Search Results - "Raja, Huzefa A"

Fungal Identification Using Molecular Tools: A Primer for the Natural Products Research Community by Raja, Huzefa A, Miller, Andrew N, Pearce, Cedric J, Oberlies, Nicholas H

“…Fungi are morphologically, ecologically, metabolically, and phylogenetically diverse. They are known to produce numerous bioactive molecules, which makes them…”
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DNA barcoding for identification of consumer-relevant mushrooms: A partial solution for product certification? by Raja, Huzefa A., Baker, Timothy R., Little, Jason G., Oberlies, Nicholas H.

“…•Thirty-three commercially used fungal samples were analyzed via ITS barcoding.•Samples included: powdered mycelium, culinary mushrooms, dietary supplement…”
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Biochemometrics for Natural Products Research: Comparison of Data Analysis Approaches and Application to Identification of Bioactive Compounds by Kellogg, Joshua J, Todd, Daniel A, Egan, Joseph M, Raja, Huzefa A, Oberlies, Nicholas H, Kvalheim, Olav M, Cech, Nadja B

“…A central challenge of natural products research is assigning bioactive compounds from complex mixtures. The gold standard approach to address this challenge,…”
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Variation Among Biosynthetic Gene Clusters, Secondary Metabolite Profiles, and Cards of Virulence Across Aspergillus Species by Steenwyk, Jacob L, Mead, Matthew E, Knowles, Sonja L, Raja, Huzefa A, Roberts, Christopher D, Bader, Oliver, Houbraken, Jos, Goldman, Gustavo H, Oberlies, Nicholas H, Rokas, Antonis

“…Abstract Aspergillus fumigatus is a major fungal pathogen of humans but its two closest relatives, Aspergillus fischeri and Aspergillus oerlinghausenensis, are…”
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Correlative metabologenomics of 110 fungi reveals metabolite–gene cluster pairs by Caesar, Lindsay K., Butun, Fatma A., Robey, Matthew T., Ayon, Navid J., Gupta, Raveena, Dainko, David, Bok, Jin Woo, Nickles, Grant, Stankey, Robert J., Johnson, Don, Mead, David, Cank, Kristof B., Earp, Cody E., Raja, Huzefa A., Oberlies, Nicholas H., Keller, Nancy P., Kelleher, Neil L.

“…Natural products research increasingly applies -omics technologies to guide molecular discovery. While the combined analysis of genomic and metabolomic…”
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Apicidin Attenuates MRSA Virulence through Quorum-Sensing Inhibition and Enhanced Host Defense by Parlet, Corey P., Kavanaugh, Jeffrey S., Crosby, Heidi A., Raja, Huzefa A., El-Elimat, Tamam, Todd, Daniel A., Pearce, Cedric J., Cech, Nadja B., Oberlies, Nicholas H., Horswill, Alexander R.

“…Recurrent epidemics of drug-resistant Staphylococcus aureus illustrate the rapid lapse of antibiotic efficacy following clinical implementation. Over the last…”
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Genome Mining and Molecular Networking-Based Metabolomics of the Marine Facultative Aspergillus sp. MEXU 27854 by Martínez-Cárdenas, Anahí, Cruz-Zamora, Yuridia, Fajardo-Hernández, Carlos A., Villanueva-Silva, Rodrigo, Cruz-García, Felipe, Raja, Huzefa A., Figueroa, Mario

“…The marine-facultative Aspergillus sp. MEXU 27854, isolated from the Caleta Bay in Acapulco, Guerrero, Mexico, has provided an interesting diversity of…”
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Isochromenones, isobenzofuranone, and tetrahydronaphthalenes produced by Paraphoma radicina, a fungus isolated from a freshwater habitat by El-Elimat, Tamam, Raja, Huzefa A., Figueroa, Mario, Falkinham, Joseph O., Oberlies, Nicholas H.

“…Nine compounds were identified from the fungus Paraphoma radicina. The absolute configurations of clearanols F and G were determined by means of TDDFT…”
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Prenylated Diresorcinols Inhibit Bacterial Quorum Sensing by Paguigan, Noemi D, Rivera-Chávez, José, Stempin, Justin J, Augustinović, Mario, Noras, Aleksandra I, Raja, Huzefa A, Todd, Daniel A, Triplett, Kathleen D, Day, Cynthia, Figueroa, Mario, Hall, Pamela R, Cech, Nadja B, Oberlies, Nicholas H

“…Current treatment options for bacterial infections are dependent on antibiotics that inhibit microbial growth and viability. These approaches result in the…”
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Evaluation of culture media for the production of secondary metabolites in a natural products screening program by VanderMolen, Karen M, Raja, Huzefa A, El-Elimat, Tamam, Oberlies, Nicholas H

“…Variation in the growing environment can have significant impacts on the quantity and diversity of fungal secondary metabolites. In the industrial setting,…”
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Biosynthetically Distinct Cytotoxic Polyketides from Setophoma terrestris by El-Elimat, Tamam, Figueroa, Mario, Raja, Huzefa A., Graf, Tyler N., Swanson, Steven M., Falkinham III, Joseph O., Wani, Mansukh C., Pearce, Cedric J., Oberlies, Nicholas H.

