Search Results - "Rajão, Matheus Andrade"
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Functional characterization of 8-oxoguanine DNA glycosylase of Trypanosoma cruzi
Published in PloS one (02-08-2012)“…The oxidative lesion 8-oxoguanine (8-oxoG) is removed during base excision repair by the 8-oxoguanine DNA glycosylase 1 (Ogg1). This lesion can erroneously…”
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Overview of DNA Repair in Trypanosoma cruzi, Trypanosoma brucei and Leishmania major
Published in Journal of Nucleic Acids (01-01-2010)“…A wide variety of DNA lesions arise due to environmental agents, normal cellular metabolism, or intrinsic weaknesses in the chemical bonds of DNA. Diverse…”
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Mitochondrial behavior during nuclear and mitochondrial DNA repair in Trypanosoma cruzi epimastigotes
Published in Experimental parasitology (01-12-2020)“…Different genotoxic agents can lead to DNA single- and double-strand breaks, base modification and oxidation. As most living organisms, Trypanosoma cruzi is…”
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Unveiling Benznidazole's mechanism of action through overexpression of DNA repair proteins in Trypanosoma cruzi
Published in Environmental and molecular mutagenesis (01-05-2014)“…Benznidazole (BZ) is the most commonly used drug for the treatment of Chagas disease. Although BZ is known to induce the formation of free radicals and…”
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Characterization of Trypanosoma cruzi MutY DNA glycosylase ortholog and its role in oxidative stress response
Published in Infection, genetics and evolution (01-11-2017)“…Trypanosoma cruzi is a protozoan parasite and the causative agent of Chagas disease. Like most living organisms, it is susceptible to oxidative stress, and…”
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Biochemical studies with DNA polymerase β and DNA polymerase β-PAK of Trypanosoma cruzi suggest the involvement of these proteins in mitochondrial DNA maintenance
Published in DNA repair (01-11-2008)“…Mammalian DNA polymerase β is a nuclear enzyme involved in the base excision and single-stranded DNA break repair pathways. In trypanosomatids, this protein…”
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Cloning and characterization of DNA polymerase η from Trypanosoma cruzi: Roles for translesion bypass of oxidative damage
Published in Environmental and molecular mutagenesis (01-06-2009)“…We report the cloning and characterization of the DNA polymerase η gene from Trypanosoma cruzi (TcPolη), the causative agent of Chagas disease. This protein,…”
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Cloning and characterization of DNA polymerase h from Trypanosoma cruzi: Roles for translesion bypass of oxidative damage
Published in Environmental and molecular mutagenesis (01-06-2009)“…We report the cloning and characterization of the DNA polymerase gene from Trypanosoma cruzi (TcPol), the causative agent of Chagas disease. This protein,…”
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