Search Results - "Raja, K. Muruga Poopathi"

Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein by Ben Halima, Saoussen, Mishra, Sabyashachi, Raja, K. Muruga Poopathi, Willem, Michael, Baici, Antonio, Simons, Kai, Brüstle, Oliver, Koch, Philipp, Haass, Christian, Caflisch, Amedeo, Rajendran, Lawrence

“…Development of disease-modifying therapeutics is urgently needed for treating Alzheimer disease (AD). AD is characterized by toxic β-amyloid (Aβ) peptides…”
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Polypeptide Helices in Hybrid Peptide Sequences by Ananda, Kuppanna, Vasudev, Prema G, Sengupta, Anindita, Poopathi Raja, K. Muruga, Shamala, Narayanaswamy, Balaram, Padmanabhan

“…A new class of polypeptide helices in hybrid sequences containing α-, β-, and γ-residues is described. The molecular conformations in crystals determined for…”
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Engineering polypeptide folding through trans double bonds: transformation of miniature β-meanders to hybrid helices by Ganesh Kumar, Mothukuri, Benke, Sushil N, Poopathi Raja, K Muruga, Gopi, Hosahudya N

“…Utilization of conjugated double bonds to engineer the novel folded miniature β-meander type structures, single step transformation of miniature β-meanders…”
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Non-classical Helices with cis Carbon-Carbon Double Bonds in the Backbone: Structural Features of α,γ-Hybrid Peptide Foldamers by Ganesh Kumar, Mothukuri, Thombare, Varsha J., Katariya, Mona M., Veeresh, Kuruva, Raja, K. Muruga Poopathi, Gopi, Hosahudya N.

“…The impact of geometrically constrained cis α,β‐unsaturated γ‐amino acids on the folding of α,γ‐hybrid peptides was investigated. Structure analysis in single…”
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Modulating the Structural Properties of α,γ‐Hybrid Peptides by α‐Amino Acid Residues: Uniform 12‐Helix Versus “Mixed” 12/10‐Helix by Misra, Rajkumar, Raja, K. Muruga Poopathi, Hofmann, Hans‐Jörg, Gopi, Hosahudya N

“…The most important natural α‐ and 310‐helices are stabilized by unidirectional intramolecular hydrogen bonds along the helical cylinder. In contrast, we report…”
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Structural Dimorphism of Achiral α,γ‐Hybrid Peptide Foldamers: Coexistence of 12‐ and 15/17‐Helices by Misra, Rajkumar, Saseendran, Abhijith, George, Gijo, Veeresh, Kuruva, Raja, K. Muruga Poopathi, Raghothama, Srinivasarao, Hofmann, Hans‐Jörg, Gopi, Hosahudya N.

“…Here, novel 12‐helices in α,γ‐hybrid peptides composed of achiral α‐aminoisobutyric acid (Aib) and 4‐aminoisocaproic acid (Aic, doubly homologated Aib)…”
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Design of Stable β‑Hairpin Mimetics through Backbone Disulfide Bonds by Ganesh Kumar, Mothukuri, Mali, Sachitanand M, Raja, K. Muruga Poopathi, Gopi, Hosahudya N

“…The synthesis and utilization of novel thiostatines (β-SH-substituted γ-amino acids) in the design of backbone-disulfide-stabilized β-hairpin mimetics,…”
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Synthesis and Structural Investigations of Functionalizable Hybrid β-Hairpin by Bandyopadhyay, Anupam, Mali, Sachitanand M, Lunawat, Pooja, Raja, K. Muruga Poopathi, Gopi, Hosahudya N

“…The solution and solid state conformations of a designed β-hairpin containing functionalizable α,β-unsaturated γ-amino acids at the antiparallel β-strands and…”
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Structural studies of model peptides containing beta-, gamma- and delta-amino acids by Sengupta, Anindita, Aravinda, Subrayashastry, Shamala, Narayanaswamy, Raja, K Muruga Poopathi, Balaram, Padmanabhan

“…The crystal structures of five model peptides Piv-Pro-Gly-NHMe (1), Piv-Pro-betaGly-NHMe (2), Piv-Pro-betaGly-OMe (3), Piv-Pro-deltaAva-OMe (4) and…”
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Stereochemistry of gabapentin and several derivatives: Solid state conformations and solution equilibria by Ananda, K., Aravinda, S., Vasudev, Prema G., Raja, K. Muruga Poopathi, Sivaramakrishnan, H., Nagarajan, K., Shamala, N., Balaram, P.

