarkani, Ramachandran, Geetha, Kumar, A. K. Hemanth, Thiruvenkadam, Kannan, Shanmugam, Govindarajan, Nirmal, Christy Rosaline, Rajadas, Sam Ebenezer, Mohanvel, Sucharitha Kannappan, Mondal, Rajesh

“…The World Health Organization (WHO) has developed specific guidelines for critical concentrations (CCs) of antibiotics used for tuberculosis (TB) treatment,…”
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Myoinositol and methyl stearate increases rifampicin susceptibility among drug‐resistant Mycobacterium tuberculosis expressing Rv1819c by Nirmal, Christy Rosaline, Rajadas, Sam Ebenezer, Balasubramanian, Mahizhaveni, Mohanvel, Sucharitha Kannappan, Aathi, Muthu Sankar, Munishankar, Saravanan, Chilamakuru, Naresh Babu, Thiruvenkadam, Kannan, Pandiya Raj, Ajith Kumar, Paraman, Ramalingam, Dusthackeer, Azger

“…The alarming increase in multidrug resistance, which includes Bedaquiline and Delamanid, stumbles success in Tuberculosis treatment outcome. Mycobacterium…”
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Anti-tuberculosis activity of bio-active compounds from Lantana camara L., Euphorbia hirta L., Mukia maderaspatana (L.) M. Roem, and Abutilon indicum (L.) by Nirmal, Christy Rosaline, Ebenezer, Rajadas Sam, Kannan, Priya, Balasubramanian, Mahizhaveni, Thirunavukkarasu, Indira, Mondal, Rajesh, Dusthackeer, Azger

“…Tuberculosis (TB) is a major cause of morbidity and mortality and deserves global attention to identify new effective drugs. The present in-vitro study is an…”
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Protective effect of antigen excess immune complex in guinea pigs infected with Mycobacterium tuberculosis by Ebenezer, Rajadas, Gupta, Umesh, Gupta, Pushpa, Shakila, Harshavardhan

“…Background & objectives: Immune complexes (ICs) play a crucial role which can either be beneficial or pathological to the host. Involvement of circulating…”
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