“…Sixteen polyketides belonging to diverse structural classes, including monomeric/dimeric tetrahydroxanthones and resorcylic acid lactones, were isolated from…”
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Biosynthesis of Fluorinated Peptaibols Using a Site-Directed Building Block Incorporation Approach by Rivera-Chávez, José, Raja, Huzefa A, Graf, Tyler N, Burdette, Joanna E, Pearce, Cedric J, Oberlies, Nicholas H

“…Synthetic biological approaches, such as site-directed biosynthesis, have contributed to the expansion of the chemical space of natural products, making…”
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Opportunities and Limitations for Assigning Relative Configurations of Antibacterial Bislactones using GIAO NMR Shift Calculations by Knowles, Sonja L, Roberts, Christopher D, Augustinović, Mario, Flores-Bocanegra, Laura, Raja, Huzefa A, Heath-Borrero, Kimberly N, Burdette, Joanna E, Falkinham III, Joseph O, Pearce, Cedric J, Oberlies, Nicholas H

“…Four new bislactones, dihydroacremonol (1), clonostachyone (2), acremodiol B (3), and acremodiol C (4), along with one known compound, hymeglusin (5), were…”
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Enhanced dereplication of fungal cultures via use of mass defect filtering by Paguigan, Noemi D, El-Elimat, Tamam, Kao, Diana, Raja, Huzefa A, Pearce, Cedric J, Oberlies, Nicholas H

“…Effective and rapid dereplication is a hallmark of present-day drug discovery from natural sources. This project strove to both decrease the time and expand…”
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Mapping the Fungal Battlefield: Using in situ Chemistry and Deletion Mutants to Monitor Interspecific Chemical Interactions Between Fungi by Knowles, Sonja L, Raja, Huzefa A, Wright, Allison J, Lee, Ann Marie L, Caesar, Lindsay K, Cech, Nadja B, Mead, Matthew E, Steenwyk, Jacob L, Ries, Laure N A, Goldman, Gustavo H, Rokas, Antonis, Oberlies, Nicholas H

“…Fungi grow in competitive environments, and to cope, they have evolved strategies, such as the ability to produce a wide range of secondary metabolites. This…”
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Chemoselective fluorination and chemoinformatic analysis of griseofulvin: Natural vs fluorinated fungal metabolites by Paguigan, Noemi D., Al-Huniti, Mohammed H., Raja, Huzefa A., Czarnecki, Austin, Burdette, Joanna E., González-Medina, Mariana, Medina-Franco, José L., Polyak, Stephen J., Pearce, Cedric J., Croatt, Mitchell P., Oberlies, Nicholas H.

“…[Display omitted] Griseofulvin is a fungal metabolite and antifungal drug used for the treatment of dermatophytosis in both humans and animals. Recently,…”
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Phylogenomics reveals extensive misidentification of fungal strains from the genus Aspergillus by Steenwyk, Jacob L, Balamurugan, Charu, Raja, Huzefa A, Gonçalves, Carla, Li, Ningxiao, Martin, Frank, Berman, Judith, Oberlies, Nicholas H, Gibbons, John G, Goldman, Gustavo H, Geiser, David M, Houbraken, Jos, Hibbett, David S, Rokas, Antonis

“…Modern taxonomic classification is often based on phylogenetic analyses of a few molecular markers, although single-gene studies are still common. Here, we…”
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Genomic and Phenotypic Analysis of COVID-19-Associated Pulmonary Aspergillosis Isolates of Aspergillus fumigatus by Steenwyk, Jacob L, Mead, Matthew E, de Castro, Patrícia Alves, Valero, Clara, Damasio, André, Dos Santos, Renato A C, Labella, Abigail L, Li, Yuanning, Knowles, Sonja L, Raja, Huzefa A, Oberlies, Nicholas H, Zhou, Xiaofan, Cornely, Oliver A, Fuchs, Frieder, Koehler, Philipp, Goldman, Gustavo H, Rokas, Antonis

“…The ongoing global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for coronavirus disease 2019 (COVID-19),…”
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Genomic and Phenotypic Trait Variation of the Opportunistic Human Pathogen Aspergillus flavus and Its Close Relatives by Hatmaker, E Anne, Rangel-Grimaldo, Manuel, Raja, Huzefa A, Pourhadi, Hadi, Knowles, Sonja L, Fuller, Kevin, Adams, Emily M, Lightfoot, Jorge D, Bastos, Rafael W, Goldman, Gustavo H, Oberlies, Nicholas H, Rokas, Antonis

“…Fungal diseases affect millions of humans annually, yet fungal pathogens remain understudied. The mold Aspergillus flavus can cause both aspergillosis and…”
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Additional α-glucosidase inhibitors from Malbranchea flavorosea (Leotiomycetes, Ascomycota) by Rebollar-Ramos, Daniela, Macías-Ruvalcaba, Martha L., Figueroa, Mario, Raja, Huzefa A., González-Andrade, Martín, Mata, Rachel

“…From the rice-based culture of Malbranchea flavorosea , three new compounds namely flavoroseoside B (5-desoxy-5-chloro-flavoroseoside) ( 2 ), 4-hydroxy-2- O…”
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