Search Results - "Rajabhathor, Arvind"
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Novel correlates of protection against pandemic H1N1 influenza A virus infection
Published in Nature medicine (01-06-2019)“…Influenza viruses remain a severe threat to human health, causing up to 650,000 deaths annually 1 , 2 . Seasonal influenza virus vaccines can prevent…”
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Vaccination with a Recombinant H7 Hemagglutinin-Based Influenza Virus Vaccine Induces Broadly Reactive Antibodies in Humans
Published in mSphere (01-11-2017)“…Human influenza virus infections with avian subtype H7N9 viruses are a major public health concern and have encouraged the development of effective H7…”
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Pandemic influenza virus vaccines boost hemagglutinin stalk-specific antibody responses in primed adult and pediatric cohorts
Published in npj vaccines (06-12-2019)“…Licensed influenza virus vaccines target the head domain of the hemagglutinin (HA) glycoprotein which undergoes constant antigenic drift. The highly conserved…”
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Pre-existing Antineuraminidase Antibodies Are Associated With Shortened Duration of Influenza A(H1N1)pdm Virus Shedding and Illness in Naturally Infected Adults
Published in Clinical infectious diseases (23-05-2020)“…Abstract Background Influenza causes a substantial burden worldwide, and current seasonal influenza vaccine has suboptimal effectiveness. To develop better,…”
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Activity of human serum antibodies in an influenza virus hemagglutinin stalk-based ADCC reporter assay correlates with activity in a CD107a degranulation assay
Published in Vaccine (18-02-2020)“…The stalk of the influenza virus hemagglutinin (HA) is an attractive target for antibody-based universal influenza virus vaccine development. While antibodies…”
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Adjuvanted H5N1 influenza vaccine enhances both cross-reactive memory B cell and strain-specific naive B cell responses in humans
Published in Proceedings of the National Academy of Sciences - PNAS (28-07-2020)“…There is a need for improved influenza vaccines. In this study we compared the antibody responses in humans after vaccination with an AS03-adjuvanted versus…”
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Activity of human serum antibodies in a hemagglutinin stalk-based ADCC reporter assay correlates with activity in a CD107a degranulation assay
Published in Vaccine (17-01-2020)“…The stalk of the influenza virus hemagglutinin (HA) is an attractive target for antibody-based universal influenza virus vaccine development. While antibodies…”
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Antibody responses to influenza A(H1N1)pdm infection
Published in Vaccine (02-06-2020)“…•Not all influenza-infected people generate hemagglutination inhibition antibodies.•A subset of individuals respond exclusively to alternate viral targets of…”
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Chimeric Hemagglutinin-Based Influenza Virus Vaccines Induce Protective Stalk-Specific Humoral Immunity and Cellular Responses in Mice
Published in ImmunoHorizons (01-04-2019)“…The high variation of the influenza virus hemagglutinin (HA), particularly of its immunodominant head epitopes, makes it necessary to reformulate seasonal…”
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