“…Gabapentin (1-(aminomethyl)cycloheaxaneacetic acid; Gpn) is a widely used anti-epileptic drug. The target site of action of Gpn remains controversial. Gpn can…”
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Modulating the Structural Properties of [alpha],[gamma]-Hybrid Peptides by [alpha]-Amino Acid Residues: Uniform 12-Helix Versus "Mixed" 12/10-Helix by Misra, Rajkumar, Raja, K Muruga Poopathi, Hofmann, Hans-Jörg, Gopi, Hosahudya N

“…The most important natural [alpha]- and 310-helices are stabilized by unidirectional intramolecular hydrogen bonds along the helical cylinder. In contrast, we…”
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Structural Dimorphism of Achiral [alpha],[gamma]-Hybrid Peptide Foldamers: Coexistence of 12- and 15/17-Helices by Misra, Rajkumar, Saseendran, Abhijith, George, Gijo, Veeresh, Kuruva, Raja, K Muruga Poopathi, Raghothama, Srinivasarao, Hofmann, Hans-Jörg, Gopi, Hosahudya N

“…Here, novel 12-helices in [alpha],[gamma]-hybrid peptides composed of achiral [alpha]-aminoisobutyric acid (Aib) and 4-aminoisocaproic acid (Aic, doubly…”
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Non-classical Helices with cis Carbon-Carbon Double Bonds in the Backbone: Structural Features of [alpha],[gamma]-Hybrid Peptide Foldamers by GaneshKumar, Mothukuri, Thombare, Varsha J, Katariya, Mona M, Veeresh, Kuruva, Raja, K Muruga Poopathi, Gopi, Hosahudya N

“…The impact of geometrically constrained cis [alpha],[beta]-unsaturated [gamma]-amino acids on the folding of [alpha],[gamma]-hybrid peptides was investigated…”
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Non-classical Helices with cis Carbon-Carbon Double Bonds in the Backbone: Structural Features of [alpha],[gamma]-Hybrid Peptide Foldamers by GaneshKumar, Mothukuri, Thombare, Varsha J, Katariya, Mona M, Veeresh, Kuruva, Raja, K Muruga Poopathi, Gopi, Hosahudya N

“…The impact of geometrically constrained cis [alpha],[beta]-unsaturated [gamma]-amino acids on the folding of [alpha],[gamma]-hybrid peptides was investigated…”
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C−H⋅⋅⋅O Hydrogen Bond Mediated Chain Reversal in a Peptide Containing a γ-Amino Acid Residue, Determined Directly from Powder X-ray Diffraction Data by Cheung, Eugene Y., McCabe, Emma E., Harris, Kenneth D. M., Johnston, Roy L., Tedesco, Emilio, Raja, K. Muruga Poopathi, Balaram, Padmanabhan

“…Similar to the classical β turn: An intramolecular cyclic 10‐atom motif is defined in the molecular conformation of Piv‐lPro‐γ‐Abu‐NHMe (see powder X‐ray…”
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Non-classical Helices with cis Carbon-Carbon Double Bonds in the Backbone: Structural Features of α,γ-Hybrid Peptide Foldamers by Ganesh Kumar, Mothukuri, Thombare, Varsha J., Katariya, Mona M., Veeresh, Kuruva, Raja, K. Muruga Poopathi, Gopi, Hosahudya N.

“…The impact of geometrically constrained cis α,β‐unsaturated γ‐amino acids on the folding of α,γ‐hybrid peptides was investigated. Structure analysis in single…”
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C-HtriplebondO hydrogen bond mediated chain reversal in a peptide containing a gamma-amino acid residue, determined directly from powder X-ray diffraction data by Cheung, Eugene Y, McCabe, Emma E, Harris, Kenneth D M, Johnston, Roy L, Tedesco, Emilio, Raja, K Muruga Poopathi, Balaram, Padmanabhan

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C−H⋅⋅⋅O Hydrogen Bond Mediated Chain Reversal in a Peptide Containing a γ-Amino Acid Residue, Determined Directly from Powder X-ray Diffraction Data by Cheung, Eugene Y., McCabe, Emma E., Harris, Kenneth D. M., Johnston, Roy L., Tedesco, Emilio, Raja, K. Muruga Poopathi, Balaram, Padmanabhan

“…Der klassischen β‐Schleife ähnlich ist ein cyclisches, aus zehn Atomen bestehendes Strukturmotiv, das durch eine intramolekulare C−H⋅⋅⋅O‐Wechselwirkung bei…”
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C−H⋅⋅⋅O Hydrogen Bond Mediated Chain Reversal in a Peptide Containing aγ-Amino Acid Residue, Determined Directly from Powder X-ray Diffraction Data by Cheung, Eugene Y., McCabe, Emma E., Harris, Kenneth D. M., Johnston, Roy L., Tedesco, Emilio, Raja, K. Muruga Poopathi, Balaram, Padmanabhan

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